Patents by Inventor Gyorgy Hajos
Gyorgy Hajos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4428938Abstract: Peptides affecting the immune regulation selected from the following group:Arg-Lys-AspArg-Lys-Asp-ValArg-Lys-Asn-ValArg-Lys-Asu-ValArg-Lys-Ala-ValArg-Lys-Asp-AlaArg-Lys-Asp-IleArg-Lys-Glu-ValArg-Ala-Asp-ValArg-Asp-Lys-ValAla-Lys-Asp-ValLys-Arg-Asp-ValGlp-Arg-Lys-AspGlp-Arg-Lys-Asp-ValGlp-Arg-Lys-Asp-Val-Tyr and salts, amides lower alkyl esters and protected derivatives thereof.Type: GrantFiled: June 11, 1982Date of Patent: January 31, 1984Assignee: Richter Gedeon Vegyeszeti Gyar Rt.Inventors: Lajos Kisfaludy, Olga Nyeki nee Kuprina, Istvan Schon, Laszlo Denes, Julia Ember, Gyorgy Hajos, Laszlo Szporny, Bela Szende
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Patent number: 4419355Abstract: The invention relates to new condensed as-triazine derivatives of the general formula (I) ##STR1## wherein Z represents a buta-1,3-dienyl group or a group of the formula (a), (b), (c) or (d) ##STR2## R.sub.1 denotes a C.sub.1-10 alkyl group, an oxo group or a C.sub.6-10 aryl or C.sub.6-10 aryl-(C.sub.1-3 alkyl) group optionally substituted by one or more identical or different substituents selected from the group consisting of amino, nitro, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, hydroxy and halogen,R.sub.2 stands for hydrogen, C.sub.1-10 alkyl or amino,R.sub.3 represents hydrogen, C.sub.1-10 alkyl or C.sub.6-10 aryl or C.sub.6-10 aryl-(C.sub.1-3 alkyl) optionally substituted by one or more identical or different substituents selected from the group consisting of nitro, amino, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, hydroxy and halogen,X.sup.- denotes an anion, andn is 0 or 1,with the proviso that if n is O, R.sub.1 is other than an oxo group and R.sub.1 ' and R.sub.Type: GrantFiled: July 16, 1981Date of Patent: December 6, 1983Assignee: Egyt Gyogyszervegyeszeti GyarInventors: Ibolya Kosoczky, Eva Toncsev, nee Ravasz, Pal Benko, Laszlo Pallos, Lujza Petocz, Sandor Batori, Gyorgy Hajos, Andras Messmer, Katalin Grasser
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Patent number: 4324786Abstract: New pyrido[2,3-e]-as-triazine derivatives of the general formula (I), ##STR1## wherein R.sup.1 and R.sup.2 each stand for a C.sub.1-20 alkylcarbonyl, halogenated (C.sub.1-4 alkyl)-carbonyl, C.sub.1-4 alkoxycarbonyl, benzoyl, phenyl-(C.sub.1-4 alkyl)-carbonyl or phenyl-(C.sub.2-4 alkenyl)-carbonyl group or a 5-10-membered mono- or bicyclic nitrogen-containing heterocyclic acid residue (preferably a pyridylcarbonyl group) containing optionally one or more additional nitrogen, oxygen and/or sulfur atoms in the heterocyclic ring, and optionally one or more identical or different substituents selected from the group consisting of halogen, C.sub.1-4 alkoxy, nitro and hydroxy are attached to the aromatic or heterocyclic rings, furthermore one of R.sup.1 and R.sup.2 may also stand for hydrogen atom, orR.sup.1 and R.sup.2 may form, together with the adjacent nitrogen atoms, a pyrazole-2,4 ring having optionally a C.sub.1-6 alkyl substituent in position 3, andR.sup.3 stands for hydrogen, halogen, C.sub.Type: GrantFiled: April 25, 1980Date of Patent: April 13, 1982Assignee: Egyt Gyogyszervegyeszeti GyarInventors: Andras Messmer, Pal Benko, Gyorgy Hajos, Lujza Petocz, Ibolya Kosoczky, Peter Gorog
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Patent number: 4324894Abstract: Novel aminoisoquinoline derivatives of the general formula (I) ##STR1## wherein R.sub.1 represents a hydrogen atom or a C.sub.1-4 alkyl group,R.sub.2 represents a hydrogen atom,R.sub.3 represents a hydrogen atom,R.sub.4 represents a morpholinyl group or a piperazinyl group substituted with a pyridyl group, andpharmaceutically acceptable acid addition salts and quaternary derivatives thereof have been prepared. The novel compounds exert narcosis potentiating effects.Type: GrantFiled: April 10, 1980Date of Patent: April 13, 1982Assignee: Egyt Gyogyszervegyeszeti GyarInventors: Pal Benko, Andras Gelleri, Gyorgy Hajos, Andras Messmer, Laszlo Pallos, Lujza Petocz, Ibolya Kosoczky, Katalin Grasser, Peter Gorog, Eniko Szirt nee Kiszelly
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Patent number: 4320127Abstract: The invention relates to new pyrido[3,2-e]-as-triazine derivatives of the formula I and pharmaceutically acceptable acid addition salts thereof, ##STR1## wherein R.sub.1 stands for a C.sub.1-20 alkyl-carbonyl group, halogen-C.sub.1-4 alkyl-carbonyl, benzoyl, phenyl-C.sub.1-4 alkyl-carbonyl, or pyridyl-carbonyl group;R.sub.2 is a hydrogen atom or a C.sub.1-4 alkyl-carbonyl group; or R.sub.1 and R.sub.2 form together with the adjacent nitrogen atoms a pyrazole-2,4-dione ring which carries a C.sub.1-6 alkyl substituent in position 3;R.sub.3 is a hydrogen atom, a C.sub.1-20 alkyl, phenyl, phenyl-C.sub.1-3 alkyl, furyl or pyridyl group or a phenyl group optionally substituted by one to three C.sub.1-4 alkoxy-groups.The compounds of the formula I are prepared by acylating the respective 1,2-un-substituted 1,2-dihydropyrido [3,2-e]-as-triazine derivatives. The new compounds exert valuable effects on the central nervous system and possess analgesic, antiphlogistic effects, and can be applied to advantage in therapy.Type: GrantFiled: May 23, 1980Date of Patent: March 16, 1982Assignee: Edyt Gyogyszervegyeszeti GyarInventors: Pal Benko, Andras Messmer, Gyorgy Hajos, Sandor Batori, Lujza Petocz, Iboly Kosoczky, Peter Gorog
