Patents by Inventor Gwen Liu

Gwen Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pre-miRNA loop-modulated target regulation
    Publication number: 20090004668
    Abstract: By employing essential nucleotides from both the stem and loop of precursor-miRNA, greater specificity is achieved as to the mRNAs that are repressed. It is found that besides the seed sequence of the stem of the pre-miRNA, nucleotides in the loop affect the activity and specificity of the cursor- and the processing and binding to target mRNA. By using both sequences in the natural pre-miRNA or modified mimetics, one can screen for cellular miRNA expression, modulate cell properties with greater specificity and investigate cellular activity as to phenotype and response to external stimuli in the presence and absence of target protein expression.
    Type: Application
    Filed: June 20, 2008
    Publication date: January 1, 2009
    Inventors: Chang-Zheng Chen, Hyeyoung Min, Gwen Liu
  • Identification of sortase gene
    Patent number: 7238489
    Abstract: The present invention is a substantially purified sortase-transamidase enzyme from Gram-positive bacteria, such as Staphylococcus aureus.
    Type: Grant
    Filed: October 18, 2004
    Date of Patent: July 3, 2007
    Assignee: The Regents of the University of California
    Inventors: Olaf Schneewind, Sarkis Mazmanian, Gwen Liu, Hung Ton-That
  • Identification of sortase gene
    Patent number: 7101692
    Abstract: The present invention is a substantially purified sortase-transamidase enzyme from Gram-positive bacteria, such as Staphylococcus aureus. A specific sortase-transamidase enzyme disclosed has a molecular weight of about 29,076 daltons and catalyzes a reaction that covalently cross-links the carboxyl terminus of a protein having a sorting signal to the peptidoglycan of a Gram-positive bacterium, where the sorting signal has a a motif of NPQ/KTN/G therein. Variants of the enzyme, methods for cloning the gene encoding the enzyme and expressing the cloned gene, and methods of use of the enzyme, including for screening for antibiotics and for display of proteins or peptides on the surfaces of Gram-positive bacteria, are also disclosed.
    Type: Grant
    Filed: August 14, 2002
    Date of Patent: September 5, 2006
    Assignee: The Regents of the University of California
    Inventors: Olaf Schneewind, Sarkis K. Mazmanian, Gwen Liu, Hong Ton-That
  • Identification of sortase gene
    Publication number: 20050069984
    Abstract: The present invention is a substantially purified sortase-transamidase enzyme from Gram-positive bacteria, such as Staphylococcus aureus.
    Type: Application
    Filed: October 18, 2004
    Publication date: March 31, 2005
    Inventors: Olaf Schneewind, Sarkis Mazmanian, Gwen Liu, Hung Ton-That
  • Identification of sortase gene
    Patent number: 6773706
    Abstract: The present invention is a substantially purified sortase-transamidase enzyme from Gram-positive bacteria, such as Staphylococcus aureus.
    Type: Grant
    Filed: August 21, 2001
    Date of Patent: August 10, 2004
    Assignee: The Regents of the University of California
    Inventors: Olaf Schneewind, Sarkis Mazmanian, Gwen Liu, Hung Ton-That
  • Identification of sortase gene
    Publication number: 20030153020
    Abstract: The present invention is a substantially purified sortase-transamidase enzyme from Gram-positive bacteria, such as Staphylococcus aureus. A specific sortase-transamidase enzyme disclosed has a molecular weight of about 29,076 daltons and catalyzes a reaction that covalently cross-links the carboxyl terminus of a protein having a sorting signal to the peptidoglycan of a Gram-positive bacterium, where the sorting signal has a a motif of NPQ/KTN/G therein. Variants of the enzyme, methods for cloning the gene encoding the enzyme and expressing the cloned gene, and methods of use of the enzyme, including for screening for antibiotics and for display of proteins or peptides on the surfaces of Gram-positive bacteria, are also disclosed.
    Type: Application
    Filed: August 14, 2002
    Publication date: August 14, 2003
    Inventors: Olaf Schneewind, Sarkis K. Mazmanian, Gwen Liu, Hong Ton-That
  • Identification of sortase gene
    Publication number: 20030022178
    Abstract: The present invention is a substantially purified sortase-transamidase enzyme from Gram-positive bacteria, such as Staphylococcus aureus.
    Type: Application
    Filed: August 21, 2001
    Publication date: January 30, 2003
    Inventors: Olaf Schneewind, Sarkis Mazmanian, Gwen Liu, Hung Ton-That