Patents by Inventor Gwan-Sun Lee

Gwan-Sun Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PHARMACEUTICAL COMPOSITION CONTAINING CLOPIDOGREL CAMPHORSULFONATE OR POLYMORPHIC FORMS THEREOF
    Publication number: 20090209576
    Abstract: A pharmaceutical composition of the present invention which comprises clopidogrel camphorsulfonate of formula (I) or its polymorphic forms as an active ingredient is useful for treating or preventing a platelet aggregation-associated disease.
    Type: Application
    Filed: March 15, 2007
    Publication date: August 20, 2009
    Applicant: HANMI PHARM. CO., LTD.
    Inventors: Won Jeoung Kim, Han Kyong Kim, Kwee Hyun Suh, Gwan Sun Lee
  • Crystalline S-omeprazole strontium hydrate, method for preparing same, and pharmaceutical composition containing same
    Patent number: 7576219
    Abstract: This invention provides a crystalline S-omeprazole strontium hydrate for the prevention or treatment of gastric acid-related diseases, which has high optical purity, theremostability, solubility and nonhygroscopicity, a method for preparing same, and a pharmaceutical composition containing same.
    Type: Grant
    Filed: March 14, 2006
    Date of Patent: August 18, 2009
    Assignee: Hanmi Pharm. Co., Ltd
    Inventors: Tae Hee Ha, Hee Sook Oh, Won Jeoung Kim, Chang Hee Park, Eun Young Kim, Young Hoon Kim, Kwee Hyun Suh, Gwan Sun Lee
  • Expression vector for secreting antibody fragment using e. coli signal sequence and method for mass-producing antibody fragment
    Publication number: 20090104660
    Abstract: A recombinant expression vector capable of expressing and secreting an antibody fragment fused with E. coli thermostable enterotoxin signal sequence derivative or E.
    Type: Application
    Filed: October 14, 2004
    Publication date: April 23, 2009
    Inventors: Sung Youb Jung, Jin Sun Kim, Se Chang Kwon, Gwan Sun Lee
  • IMMUNOGLOBULIN FC FRAGMENT MODIFIED BY NON-PEPTIDE POLYMER AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
    Publication number: 20090053246
    Abstract: Disclosed are an Fc fragment modified by a non-peptide polymer, a pharmaceutical composition comprising the Fc fragment modified by the non-peptide polymer as a carrier, a complex of the Fc fragment and a drug via a linker and a pharmaceutical composition comprising such a complex. The Fc fragment modified by a non-peptide peptide according to the present invention lacks immunogenicity and effector functions. Due to these properties, the Fc fragment maintains the in vivo activity of a drug conjugated thereto in high levels, remarkably increases the serum half-life of the drug, and remarkably reduces the risk of inducing immune responses.
    Type: Application
    Filed: April 28, 2005
    Publication date: February 26, 2009
    Applicant: HANMI PHARMACEUTICAL CO., LTD.
    Inventors: Young Min Kim, Sung Min Bae, Dae Jin Kim, Dae Hae Song, Chang Ki Lim, Se Chang Kwon, Gwan Sun Lee
  • METHOD FOR PREPARING CLOPIDOGREL 1,5-NAPHTHALENEDISULFONATE OR HYDRATE THEREOF
    Publication number: 20090036683
    Abstract: The present invention relates to a method for preparing clopidogrel 1,5-naphthalenedisulfonate or a hydrate thereof, which comprises reacting a clopidogrel-acid addition salt with disodium 1,5-naphthalenedisulfonate or its hydrate in water, or a mixture of water and an organic solvent. High quality clopidogrel 1,5-naphthalenedisulfonate can be prepared by the inventive method by way of using non-corrosive disodium 1,5-naphthalenedisulfonate.
    Type: Application
    Filed: March 16, 2007
    Publication date: February 5, 2009
    Applicant: HANMI PHARM. CO., LTD.
