Abstract: The present disclosure relates to a coronavirus-specific double-stranded oligonucleotide and a use thereof. The present disclosure induces RNA interference specific to a coronavirus, particularly, to SARS-CoV, SARS-CoV-2, and a mutant thereof so as to effectively inhibit viral infection and proliferation, and is nearly unaffected by viral variants since a conserved sequence is mainly targeted. Therefore, the double-stranded oligonucleotide of the present disclosure may be effectively used in proliferation inhibition, infection prevention, and disease treatment of the coronavirus, and particularly, may be effectively used as an agent for preventing and treating COVID-19, which is the cause of the current pandemic.

Abstract: The present invention relates to a humanized antibody specific to a Bacillus anthracis protective antigen and a preparation method thereof. An antibody library is created by obtaining a Bacillus anthracis protective antigen antibody of a monkey from immune cells obtained by immunizing a Bacillus anthracis protective antigen, an antibody specific to the Bacillus anthracis protective antigen is selected from the created antibody library, and, on the basis of the antibody, a humanized antibody specific to the Bacillus anthracis protective antigen is finally selected by creating a humanized antibody library against a Bacillus anthracis protective antigen.