Abstract: The present disclosure relates to methods for treating celiac disease, especially refractory celiac disease, by administering a therapeutic amount of a JAK inhibitor, or a salt or prodrug thereof, with or instead of gluten-free diet, to a subject in need thereof. Additionally, methods are presented for preventing lymphoma in a subject having or suspected of having celiac disease.

Abstract: System and method of managing distribution of alert messages to a plurality of presentation devices. The system enables receiving an alert distribution request from an alerting source, including emergency situation data and indication of an area associated with the emergency situation, creating an alert message corresponding to the alert distribution request and identifying broadcasting operators, which enable distributing the alert message in the emergency area. Once the alert message is created and the broadcasting operators are identified, the system forwards the alert message to the identified broadcasting operators. The broadcasting operators broadcast the alert message to the plurality of presentation devices such as mobile devices, TV sets, radio devices, and the like.

Abstract: System and method of managing distribution of alert messages to a plurality of presentation devices. The system enables receiving an alert distribution request from an alerting source, including emergency situation data and indication of an area associated with the emergency situation, creating an alert message corresponding to the alert distribution request and identifying broadcasting operators, which enable distributing the alert message in the emergency area. Once the alert message is created and the broadcasting operators are identified, the system forwards the alert message to the identified broadcasting operators. The broadcasting operators broadcast the alert message to the plurality of presentation devices such as mobile devices, TV sets, radio devices, and the like.

Abstract: System and method of managing distribution of alert messages to a plurality of presentation devices. The method and system enable selecting a broadcast channel out of a plurality of broadcast channels according to a detected emergency situation. Each broadcast channel is designated for communication with a target group of presentation devices. An alert message, corresponding to the emergency situation is broadcasted to the target group over the selected broadcast channel, to allow each presentation device of the target group to present the broadcasted alert message.