Abstract: The invention provides compounds that modulate the activity of protein kinases that are associated with human diseases, disorders, and conditions. In particular, compounds of the invention inhibit TYK2, a member of the Janus Kinase (JAK) family of non-receptor protein kinases.

Abstract: In some examples, a security application may monitor data received from one or more of sensors of a computing device, one or more input devices of the computing device, or one or more biometric sensors of a smartwatch that is connected to the computing device. If the user is not logged in and the user that is carrying the computing device has an uneven gait or is stumbling, the security app may, when the user initiates a login process, gather additional data, such as, from the sensors, the smartwatch, or both. If the user makes too many errors, based on data from the input devices, when attempting to login or after logging in, the security application may gather additional data. If the additional data indicates that the user may be under the influence of prescription or recreational drugs or alcohol, the user may be prevented from logging in.

Abstract: Methods, apparatus, and processor-readable storage media for generating context-based question-answer pairs by applying artificial intelligence techniques to context-related data are provided herein.

Abstract: An apparatus comprises at least one processing device configured to perform steps of receiving a request to determine a path to a given web element of a web page of a web application and parsing the web page to detect web elements of the web page including the given web element and one or more additional web elements. The at least one processing device is also configured to perform steps of identifying one or more of the additional web elements having designated characteristics and selecting one of the identified web elements based at least in part on locations of the identified web elements, relative to the given web element, in a tree structure of the web page. The at least one processing device is further configured to perform the step of determining the path to the given web element from the selected web element.

Abstract: A method for automatically linking accounts in an electronic wallet includes: receiving first account data corresponding to a first portable financial device stored in an electronic wallet; determining user information corresponding to the first account data; determining, based on the user information, whether a second portable financial device is associated with the user; determining second account data corresponding to the second portable financial device, wherein the second account data is not stored in the electronic wallet corresponding to the user; and automatically linking the second account data to the electronic wallet. A system and computer program product for automatically linking accounts in the electronic wallet are also disclosed.

Abstract: In some examples, a security application may monitor data received from one or more of sensors of a computing device, one or more input devices of the computing device, or one or more biometric sensors of a smartwatch that is connected to the computing device. If the user is not logged in and the user that is carrying the computing device has an uneven gait or is stumbling, the security app may, when the user initiates a login process, gather additional data, such as, from the sensors, the smartwatch, or both. If the user makes too many errors, based on data from the input devices, when attempting to login or after logging in, the security application may gather additional data. If the additional data indicates that the user may be under the influence of prescription or recreational drugs or alcohol, the user may be prevented from logging in.

Abstract: An apparatus comprises at least one processing device configured to perform steps of receiving a request to determine a path to a given web element of a web page of a web application and parsing the web page to detect web elements of the web page including the given web element and one or more additional web elements. The at least one processing device is also configured to perform steps of identifying one or more of the additional web elements having designated characteristics and selecting one of the identified web elements based at least in part on locations of the identified web elements, relative to the given web element, in a tree structure of the web page. The at least one processing device is further configured to perform the step of determining the path to the given web element from the selected web element.

Abstract: In some examples, a computing device may receive a request for a video segment captured by a particular camera, where the request specifies a date, a start time, and a length of the video segment. The computing device may identify stored data associated with the video segment in a storage device based on the date, the start time, the length, and an identifier associated with the particular camera and retrieve the stored data from the storage device. The computing device may determine that the stored data includes a subset of the video frames that were sent from the particular camera and excludes a remainder of the video frames and regenerate the remainder of the video frames based on the stored data to create regenerated data. The computing device may reconstruct the reconstructed video segment by merging the stored data with the regenerated data and provide the reconstructed video segment.

Abstract: Methods, apparatus, and processor-readable storage media for generating context-based question-answer pairs by applying artificial intelligence techniques to context-related data are provided herein.

Abstract: Methods, apparatus, and processor-readable storage media for evaluations performed by applying machine learning and artificial intelligence techniques to multi-modal data are provided herein.

Abstract: In some examples, a computing device may receive a request for a video segment captured by a particular camera, where the request specifies a date, a start time, and a length of the video segment. The computing device may identify stored data associated with the video segment in a storage device based on the date, the start time, the length, and an identifier associated with the particular camera and retrieve the stored data from the storage device. The computing device may determine that the stored data includes a subset of the video frames that were sent from the particular camera and excludes a remainder of the video frames and regenerate the remainder of the video frames based on the stored data to create regenerated data. The computing device may reconstruct the reconstructed video segment by merging the stored data with the regenerated data and provide the reconstructed video segment.

