Patents by Inventor Gwenaelle Bestel-Corre

Gwenaelle Bestel-Corre has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10858679
    Abstract: Process for the production of methionine or its derivatives by culturing a microorganism in an appropriate culture medium comprising a source of carbon and a source of sulfur. The microorganism and/or the culture medium are modified in such way that the methionine/carbon source yield is increased. The isolation of methionine or its derivates from the fermentation medium is also described.
    Type: Grant
    Filed: February 12, 2016
    Date of Patent: December 8, 2020
    Assignee: EVONIK DEGUSSA GMBH
    Inventors: Rainer Figge, Philippe Soucaille, Guillaume Barbier, Gwénaëlle Bestel-Corre, Cédric Boisart, Michel Chateau
  • Patent number: 10858675
    Abstract: The present invention relates to a recombinant microorganism capable of producing 2,4-dihydroxybutyrate, which is characterized by an increased cellular export, and preferably by a decreased cellular import, of said 2,4 DHB. The invention also relates to a method for the optimized production of 2,4-dihydroxybutyrate by culturing said microorganism in a fermentation medium and recovering 2,4-DHB from said medium.
    Type: Grant
    Filed: April 7, 2016
    Date of Patent: December 8, 2020
    Assignee: METABOLIC EXPLORER
    Inventors: Wanda Dischert, Laurence Dumon-Seignovert, Perrine Vasseur, Gwénaëlle Bestel-Corre, Philippe Soucaille
  • Patent number: 10689671
    Abstract: The present invention relates to a recombinant microorganism useful for the production of 1,2-propanediol and process for the preparation of 1,2-propanediol. The microorganism of the invention is modified in a way that the 1,2-propanediol production is improved by enhancing NADPH dependent HAR activity.
    Type: Grant
    Filed: May 12, 2015
    Date of Patent: June 23, 2020
    Assignee: METABOLIC EXPLORER
    Inventors: Pascale Aliprandi, Emilie Navarro, Céline Raynaud, Gwénaëlle Bestel Corre, Philippe Soucaille
  • Patent number: 10415062
    Abstract: The present invention relates to a genetically modified microorganism for the production of 2,4-dihydroxybutyrate, by metabolic transformation of xylose via the 1,2,4-butanetriol intermediate. The invention also relates to a method for the production of 2,4-dihydroxybutyrate by culturing said genetically modified microorganism in a fermentation medium and recovering 2,4-DHB from said medium.
    Type: Grant
    Filed: April 7, 2015
    Date of Patent: September 17, 2019
    Assignee: METABOLIC EXPLORER
    Inventors: Philippe Soucaille, Gwénaëlle Bestel-Corre, Laurence Dumon-Seignovert
  • Publication number: 20190276859
    Abstract: The present invention relates to a new method for the production of methionine or its hydroxy analog form by conversion of a source of carbon in a fermentative process comprising culturing a microorganism genetically modified for the production of methionine orits hydroxy analog form, wherein said microorganism comprises functional genes coding PTS carbohydrate utilization system and wherein the expression of proteins regulated the expression of phosphoenolpyruvate synthase (PPS) is down-regulated. The present invention also relates to the genetically modified microorganism used in the method of the invention.
    Type: Application
    Filed: July 6, 2017
    Publication date: September 12, 2019
    Applicant: Evonik Degussa GmbH
    Inventors: Gwenaëlle BESTEL-CORRE, Céline RAYNAUD
  • Publication number: 20180105845
    Abstract: The present invention relates to a recombinant microorganism capable of producing 2,4-dihydroxybutyrate, which is characterized by an increased cellular export, and preferably by a decreased cellular import, of said 2,4 DHB. The invention also relates to a method for the optimized productionof 2,4-dihydroxybutyrate by culturing said microorganism in a fermentation medium and recovering 2,4-DHB from said medium.
    Type: Application
    Filed: April 7, 2016
    Publication date: April 19, 2018
    Applicant: METABOLIC EXPLORER
    Inventors: Wanda DISCHERT, Laurence DUMON-SEIGNOVERT, Perrine VASSEUR, Gwénaëlle BESTEL-CORRE, Philippe SOUCAILLE
  • Publication number: 20180100169
    Abstract: The present invention relates to a genetically modified microorganism for the production of 2,4-dihydroxybutyrate, by metabolic transformation of xylose via the 1,2,4-butanetriol intermediate. The invention also relates to a method for the production of 2,4-dihydroxybutyrate by culturing said genetically modified microorganism in a fermentation medium and recovering 2,4-DHB from said medium.
