Patents by Inventor Gwo-Jaw Wang
Gwo-Jaw Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9415114Abstract: A series of peptides with divergent confirmations including structures of formula (1A), (1B), (2) and (3) are provided. In the formula, wherein U, G, A, B, R1, R2 and T are as defined in the specification. The divergent peptides disclosed in the present invention are characterized in a mineral binding affinity function.Type: GrantFiled: July 22, 2015Date of Patent: August 16, 2016Assignee: Kaohsiung Medical UniversityInventors: Hui-Ting Chen, Kuang-Chan Hsieh, Je-Ken Chang, Gwo-Jaw Wang, Yin-Chih Fu, Mei-Ling Ho, Cherng-Chyi Tzeng
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Patent number: 9314533Abstract: A series of peptides with divergent confirmations including structures of formula (1A), (1B), (2) and (3) are provided. In the formula, wherein U, G, A, B, R1, R2 and T are as defined in the specification. The divergent peptides disclosed in the present invention are characterized in a mineral binding affinity function.Type: GrantFiled: June 27, 2014Date of Patent: April 19, 2016Assignee: KAOHSIUNG MEDICAL UNIVERSITYInventors: Hui-Ting Chen, Kuang-Chan Hsieh, Je-Ken Chang, Gwo-Jaw Wang, Yin-Chih Fu, Mei-Ling Ho, Cherng-Chyi Tzeng
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Patent number: 9314503Abstract: The present invention relates to a hydrophilic drug and ?-tricalcium phosphate (?-TCP) coating on a surface area of biopolymer matrix to form a sustained release system. The present invention also provides a method for preparing a sustained release system, comprising providing a surface are of biopolymer matrix coated with a hydrophilic drug and ?-TCP.Type: GrantFiled: July 8, 2010Date of Patent: April 19, 2016Assignee: KAOHSIUNG MEDICAL UNIVERSITYInventors: Yin-Chin Fu, Chih-Kuang Wang, Gwo-Jaw Wang, Mei-Ling Ho, Je-Ken Chang, Cherng-Chyi Tzeng
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Publication number: 20150320876Abstract: A series of peptides with divergent confirmations including structures of formula (1A), (1B), (2) and (3) are provided. In the formula, wherein U, G, A, B, R1, R2 and T are as defined in the specification. The divergent peptides disclosed in the present invention are characterized in a mineral binding affinity function.Type: ApplicationFiled: July 22, 2015Publication date: November 12, 2015Applicant: KAOHSIUNG MEDICAL UNIVERSITYInventors: Hui-Ting Chen, Kuang-Chan Hsieh, Je-Ken Chang, Gwo-Jaw Wang, Yin-Chih Fu, Mei-Ling Ho, Cherng-Chyi Tzeng
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Patent number: 9173969Abstract: The present invention provides a biomaterial comprising a scaffold consisting of collagen, hyaluronic acid, and gelatin, which are cross-linked via ethyl-3-[3-dimethylaminopropyl]carbodiimide (EDC) between any two of collagen, hyaluronic acid, and gelatin. The present invention further provides a method for preparing the biomaterial and a method for enhancing wound healing with the biomaterial.Type: GrantFiled: April 11, 2012Date of Patent: November 3, 2015Assignee: KAOHSIUNG MEDICAL UNIVERSITYInventors: Hui-Min Wang, Mei-Ling Ho, Gwo-Jaw Wang, Je-Ken Chang, Yi-Ting Chou, Ching-Ying Wu, Su-Shin Lee
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Patent number: 8940203Abstract: The present invention provides a method for preparing a composition comprising porous ceramic, comprising the following steps: (a) synthesizing poly(N-isopropylacrylamide-co-methacrylic acid) (p(NIPAAM-MAA)) or similar thermo-response compound thereof; (b) mixing a dispersant with hydroxyapatite or calcium phosphate salt; (c) mixing the p(NIPAAM-MAA) of the step (a) or similar thermo-response compound thereof with water to obtain a hydrogel solution; (d) mixing the hydrogel solution of the step (c) and product of the step (b) to produce a mixture; (e) adding macromolecular particles to the mixture of the step (d) and stirring to produce a slurry; (f) filling the slurry of the step (e) into a template slot; and disposing the template slot filling with the slurry of the step (f) on a crucible, then proceeding high temperature sinter in a furnace to form the composition comprising porous ceramic.Type: GrantFiled: April 6, 2011Date of Patent: January 27, 2015Assignee: Kaohsiung Medical UniversityInventors: Chih-Kuang Wang, Mei-Ling Ho, Yin-Chih Fu, Gwo-Jaw Wang, Je-Ken Chang
