Patents by Inventor Guyan Liang

Guyan Liang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for Determining the Stability of Organic Methyleneamines in the Presence of Semicarbazide-Sensitive Amine Oxidase
    Publication number: 20140363836
    Abstract: The present invention provides methods for determining the stability of methyleneamine, methyleneamine-like compounds or compounds containing an methyleneamine moiety in the presence of semicarbazide-sensitive amine oxidase (SSAO) or a biological sample containing SSAO activity. The disclosed methods may be configured in an assay format for high throughput screening applications.
    Type: Application
    Filed: May 12, 2014
    Publication date: December 11, 2014
    Inventors: Adedayo ADEDOYIN, Michael ANGELASTRO, Julie BICK, Jennifer CAIRNS, Yongqing HUANG, Guyan LIANG, Heng-Keang LIM
  • Method for determining the stability of organic methyleneamines in the presence of semicarbazide-sensitive amine oxidase
    Patent number: 8883410
    Abstract: The present invention provides methods for determining the stability of methyleneamine, methyleneamine-like compounds or compounds containing a methyleneamine moiety in the presence of semicarbazide-sensitive amine oxidase (SSAO) or a biological sample containing SSAO activity. The disclosed methods may be configured in an assay format for high throughput screening applications.
    Type: Grant
    Filed: November 18, 2012
    Date of Patent: November 11, 2014
    Assignee: Sanofi
    Inventors: Adedayo Adedoyin, Michael R. Angelastro, Julie Bick, Jennifer Caims, Yongqing Huang, Guyan Liang, Heng-Keang Lim
  • INDOLYL-PIPERIDINYL BENZYLAMINES AS BETA-TRYPTASE INHIBITORS
    Publication number: 20120245161
    Abstract: The present invention discloses and claims a series of substituted indolyl-piperidinyl benzylamines of the formula wherein R1, R2, R4 and R5 are as described herein. More specifically, the compounds of this invention are inhibitors of ?-tryptase and are, therefore, useful as pharmaceutical agents. Additionally, this invention also discloses methods of preparation of substituted indolyl-piperidinyl benzylamines.
    Type: Application
    Filed: June 5, 2012
    Publication date: September 27, 2012
    Applicant: SANOFI
    Inventors: Yong Mi CHOI-SLEDESKI, Guyan LIANG, Thaddeus R. NIEDUZAK, Gregory B. POLI, Patrick Wai-Kwok SHUM, Gregory T. STOKLOSA, Zhicheng ZHAO
  • TROPINONE BENZYLAMINES AS BETA-TRYPTASE INHIBITORS
    Publication number: 20120238600
    Abstract: The present invention discloses and claims a series of substituted tropinone benzylamines of formula (I): The compounds of this invention are inhibitors of ?-tryptase and are, therefore, useful as pharmaceutical agents. Additionally, this invention also discloses methods of preparation of substituted tropinone benzylamines.
    Type: Application
    Filed: June 5, 2012
    Publication date: September 20, 2012
    Applicant: SANOFI
    Inventors: Yong Mi CHOI-SLEDESKI, Guyan LIANG, Patrick Wai-Kwok SHUM
  • DISUBSTITUTED [4-(5-AMINOMETHYL-PHENYL)-PIPERIDIN-1-YL]- 1H-INDOL-3-YL]-METHANONES
    Publication number: 20120142735
    Abstract: The present invention extends to a compound of formula I: or a pharmaceutically acceptable salt of said compound, or a pharmaceutical composition comprising the compound of formula I and a pharmaceutically acceptable carrier. The invention is also directed to the use of a compound of formula I as an inhibitor of tryptase and for treating a patient suffering from, or subject to, a physiological condition in need of amelioration by an inhibitor of tryptase. The invention further includes methods for the preparation of a compound of formula I.