Abstract: A method for automatically linking accounts in an electronic wallet includes: receiving first account data corresponding to a first portable financial device stored in an electronic wallet; determining user information corresponding to the first account data; determining, based on the user information, whether a second portable financial device is associated with the user; determining second account data corresponding to the second portable financial device, wherein the second account data is not stored in the electronic wallet corresponding to the user; and automatically linking the second account data to the electronic wallet. A system and computer program product for automatically linking accounts in the electronic wallet are also disclosed.

Abstract: Disclosed are compositions and methods for amplification of nucleic acid sequences of interest with greater efficiency and fidelity. The disclosed method relates to isothermal amplification techniques, such as Multiple Displacement Amplification (MDA), where the generation of DNA artifacts is decreased or eliminated. Generally, this can be accomplished by carrying out the reaction at elevated temperature. In particularly useful embodiments of the method, sugars and/or other additives can be used to stabilized the polymerase at high temperature. It has been discovered that generation of high molecular weight artifacts, in an isothermal amplification procedure, is substantially reduced or eliminated while still allowing the desired amplification of input DNA by carrying out the reaction at a higher temperature and, optionally, in the presence of one or more additives.

Abstract: A method is disclosed in which circular DNA molecules are amplified preferentially in a mixture of circular DNA molecules and linear DNA molecules by the inclusion of single strand DNA binding protein.

Abstract: The present invention provides methods, formulation and kits for the synthesis of long nucleic acid fragments. An improved PCR method is provided for amplifying long DNA fragments. In particular, a single thermostable DNA polymerase is used for the rapid amplification of over 10 kb long DNA fragments. Also provided is a method for extending long complementary DNA strands using this single enzyme formulation.

Abstract: Improved processes for the amplification of target DNA sequences in the form of single or double stranded circular DNA molecules, especially those present in colony and plaque extracts, using multiple specific and/or random sequence oligonucleotide primers are disclosed. The product of this amplification is used for analysis by restriction enzyme digestion or DNA sequencing and other analyses that involve hybridization. Kits containing components for use in the method are also described. Also described are further uses of this amplified DNA in sequencing, genotyping and haplotyping, and other molecular biology applications.

Abstract: The present invention provides methods, formulation and kits for the synthesis of long nucleic acid fragments. An improved PCR method is provided for amplifying long DNA fragments. In particular, a single thermostable DNA polymerase is used for the rapid amplification of over 10 kb long DNA fragments. Also provided is a method for extending long complementary DNA strands using this single enzyme formulation.

Abstract: Disclosed are compositions and methods for detecting small quantities of analytes such as proteins and peptides. The method involves associating a DNA circle with the analyte and subsequent release and rolling circle replication of the circular DNA molecule. In the method, an amplification target circle is associated with analytes using a conjugate of the circle and a specific binding molecule that is specific for the analyte to be detected. Amplification target circles not associated with the proteins are removed, the amplification target circles that are associated with the proteins are decoupled from the specific binding molecule and amplified by rolling circle amplification. The amplification is isothermic and can result in the production of a large amount of nucleic acid from each primer. The amplified DNA serves as a readily detectable signal for the analytes.

Abstract: The present disclosure provides a composition for enhancing effect of an inhibitor in inhibiting NAD+/NADP+ or NADH/NADPH dependent enzymes. The inhibition of the NAD+/NADP+ or NADH/NADPH dependent enzymes such as Enoyl-ACP reductase (ENR) by the composition of the present disclosure serves as a target for treating malaria and other infectious diseases. The present disclosure provides composition comprising inhibitor and polyphenol, wherein the polyphenol was found to enhance the inhibitory activity of the inhibitor. The present disclosure provides method for treating an infectious disease comprising administering an effective amount of the composition of the present disclosure to patients in need thereof.

Abstract: The current invention presents enoyl-ACP reductase, an enzyme of the type II fatty acid synthesis pathway as a target for treating human malarias and other infectious diseases. We also present in the current invention, 2-thioxothiazolidin-4-ones as antimicrobial and antimalarial agents. We provide 2-thioxothiazolidin-4-ones as antimicrobial and antimalarial agents either alone or in combination with other known antimicrobial and antimalarial agents with or without added adjuvants or diluents or carriers.