    Inventors: Kwee Hyun Suh, Sang Min Yun, Eun Sook Kim, Gwan Sun Lee
  • Crystalline monohydrate clopidogrel naphthalenedisulfonate and process of preparation
    Patent number: 7470707
    Abstract: A crystalline clopidogrel naphthalenesulfonate or a hydrate thereof, a method for preparing same, and a pharmaceutical composition containing same are provided.
    Type: Grant
    Filed: October 25, 2004
    Date of Patent: December 30, 2008
    Assignee: Hanmi Pharm. Co., Ltd
    Inventors: Sangmin Yun, Eun Sook Kim, Hee Seock Kim, Bo Sung Kwon, Cheol Kyung Kim, Han Kyong Kim, Kwee-Hyun Suh, Gwan Sun Lee
  • Quinazoline Derivatives as a Multiplex Inhibitor and Method For the Preparation Thereof
    Publication number: 20080318950
    Abstract: The present invention relates to a novel quinazoline derivative and a pharmaceutically acceptable salt thereof as a multiplex inhibitor, a method for the preparation thereof, and a pharmaceutical composition and a therapeutic composition comprising same as an active ingredient. The inventive quinazoline derivative as a multiplex inhibitor can selectively and effectively inhibit diseases caused by the overactivity of a tyrosine kinase.
    Type: Application
    Filed: November 8, 2006
    Publication date: December 25, 2008
    Applicant: HANMI PHARM. CO., LTD
    Inventors: Young-Gil Ahn, Jong Woo Kim, Keuk Chan Bang, Bum Woo Park, Se Young Kim, Kyungik Lee, Kyuhang Lee, Myoung-Sil Ko, Han Kyong Kim, Young Hoon Kim, Maeng Sup Kim, Gwan Sun Lee
  • Method For the Mass Production of Immunoglobulin Fc Region Deleted Initial Methionine Residues
    Publication number: 20080293106
    Abstract: Disclosed is a method for the mass production of a monomeric or dimeric immunoglobulin Fc region, free of initial methionine residues, using a recombinant expression vector comprising a nucleotide sequence coding for a recombinant immunoglobulin Fc region comprising an immunoglobulin Fc region linked at the N-terminus thereof to an immunoglobulin Fc region via a peptide bond.
    Type: Application
    Filed: August 16, 2006
    Publication date: November 27, 2008
    Inventors: Sung youb Jung, Jin Sun Kim, Jin hwan Shin, Se-Chang Kwon, Gwan-Sun Lee, Dae hae Song
  • Method of preparing thieno[3,2-c]pyridine derivatives and intermediates used therein
    Patent number: 7449580
    Abstract: Ticlopidine and clopidogrel having high blood platelet aggregation inhibitory and anti-thrombotic activities are simply prepared by reacting a substituted thiophene derivative with a 2-chlorobenzylamine derivative.
    Type: Grant
    Filed: March 3, 2005
    Date of Patent: November 11, 2008
    Assignee: Hanmi Pharm. Co., Ltd
    Inventors: Sangmin Yun, Eun Sook Kim, Hee Seock Kim, Tae Hee Ha, Kwee-Hyun Suh, Gwan Sun Lee
  • INSULINOTROPIC PEPTIDE CONJUGATE USING CARRIER SUBSTANCE
    Publication number: 20080124347
    Abstract: The present invention relates to an insulinotropic peptide conjugate having improved in-vivo duration of efficacy and stability, comprising an insulinotropic peptide, a non-peptide polymer and a carrier substance, which are covalently linked to each other, and a use of the same. The insulinotropic peptide conjugate of the present invention has the in-vivo activity which is maintained relatively high, and has remarkably increased blood half-life, and thus it can be desirably employed in the development of long acting formulations of various peptide drugs.
    Type: Application
    Filed: May 10, 2007
    Publication date: May 29, 2008
    Applicant: HANMI PHARM. IND. CO., LTD.