    Type: Application
    Filed: February 14, 2012
    Publication date: June 7, 2012
    Applicant: SANOFI
    Inventors: Yong- Mi CHOI-SLEDESKI, Charles J. GARDNER, Guyan LIANG, Gregory B. POLI, Patrick Wai-Kwok SHUM, Grzegory T. STOKLOSA, Zhicheng ZHAO
  • METHOD FOR DETERMINING THE STABILITY OF ORGANIC METHYLENEAMINES IN THE PRESENCE OF SEMICARBAZIDE-SENSITIVE AMINE OXIDASE
    Publication number: 20100028895
    Abstract: The present invention provides methods for determining the stability of methyleneamine, methyleneamine-like compounds or compounds containing an methyleneamine moiety in the presence of semicarbazide-sensitive amine oxidase (SSAO) or a biological sample containing SSAO activity. The disclosed methods may be configured in an assay format for high throughput screening applications.
    Type: Application
    Filed: January 8, 2008
    Publication date: February 4, 2010
    Inventors: Adedayo Adedoyin, Michael Angelastro, Julie Bick, Jennifer Cairns, Yongqing Huang, Guyan Liang, Heng-Keang Lim
  • Coumarins as iNOS inhibitors
    Patent number: 7538233
    Abstract: The present invention relates to coumarins of the formula (I): that are useful as inhibitors of nitric oxide synthase. Pharmaceutical compositions and methods of using these compounds as inhibitors of nitric oxide synthase are described herein.
    Type: Grant
    Filed: August 24, 2004
    Date of Patent: May 26, 2009
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: Sharon Jackson, Thaddeus Nieduzak, Sam Rebello, Guyan Liang, Yulin Chiang, Jean Merrill
  • Chemical compounds
    Patent number: 6977263
    Abstract: Provided herein are novel and useful compounds having a tryptase inhibition activity, pharmaceutical compositions comprising such compounds, and methods treating subjects suffering from a condition, disease, or disorder that can be ameliorated by the administration of an inhibitor of tryptase, e.g., asthma and inflammatory diseases, to name only a few.
    Type: Grant
    Filed: April 26, 2001
    Date of Patent: December 20, 2005
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: Peter C. Astles, Paul R. Eastwood, Olivier Houille, Julian Levell, Heinz Pauls, Mark Czekaj, Guyan Liang, Yong Gong, James Pribish, Kent Neuenschwander
  • Chemical compounds
    Publication number: 20050228018
    Abstract: Provided herein are novel and useful compounds having a tryptase inhibition activity, pharmaceutical compositions comprising such compounds, and methods treating subjects suffering from a condition, disease, or disorder that can be ameliorated by the administration of an inhibitor of tryptase, e.g., asthma and inflammatory diseases, to name only a few.
    Type: Application
    Filed: February 14, 2005
    Publication date: October 13, 2005
    Applicant: AVENTIS PHARMACEUTICALS INC.
    Inventors: Peter Astles, Paul Eastwood, Olivier Houille, Julian Levell, Heinz Pauls, Mark Czekaj, Guyan Liang, Yong Gong, James Pribish, Kent Neuenschwander
  • Coumarins as iNOS inhibitors
    Publication number: 20050054681
    Abstract: The present invention relates to coumarins of the formula (I): that are useful as inhibitors of nitric oxide synthase. Pharmaceutical compositions and methods of using these compounds as inhibitors of nitric oxide synthase are described herein.
    Type: Application
    Filed: August 24, 2004
    Publication date: March 10, 2005
    Applicant: Aventis Pharmaceuticals Inc.
    Inventors: Sharon Jackson, Thaddeus Nieduzak, Sam Rebello, Guyan Liang, Yulin Chiang, Jean Merrill
  • Chemical compounds
    Publication number: 20030187020
    Abstract: Provided herein are novel and useful compounds having a tryptase inhibition activity, pharmaceutical compositions comprising such compounds, and methods treating subjects suffering from a condition, disease, or disorder that can be ameliorated by the administration of an inhibitor of tryptase, e.g., asthma and inflammatory diseases, to name only a few.
    Type: Application
    Filed: April 26, 2001
    Publication date: October 2, 2003
    Inventors: Peter C. Astles, Paul R. Eastwood, Olivier Houille, Julian Levell, Heinz Pauls, Mark Czekaj, Guyan Liang, Yong Gong, James Pribish, Kent Neuenschwander