    Type: Application
    Filed: April 7, 2015
    Publication date: April 12, 2018
    Applicant: METABOLIC EXPLORER
    Inventors: Philippe SOUCAILLE, Gwénaëlle BESTEL-CORRE, Laurence DUMON-SEIGNOVERT
  • Publication number: 20170145446
    Abstract: The present invention relates to a recombinant microorganism useful for the production of 1,2-propanediol and process for the preparation of 1,2-propanediol. The microorganism of the invention is modified in a way that the 1,2-propanediol production is improved by enhancing NADPH dependent HAR activity.
    Type: Application
    Filed: May 12, 2015
    Publication date: May 25, 2017
    Applicant: METABOLIC EXPLORER
    Inventors: Pascale ALIPRANDI, Emilie NAVARRO, Céline RAYNAUD, Gwénaëlle BESTEL CORRE, Philippe SOUCAILLE
  • Patent number: 9382561
    Abstract: The present invention relates to a method for the production of methionine using modified strains with attenuated transformation of threonine. This can be achieved by reducing threonine transformation into glycine, and/or by reducing its transformation to ?-ketobutyrate. The invention also concerns the modified strains with attenuated transformation of threonine.
    Type: Grant
    Filed: December 29, 2010
    Date of Patent: July 5, 2016
    Assignee: METABOLIC EXPLORER
    Inventors: Cedric Boisart, Gwenaelle Bestel-Corre, Guillaume Barbier, Rainer Figge
  • Publication number: 20160160249
    Abstract: Process for the production of methionine or its derivatives by culturing a microorganism in an appropriate culture medium comprising a source of carbon and a source of sulfur. The microorganism and/or the culture medium are modified in such way that the methionine/carbon source yield is increased. The isolation of methionine or its derivates from the fermentation medium is also described.
    Type: Application
    Filed: February 12, 2016
    Publication date: June 9, 2016
    Applicant: METABOLIC EXPLORER
    Inventors: Rainer FIGGE, Philippe SOUCAILLE, Guillaume BARBIER, Gwénaëlle BESTEL-CORRE, Cédric BOISART, Michel CHATEAU
  • Patent number: 8795990
    Abstract: The present invention relates to the use of recombinant homoserine transsuccinylase enzymes with altered feedback sensitivity (MetA*) and possibly recombinant S-adenosyl methionine synthetase enzymes with reduced activity (MetK*) for the production of methionine, its precursors or derivatives thereof.
    Type: Grant
    Filed: May 12, 2005
    Date of Patent: August 5, 2014
    Assignee: Metabolic Explorer
    Inventors: Gwénaëlle Bestel-Corre, Michel Chateau, Rainer Figge, Céline Raynaud, Philippe Soucaille
  • Patent number: 8748136
    Abstract: The present invention relates to a method for the production of methionine or its derivatives by culturing a microorganism in an appropriate culture medium comprising a source of carbon and a source of sulphur. The microorganism and/or the culture medium and/or the process parameters were modified in a way that the accumulation of the by-product N-acyl-methionine (NAM) is reduced. The isolation of methionine or its derivatives from the fermentation medium is also claimed.
    Type: Grant
    Filed: February 12, 2009
    Date of Patent: June 10, 2014
    Assignee: Metabolic Explorer
    Inventors: Rainer Figge, Philippe Soucaille, Gwénaëlle Bestel-Corre
  • Publication number: 20130210097
    Abstract: The present invention is related to a method for the fermentative production of glycolic acid, its derivatives or precursors, comprising the culture of an Escherichia coli strain in an appropriate culture medium comprising a carbon source, and the recovery of glycolic acid in the medium, wherein said E. coli strain is modified to improve the conversion of orotate into orotidine 5?-P. The invention is also related to the modified E. coli strain, showing an improved conversion of orotate into orotidine 5?-P, and optionally that was furthermore modified for an improved glycolic acid production.
    Type: Application
    Filed: August 27, 2010
    Publication date: August 15, 2013
    Applicant: METABOLIC EXPLORER
    Inventors: Wanda Dischert, Cedric Colomb, Gwenaelle Bestel-Corre
  • Publication number: 20120288904
    Abstract: The present invention relates to a method for the production of methionine using modified strains with attenuated transformation of threonine. This can be achieved by reducing threonine transformation into glycine, and/or by reducing its transformation to ?-ketobutyrate. The invention also concerns the modified strains with attenuated transformation of threonine.