    Inventors: Young Min Kim, Dae Jin Kim, Sung Min Bae, Chang Ki Lim, Se Chang Kwon, Gwan Sun Lee, Dae Hae Song, Young Hoon Kim
  • Clathrate of Azithromycin Hydrate With 1,2-Propyleneglycol, Method For The Manufacture Thereof, And Pharmaceutical Composition containing same
    Publication number: 20080076725
    Abstract: The present invention relates to a clathrate of azithromycin hydrate with 1,2-propyleneglycol of formula (I), a method for the manufacture thereof, and a pharmaceutical composition containing same. The inventive compound is much less hygroscopic than azithromycin hydrate or crystals known in the art, therefore, it can be useful for the preparation of a medicine for treating various microbial infections. wherein m ranges from 1 to 2 and n, from 0.30 to 0.45.
    Type: Application
    Filed: March 2, 2007
    Publication date: March 27, 2008
    Inventors: Kwee-Hyun SUH, Gi-Jeong Kim, Sang-Min Yoon, Mi-Ra Seong, Gwan-Sun Lee
  • Modified human granulocyte-colony stimulating factor and process for producing same
    Publication number: 20080064066
    Abstract: A modified human granulocyte-colony stimulating factor (hG-CSF) is produced by culturing a microorganism transformed with an expression vector comprising a gene encoding a modified hG-CSF to produce and secrete the modified hG-CSF to periplasm, said modified hG-CSF being obtained by replacing at least one of the 1st, 2nd, 3rd and 17th amino acids of wild-type hG-CSF (SEQ ID NO: 2) with other amino acid
    Type: Application
    Filed: October 19, 2007
    Publication date: March 13, 2008
    Applicant: Hanmi Pharm. Co., Ltd.
    Inventors: Se-Chang Kwon, Sung-Youb Jung, Sung-Min Bae, Gwan-Sun Lee
  • Method for the Preparation of D-Erythro-2,2-Difluoro-2-Deoxy-1-Oxoribose Derivative
    Publication number: 20080058509
    Abstract: 3R-carboxylate enantiomer derivative of formula (III) can be prepared easily and selectively by the method of the present invention, and a highly pure D-erythro-2,2-difluoro-2-deoxy-1-oxoribose derivative can be prepared efficiently from the compound of formula (III) as an intermediate.
    Type: Application
    Filed: June 23, 2005
    Publication date: March 6, 2008
    Applicant: HANMI PHARM, CO., LTD.
    Inventors: Jaeheon Lee, Gha-Seung Park, Moonsub Lee, Cheol-Kyong Kim, Jae-Chul Lee, Young-Kil Chang, Gwan-Sun Lee
  • Quinazoline Derivatives For Inhibiting Cancer Cell Growth And Method For The Preparation Thereof
    Publication number: 20080009509
    Abstract: The present invention relates to a novel quinazoline derivative and a pharmaceutically acceptable salt thereof for inhibiting the growth of cancer cells, a method for the preparation thereof and a pharmaceutical composition comprising same as an active ingredient.
    Type: Application
    Filed: December 20, 2005
    Publication date: January 10, 2008
    Applicant: HANMI PHARM CO., LTD
    Inventors: Young Jin Ham, Ji Hyeon Gong, Mi Yong Cha, Jong Woo Kim, Maeng Sup Kim, Eun Young Kim, Ji Yeon Song, Chang In Kim, Se Young Kim, Gwan Sun Lee
  • Clathrate of azithromycin hydrate with 1,2-propyleneglycol, method for the manufacture thereof and pharmaceutical composition comprising same
    Patent number: 7205394
    Abstract: A clathrate of azithromycin hydrate with 1,2-propyleneglycol is much less hygroscopic than azithromycin hydrate or crystals known in the art, therefore, it can be useful for the preparation of a medicine for treating various microbial infections.
    Type: Grant
    Filed: April 25, 2002
    Date of Patent: April 17, 2007
    Assignee: Hanmi Pharm. Co., Ltd.
