Patents by Inventor Guyla Simig

Guyla Simig has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of high purity perindopril and intermediates useful in the synthesis
    Patent number: 7326794
    Abstract: The invention relates to 1-{2(S)-[1(S)-(ethoxycarbonyl)butylamino]propionyl}-(3aS,7aS)octahydroindol-2(S)-carboxylic acid of the Formula I and the t-butylamine salt of the Formula I? thereof free of contaminations derivable from dicyclohexyl carbodiimide, and a process for the preparation thereof. The invention also relates to new intermediates of the general Formula III (wherein R stands for lower alkyl or aryl lower alkyl). The compound of the Formula I—perindopril—is a known ACE inhibitor.
    Type: Grant
    Filed: January 29, 2003
    Date of Patent: February 5, 2008
    Assignee: Les Laboratoires Servier
    Inventors: Guyla Simig, Tibor Mezei, Marta Porcs-Makkay, Attila Mandi
  • Process for the preparation of high purity perindopril
    Publication number: 20070197821
    Abstract: The invention relates to 1-{2(S)-[1(S)-(ethoxycarbonyl)butylamino]propionyl}-(3aS,7aS)octahydroindol-2(S)-carboxylic acid of the Formula I and the t-butylamine salt of the Formula I? thereof free of contaminations derivable from dicyclohexyl carbodiimide, and a process for the preparation thereof. The invention also relates to new intermediates of the general Formula III (wherein R stands for lower alkyl or aryl lower alkyl). The compound of the Formula I—perindopril—is a known ACE inhibitor.
    Type: Application
    Filed: April 20, 2007
    Publication date: August 23, 2007
    Applicant: LES LABORATOIRES SERVIER
    Inventors: Guyla Simig, Tibor Mezei, Marta Porcs-Makkay, Attila Mandi
  • Process for the preparation of high purity perindopril and intermediates useful in the synthesis
    Publication number: 20050119492
    Abstract: The invention relates to 1-{2(S)-[1(S)-(ethoxycarbonyl)butylamino]propionyl}-(3aS,7aS)octahydroindol-2(S)-carboxylic acid of the Formula I and the t-butylamine salt of the Formula I? thereof free of contaminations derivable from dicyclohexyl carbodiimide, and a process for the preparation thereof. The invention also relates to new intermediates of the general Formula III (wherein R stands for lower alkyl or aryl lower alkyl). The compound of the Formula I—perindopril—is a known ACE inhibitor.
    Type: Application
    Filed: January 29, 2003
    Publication date: June 2, 2005
    Inventors: Guyla Simig, Tibor Mezei, Marta Porcs-Makkay, Attila Mandi