    Type: Application
    Filed: December 29, 2010
    Publication date: November 15, 2012
    Applicant: METABOLIC EXPLORER
    Inventors: Cedric Boisart, Gwenaelle Bestel-Corre, Guillaume Barbier, Rainer Figge
  • Patent number: 8143031
    Abstract: The present invention claims an isolated polypeptide having L-amino-acid-N-acyl transferase enzymatic activity and a modified microorganism in which this enzyme is overexpressed. Substrates of said enzyme include mainly methionine and their derivatives or analogs. Overexpression in sulphur-containing amino acid producing microorganisms permits the production of large amounts of N-acylated sulphur-containing amino acids. The isolation of the N-acylated sulphur-containing amino acids from the fermentation medium is also claimed.
    Type: Grant
    Filed: February 12, 2009
    Date of Patent: March 27, 2012
    Assignee: Metabolic Explorer
    Inventors: Rainer Figge, Guillaume Barbier, Gwénaëlle Bestel-Corre
  • Patent number: 8088620
    Abstract: The invention relates to optimised micro-organism strains for the biotransformation production of molecules having NADPH-consuming biosynthetic pathways. The inventive strains can be used in NADPH-consuming biotransformation methods. Said strains are characterized in that one or more NADPH-oxidizing activities are limited.
    Type: Grant
    Filed: November 5, 2004
    Date of Patent: January 3, 2012
    Assignee: Metabolic Explorer
    Inventors: Gwénaëlle Bestel-Corre, Cédric Boisart, Michel Chateau, Benjamin Gonzalez, Philippe Soucaille, Rainer Figge, Olivier Zink
  • Publication number: 20100047879
    Abstract: The present invention relates to a method for the production of methionine or its derivatives by culturing a microorganism in an appropriate culture medium comprising a source of carbon and a source of sulphur. The microorganism and/or the culture medium and/or the process parameters were modified in a way that the accumulation of the by-product N-acyl-methionine (NAM) is reduced. The isolation of methionine or its derivatives from the fermentation medium is also claimed.
    Type: Application
    Filed: February 12, 2009
    Publication date: February 25, 2010
    Inventors: Rainer Figge, Philippe Soucaille, Gwenaelle Bestel-Corre
  • Publication number: 20100047880
    Abstract: The present invention claims an isolated polypeptide having L-amino-acid-N-acyl transferase enzymatic activity and a modified microorganism in which this enzyme is overexpressed. Substrates of said enzyme include mainly methionine and their derivatives or analogs. Overexpression in sulphur-containing amino acid producing microorganisms permits the production of large amounts of N-acylated sulphur-containing amino acids. The isolation of the N-acylated sulphur-containing amino acids from the fermentation medium is also claimed.
    Type: Application
    Filed: February 12, 2009
    Publication date: February 25, 2010
    Inventors: RAINER FIGGE, GUILLAUME BARBIER, GWENAELLE BESTEL-CORRE
  • Publication number: 20090029424
    Abstract: The present invention relates to the use of recombinant homoserine transsuccinylase enzymes with altered feedback sensitivity (MetA*) and possibly recombinant S-adenosyl methionine synthetase enzymes with reduced activity (MetK*) for the production of methionine, its precursors or derivatives thereof.
    Type: Application
    Filed: May 12, 2005
    Publication date: January 29, 2009
    Applicant: Metabolic Explorer
    Inventors: Gwenaelle Bestel-Corre, Michel Chateau, Rainer Figge, Celine Raynaud, Philippe Soucaille
  • Publication number: 20080286840
    Abstract: A microorganism in which enzymes are expressed that have one or several of the following activities cystathionine-?-synthases and/or phosphohomoserine sulfhydrylase and/or acylhomoserine sulfhydrylases and that have at the same time low ?-elimination activity is disclosed and also relates to recombinant enzymes that have one or several of the following activities cystathionine-?-synthase and/or phosphohomoserine and/or acylhomoserine sulfhydrylase, have at the same time low ?-eliminase activity and are used for the fermentative production of amino acids, in particular, methionine.
    Type: Application
    Filed: February 7, 2006
    Publication date: November 20, 2008
    Inventors: Rainer Figge, Gwenaelle Bestel-Corre, Philippe Soucaille