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Publication number: 20140377212Abstract: A series of peptides with divergent confirmations including structures of formula (1A), (1B), (2) and (3) are provided. In the formula, wherein U, G, A, B, R1, R2 and T are as defined in the specification. The divergent peptides disclosed in the present invention are characterized in a mineral binding affinity function.Type: ApplicationFiled: June 27, 2014Publication date: December 25, 2014Applicant: Kaohsiung Medical UniversityInventors: Hui-Ting Chen, Kuang-Chan Hsieh, Je-Ken Chang, Gwo-Jaw Wang, Yin-Chih Fu, Mei-Ling Ho, Cherng-Chyi Tzeng
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Patent number: 8889828Abstract: A series of peptides with divergent confirmations including structures of formula (1A), (1B), (2) and (3) are provided. In the formula, wherein U, G, A, B, R1, R2 and T are as defined in the specification. The divergent peptides disclosed in the present invention are characterized in a mineral binding affinity function.Type: GrantFiled: October 21, 2011Date of Patent: November 18, 2014Assignee: Kaohsiung Medical UniversityInventors: Hui-Ting Chen, Kuang-Chan Hsieh, Je-Ken Chang, Gwo-Jaw Wang, Yin-Chih Fu, Mei-Ling Ho, Cherng-Chyi Tzeng
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Patent number: 8883862Abstract: A method for locally controlled release of an effective amount of PTH(1-34) by a hyaluronic acid based hydrogel that can injected intra-articularly for the treatment of osteoarthritis is provided.Type: GrantFiled: January 12, 2012Date of Patent: November 11, 2014Assignee: Kaohsiung Medical UniversityInventors: Mei-Ling Ho, Rajalakshmanan Eswaramoorthy, Shun-Cheng Wu, Gwo-Jaw Wang, Je-Ken Chang, Yin-Chih Fu, Cherng-Chyi Tzeng, Hui-Ting Chen, Yao-Hsien Wang
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Patent number: 8865220Abstract: The present invention provides a method for producing a controlled release microsphere with mean average size greater than 50 ?m, comprising preparing a water-in-oil (w/o) emulsion comprising an inner aqueous layer containing a pharmaceutically effective amount of a biologically active polypeptide with activity similar to parathyroid hormone, and an oil layer containing a polymer substance of poly(lactic-co-glycolic acid) (PLGA), then adding the w/o emulsion into aqueous polyvinyl alcohol (PVA) solution to form a water-in-oil-in-water (w/o/w) double emulsion and then desorbing the solvent in the oil layer. The present invention also provides a controlled release microsphere prepared by the method and use thereof.Type: GrantFiled: June 14, 2010Date of Patent: October 21, 2014Assignee: Kaohsiung Medical UniversityInventors: Mei-Ling Ho, Gwo-Jaw Wang, Je-Ken Chang, Yin-Chih Fu, Cherng-Chyi Tzeng, Eswaramoorthy Rajalakshmanan
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Patent number: 8663677Abstract: A controlled release system and manufacturing method is provided. The method comprises providing a first aqueous solution containing a hydrophilic drug and an alkaline agent, providing an organic solution containing a hydrophobic molecule, providing a second aqueous solution containing a hydrophilic surfactant, mixing the first hydrophilic solution with the organic solution to form a first emulsion, and mixing the first emulsion with a second aqueous solution to form a second emulsion containing delayed-release microsphere.Type: GrantFiled: August 12, 2011Date of Patent: March 4, 2014Assignee: Kaohsiung Medical UniversityInventors: Yin-Chih Fu, Chih-Kuang Wang, Gwo-Jaw Wang, Mei-Ling Ho, Hui-Ting Chen, Je-Ken Chang, Cherng-Chyi Tzeng
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Patent number: 8586533Abstract: A method for treating early-stage osteoarthritis in an animal is provided. The method comprises delivery of a therapeutically effective amount of a parathyroid hormone (PTH) or a PTH derived substance to an affected joint cavity of the patient. Methods for inhibiting articular chondrocytes apoptosis and for inhibiting a degenerative process of articular chondrocytes in an afflicted animal are also provided.Type: GrantFiled: December 15, 2009Date of Patent: November 19, 2013Assignee: Kaohsiung Medical UniversityInventors: Mei-Ling Ho, Gwo-Jaw Wang, Je-Ken Chang, Yin-Chih Fu, Chung-Hwan Chen
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Publication number: 20130274190Abstract: The present invention provides a biomaterial comprising a scaffold consisting of collagen, hyaluronic acid, and gelatin, which are cross-linked via ethyl-3-[3-dimethylaminopropyl]carbodiimide (EDC) between any two of collagen, hyaluronic acid, and gelatin. The present invention further provides a method for preparing the biomaterial and a method for enhancing wound healing with the biomaterial.Type: ApplicationFiled: April 11, 2012Publication date: October 17, 2013Applicant: KAOHSIUNG MEDICAL UNIVERSITYInventors: Hui-Min WANG, Mei-Ling HO, Gwo-Jaw WANG, Je-Ken CHANG, Yi-Ting CHOU, Ching-Ying WU, Su-Shin LEE
