Patents by Inventor Gwo-Hwa Lee

Gwo-Hwa Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • , the receptor for leptin, nucleic acids encoding the receptor, and uses thereof
    Patent number: 7812137
    Abstract: The present invention relates to identification of a receptor for a satiety factor, which is involved in body weight homeostasis. Mutations in this receptor are associated with obese phenotypes. In particular, the present invention relates to identification and characterization of the receptor for leptin, including a naturally occurring soluble form of the receptor that is expected to modulate leptin activity, in particular to agonize leptin activity. The invention further relates to the nucleic acids encoding the receptor, and to methods for using the receptor, e.g., to identify leptin analogs, therapeutically, such as in gene therapy or in soluble form as an agonist or antagonist of leptin activity, or diagnostically.
    Type: Grant
    Filed: October 24, 2006
    Date of Patent: October 12, 2010
    Assignee: The Rockefeller University
    Inventors: Jeffrey M. Friedman, Gwo-Hwa Lee, Ricardo Proenca, Ella Ioffe
  • Db, the receptor for leptin, nucleic acids encoding the receptor, and uses thereof
    Patent number: 7619079
    Abstract: The present invention relates to identification of a receptor for a satiety factor, which is involved in body weight homeostasis. Mutations in this receptor are associated with obese phenotypes. In particular, the present invention relates to identification and characterization of the receptor for leptin, including a naturally occurring soluble form of the receptor that is expected to modulate leptin activity, in particular to agonize leptin activity. The invention further relates to the nucleic acids encoding the receptor, and to methods for using the receptor, e.g., to identify leptin analogs, therapeutically, such as in gene therapy or in soluble form as an agonist or antagonist of leptin activity, or diagnostically.
    Type: Grant
    Filed: April 24, 2006
    Date of Patent: November 17, 2009
    Assignee: The Rockefeller University
    Inventors: Jeffrey M. Friedman, Gwo-Hwa Lee, Ricardo Proenca
  • DB, the receptor for leptin, nucleic acids encoding the receptor, and uses thereof
    Patent number: 7612171
    Abstract: The present invention relates to identification of a receptor for a satiety factor, which is involved in body weight homeostasis. Mutations in this receptor are associated with obese phenotypes. In particular, the present invention relates to identification and characterization of the receptor for leptin, including a naturally occurring soluble form of the receptor that is expected to modulate leptin activity, in particular to agonize leptin activity. The invention further relates to the nucleic acids encoding the receptor, and to methods for using the receptor, e.g., to identify leptin analogs, therapeutically, such as in gene therapy or in soluble form as an agonist or antagonist of leptin activity, or diagnostically.
    Type: Grant
    Filed: March 16, 2006
    Date of Patent: November 3, 2009
    Assignee: The Rockefeller University
    Inventors: Jeffrey M. Friedman, Gwo-Hwa Lee, Ricardo Proenca
  • Db, the receptor for leptin, nucleic acids encoding the receptor, and uses thereof
    Publication number: 20070048836
    Abstract: The present invention relates to identification of a receptor for a satiety factor, which is involved in body weight homeostasis. Mutations in this receptor are associated with obese phenotypes. In particular, the present invention relates to identification and characterization of the receptor for leptin, including a naturally occurring soluble form of the receptor that is expected to modulate leptin activity, in particular to agonize leptin activity. The invention further relates to the nucleic acids encoding the receptor, and to methods for using the receptor, e.g., to identify leptin analogs, therapeutically, such as in gene therapy or in soluble form as an agonist or antagonist of leptin activity, or diagnostically.
    Type: Application
    Filed: October 24, 2006
    Publication date: March 1, 2007
    Inventors: Jeffrey Friedman, Gwo-Hwa Lee, Ricardo Proenca, Ella Ioffe
  • Db, the receptor for leptin, nucleic acids encoding the receptor, and uses thereof
    Publication number: 20070020686
    Abstract: The present invention relates to identification of a receptor for a satiety factor, which is involved in body weight homeostasis. Mutations in this receptor are associated with obese phenotypes. In particular, the present invention relates to identification and characterization of the receptor for leptin, including a naturally occurring soluble form of the receptor that is expected to modulate leptin activity, in particular to agonize leptin activity. The invention further relates to the nucleic acids encoding the receptor, and to methods for using the receptor, e.g., to identify leptin analogs, therapeutically, such as in gene therapy or in soluble form as an agonist or antagonist of leptin activity, or diagnostically.