    Inventors: Kwee-Hyun Suh, Gi-Jeong Kim, Sang-Min Yoon, Mi-Ra Seong, Gwan-Sun Lee
  • Method for preparing risperidone
    Patent number: 7202360
    Abstract: Risperidone is prepared in a high yield by reacting 2,4-difluorophenyl(4-piperidinyl)methanone oxime hydrochloride and 3-(2-chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one in an aqueous alkali hydroxide solution having an alkali hydroxide concentration in the range of 20 to 40%.
    Type: Grant
    Filed: October 17, 2003
    Date of Patent: April 10, 2007
    Assignee: Hanmi Pharm Co., Ltd.
    Inventors: Nam-Du Kim, Jae-Heon Lee, Moon-Sub Lee, Young-Kil Chang, Gwan-Sun Lee
  • Crystalline acid salts of cefdinir and process for preparing cefdinir using same
    Patent number: 7157576
    Abstract: High purity cefdinir is prepared in a high yield by a process comprising the steps of: treating a crystalline salt of a cefdinir intermediate with a formic acid-sulfuric acid mixture or a formic acid-methanesulfonic acid mixture to obtain a crystalline salt of cefdinir and reacting the crystalline salt with a base in a solvent.
    Type: Grant
    Filed: June 5, 2002
    Date of Patent: January 2, 2007
    Assignee: Hanmi Pharm. Co., Ltd.
    Inventors: Gwan-Sun Lee, Young-Kil Chang, Hong-Sun Kim, Chul-Hyun Park, Gha-Seung Park, Cheol-Kyung Kim
  • Process for the selective preparation of 3-(z) propenyl-cephem compound
    Patent number: 7112672
    Abstract: A 3-(Z)-propenyl cephem compound is selectively prepared by reacting a phosphoranylidene cephem compound with acetaldehyde in the presence of a base in a solvent mixture comprising diethyl ether, formula (I), wherein R is a carboxyl protecting group; R1 is hydrogen or R2CH2CO—; and R2 is ethyl, 2-thiophenyl, phenyl, p-hydroxyphenyl or phenoxy
    Type: Grant
    Filed: April 17, 2002
    Date of Patent: September 26, 2006
    Assignee: Hanmi Pharm. Co., Ltd.
    Inventors: Gwan-Sun Lee, Young-Kil Chang, Hong-Sun Kim, Jae-Heon Lee, Chul-Hyun Park, Gha-Seung Park, Cheol-Kyung Kim
  • Method for the selective preparation of 3-oxo-4-aza-5?-androstane compound
    Patent number: 7084274
    Abstract: This invention relates to a method for selectively preparing the 3-oxo-4-aza-5¥á-androstane compound which is used as an intermediate of finasteride by heating 3-oxo-4-aza-5-androstene in a mixture of formic acid and an alkanediol in the presence of zinc.
    Type: Grant
    Filed: August 13, 2003
    Date of Patent: August 1, 2006
    Assignee: Hanmi Pharm. Co., Ltd.
    Inventors: Young-Ho Moon, Kyung-Ik Lee, Gha-Seung Park, Chul-Hyun Park, Jae-Cheol Lee, Gwan-Sun Lee, Young-Kil Chang
  • Expression and secretion vector for human interferon alpha and process for producing human interferon alpha by employing same
    Patent number: 7052867
    Abstract: Disclosed in this invention are an expression vector for the secretive production of human interferon alpha (hIFN?) comprising a polynucleotide encoding a modified E. coli thermostable enterotoxin II signal sequence and a polynucleotide encoding hIFN? ligated to the 3?-end thereof; a microorganism transformed with the expression vector; and a process for secretively producing human interferon by culturing the microorganism, the process being capable of secreting a soluble form of active hIFN?, which does not contain an additional methionine residue at its N-terminal, into the periplasm of an E. coli cell.
    Type: Grant
    Filed: January 19, 2001
    Date of Patent: May 30, 2006
    Assignee: Hanmi Pharm. Co., Ltd.
    Inventors: Se-Chang Kwon, Sung-Youb Jung, Ki-Doo Choi, Cha-Soon Kim, Sung-Min Bae, Gwan-Sun Lee