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Patent number: 8530420Abstract: A method for treating and/or inhibiting arthritis is provided. The method includes administering an effective amount of a composition including a parathyroid hormone and a pharmaceutically acceptable carrier or salt to a subject with arthritis. Additionally, a method for inhibiting and/or rescuing terminal differentiation of cells is also provided.Type: GrantFiled: December 16, 2008Date of Patent: September 10, 2013Assignee: Kaohsiung Medical UniversityInventors: Mei-Ling Ho, Gwo-Jaw Wang, Je-Ken Chang, Yin-Chih Fu, Chung-Hwan Chen
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Publication number: 20130183349Abstract: A method for locally controlled release of an effective amount of PTH(1-34) by a hyaluronic acid based hydrogel that can injected intra-articularly for the treatment of osteoarthritis is provided.Type: ApplicationFiled: January 12, 2012Publication date: July 18, 2013Applicant: KAOHSIUNG MEDICAL UNIVERSITYInventors: Mei-Ling Ho, Rajalakshmanan Eswaramoorthy, Shun-Cheng Wu, Gwo-Jaw Wang, Je-Ken Chang, Yin-Chih Fu, Cherng-Chyi Tzeng, Hui-Ting Chen, Yao-Hsien Wang
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Publication number: 20130171197Abstract: The present invention provides a hydrogel comprising a poly(N-isopropylacrylamide) cross-linked hyaluronic acid. The present invention also provides a method of synthesizing a hydrogel comprising poly(N-isopropylacrylamide) cross-linked hyaluronic acid, which comprises (a) synthesizing methacrylated hyaluronic acid; and (b) copolymerizing methacrylated hyaluronic acid with N-isopropylacrylamide.Type: ApplicationFiled: December 28, 2011Publication date: July 4, 2013Applicant: KAOHSIUNG MEDICAL UNIVERSITYInventors: Mei-Ling Ho, Rajalakshmanan Eswaramoorthy, Shun-Cheng Wu, Gwo-Jaw Wang, Je-Ken Chang, Yin-Chih Fu, Cherng-Chyi Tzeng, Chau-Zen Wang
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Patent number: 8470522Abstract: Disclosed herein is a three-dimensional culture containing human articular chondrocytes with induced terminal differentiation changes, as well as a process for preparing the same. The three-dimensional culture, which was found to mimic the biological characteristics of articular chondrocytes that undergo terminal differentiation in vivo, can be used as a tool in the studies of the molecular and cellular mechanisms of osteoarthritis, and in the screening of candidate drugs for use in treatment of a disorder associated with articular chondrocytes.Type: GrantFiled: July 20, 2006Date of Patent: June 25, 2013Assignee: Kaohsiung Medical UniversityInventors: Mei-Ling Ho, Gwo-Jaw Wang, Je-Ken Chang
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Publication number: 20120270811Abstract: A series of peptides with divergent confirmations including structures of formula (1A), (1B), (2) and (3) are provided. In the formula, wherein U, G, A, B, R1, R2 and T are as defined in the specification. The divergent peptides disclosed in the present invention are characterized in a mineral binding affinity function.Type: ApplicationFiled: October 21, 2011Publication date: October 25, 2012Applicant: KAOHSIUNG MEDICAL UNIVERSITYInventors: Hui-Ting Chen, Kuang-Chan Hsieh, Je-Ken Chang, Gwo-Jaw Wang, Yin-Chih Fu, Mei-Ling Ho, Cherng-Chyi Tzeng
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Patent number: 8138184Abstract: An isoxazole derivative is provided. The isoxazole derivative has following formula: wherein R1, R2, R3, R4 and R5, independently, include hydrogen, hydroxy or C1-C12 alkoxy optionally substituted with oxirane, thiirane, aziridine, amino, cycloamino, aminohydroxy or cycloaminohydroxy. The invention also provides a pharmaceutical composition for treatment of osteoporosis and cancer including an isoxazole derivative or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.Type: GrantFiled: October 1, 2008Date of Patent: March 20, 2012Assignee: Kaohsiung Medical UniversityInventors: Cherng-Chyi Tzeng, Yeh-Long Chen, Gwo-Jaw Wang, Mei-Ling Ho, Je-Ken Chang, Yin-Chih Fu
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Publication number: 20110318331Abstract: A novel nanoparticle and use thereof were provided in the present invention. In particular, the nanoparticle is used for delivering therapeutic component, such as oligonucleotide and hydrophobic drug.Type: ApplicationFiled: June 29, 2010Publication date: December 29, 2011Applicant: KAOHSIUNG MEDICAL UNIVERSITYInventors: Chih-Kuang Wang, Gwo-Jaw Wang, Mei-Ling Ho, Cherng-Chyi Tzeng, Je-Ken Chang, Yin-Chih Fu