    Type: Application
    Filed: April 24, 2006
    Publication date: January 25, 2007
    Inventors: Jeffrey Friedman, Gwo-Hwa Lee, Ricardo Proenca
  • Oligonucleotides of the OB-R isoforms and methods of diagnosing body weight
    Patent number: 7148004
    Abstract: The present invention relates to identification of a receptor for a satiety factor, which is involved in body weight homeostasis. Mutations in this receptor are associated with obese phenotypes. In particular, the present invention relates to identification and characterization of the receptor for leptin, including a naturally occurring soluble form of the receptor that is expected to modulate leptin activity, in particular to agonize leptin activity. The invention further relates to the nucleic acids encoding the receptor, and to methods for using the receptor, e.g., to identify leptin analogs, therapeutically, such as in gene therapy or in soluble form as an agonist or antagonist of leptin activity, or diagnostically.
    Type: Grant
    Filed: January 16, 1997
    Date of Patent: December 12, 2006
    Assignee: The Rockefeller University
    Inventors: Jeffrey M. Friedman, Gwo-Hwa Lee, Ricardo Proenca, Ella Ioffe
  • DB, the receptor for leptin, nucleic acids encoding the receptor, and uses thereof
    Publication number: 20060228757
    Abstract: The present invention relates to identification of a receptor for a satiety factor, which is involved in body weight homeostasis. Mutations in this receptor are associated with obese phenotypes. In particular, the present invention relates to identification and characterization of the receptor for leptin, including a naturally occurring soluble form of the receptor that is expected to modulate leptin activity, in particular to agonize leptin activity. The invention further relates to the nucleic acids encoding the receptor, and to methods for using the receptor, e.g., to identify leptin analogs, therapeutically, such as in gene therapy or in soluble form as an agonist or antagonist of leptin activity, or diagnostically.
    Type: Application
    Filed: March 16, 2006
    Publication date: October 12, 2006
    Inventors: Jeffrey Friedman, Gwo-Hwa Lee, Ricardo Proenca
  • DB, the receptor for leptin
    Patent number: 7084252
    Abstract: The present invention relates to identification of a receptor for a satiety factor, which is involved in body weight homeostasis. Mutations in this receptor are associated with obese phenotypes. In particular, the present invention relates to identification and characterization of the receptor for leptin, including a naturally occurring soluble form of the receptor that is expected to modulate leptin activity, in particular to agonize leptin activity. The invention further relates to the nucleic acids encoding the receptor, and to methods for using the receptor, e.g., to identify leptin analogs, therapeutically, such as in gene therapy or in soluble form as an agonist or antagonist of leptin activity, or diagnostically.
    Type: Grant
    Filed: January 16, 1996
    Date of Patent: August 1, 2006
    Assignee: The Rockefeller University
    Inventors: Jeffrey M. Friedman, Gwo-Hwa Lee, Ricardo Proenca
  • Nucleic acids db, the receptor for leptin
    Patent number: 7063958
    Abstract: The present invention relates to identification of a receptor for a satiety factor, which is involved in body weight homeostasis. Mutations in this receptor are associated with obese phenotypes. In particular, the present invention relates to identification and characterization of the receptor for leptin, including a naturally occurring soluble form of the receptor that is expected to modulate leptin activity, in particular to agonize leptin activity. The invention further relates to the nucleic acids encoding the receptor, and to methods for using the receptor, e.g., to identify leptin analogs, therapeutically, such as in gene therapy or in soluble form as an agonist or antagonist of leptin activity, or diagnostically.
    Type: Grant
    Filed: February 14, 1996
    Date of Patent: June 20, 2006
    Assignee: The Rockefeller University
    Inventors: Jeffrey M. Friedman, Gwo-Hwa Lee, Ricardo Proenca