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Patent number: 4316022Abstract: The invention relates to new benzo-as-triazine derivatives of the formulae (I) and (Ia) and pharmaceutically acceptable acid addition salts thereof, ##STR1## wherein R.sub.1 and R.sub.2 each represent hydrogen, a C.sub.1-20 alkylcarbonyl group, a phenylcarbonyl or phenyl-(C.sub.1-4 alkyl)-carbonyl group having optionally one or more halogen, hydroxy or C.sub.1-3 alkoxy substituents which may be the same or different, furthermore a pyridylcarbonyl, a pyrazinylcarbonyl, a furylcarbonyl, a chloroacetyl or a C.sub.1-4 alkoxycarbonyl group, orR.sub.1 and R.sub.2 may form, together with the adjacent nitrogen atoms, a pyrazole ring having optionally a C.sub.1-6 alkyl substituent in position 4,with the proviso that one of R.sub.1 and R.sub.2 is always different from hydrogen,R.sub.3 stands for hydrogen, mercapto group, a C.sub.1-4 alkylmercapto group, amino group, a C.sub.1-4 alkylamino group, a piperazino group having optionally an N-alkyl or 2-pyridyl substituent, a morpholino group or a piperidino group, andR.sub.Type: GrantFiled: March 28, 1980Date of Patent: February 16, 1982Assignee: EGYT Gyogyszervegyeszeti GyarInventors: Gyorgy Hajos, Andras Messmer, Pal Benko, Lujza Petocz, Peter Gorog, Ibolya Kasoczky
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Patent number: 4200631Abstract: Ulcer production in animals is prevented during prolonged antiphlogistic treatment with ulcerogenic quantities of indomethacin by using it in a composition of 1 part of indomethacin to 7.5 to 25 parts, preferably 10 parts by weight of a salicylate. Indomethacin is the most potent ulcerating compound among approved non-steroid antiinflammatory agents.Type: GrantFiled: August 8, 1978Date of Patent: April 29, 1980Assignee: Richter Gedeon Vegyeszeti Gyar Rt.Inventors: Elemer Ezer, Laszlo Szporny, Lilla Forgach, Eva Palosi, Eszter Cholnoky, Egon Karpati, Gyorgy Hajos, Gyozo Hortobagyi, Katalin Gidai
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Patent number: 4198402Abstract: Ulcer production in animals is prevented during prolonged antiphlogistic treatment with ulcerogenic quantities of phenylbutazone by using it in a composition of 1 part of antiphlogistic to 0.2 to 50 parts by weight of alkali metal salicylate.Type: GrantFiled: April 3, 1978Date of Patent: April 15, 1980Assignee: Richter Gedeon Vegyeszeti Gyar Rt.Inventors: Elemer Ezer, Laszio Szporny, Lilla Forgach, Eva Palosi, Eszter Cholnoky, Egon Karpati, Gyorgy Hajos, Gyozo Hortobagyi, Katalin Gidai
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Patent number: 4058522Abstract: A compound of the following formula: ##STR1## wherein X.sub.1 is hydrogen or mercapto;X.sub.2 is mercapto or acetylthio;X.sub.3 is hydrogen or acetylthio; andX.sub.4 is hydrogen, acetylthio or X.sub.3 and X.sub.4 together form a valence bond, but if X.sub.3 and X.sub.4 form a valence bond X.sub.2 is mercapto. The compounds are useful in the treatment of heavy-metal poisoning.Type: GrantFiled: July 16, 1976Date of Patent: November 15, 1977Assignee: Richter Gedeon Vegyeszeti Gyar Rt.Inventors: Tibor Kekesy, Szabolcs Szeberenyi, Gyorgy Beer, Antal Dudas, Gyorgy Hajos, Laszlo Szporny, Eva Czajlik, nee Csizer
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Patent number: 4017507Abstract: New tricyclic fused imidazole derivatives of the general formula (I), ##STR1## wherein R.sub.1 stands for hydrogen or hydroxy,n is equal to zero or one,m is equal to zero, one or two,A stands for a group of the general formula (II), ##STR2## wherein R.sub.2 represents hydrogen or hydroxy,R.sub.3 represents hydrogen or amino, orQ and Z each stand for nitrogen or a=C-- group, orA stands for a group of the general formula (III), ##STR3## wherein R.sub.4 and R.sub.5 each represent hydrogen, methyl, chlorine or nitro,Were prepared by reacting a compound of the general formula (IV) ##STR4## wherein A and n each have the same meanings as defined above, with a compound of the general formula (V), ##STR5## wherein X stands for halogen, R.sub.6 stands for hydrogen and R.sub.7 stands for a group of the general formula (VI),--(ch.sub.2).sub.m --X VI.in which m and X each have the same meanings as defined above, or R.sub.6 and R.sub.7 together stand for oxygen.Type: GrantFiled: December 5, 1975Date of Patent: April 12, 1977Assignee: Richter Gedeon Vegyeszeti Gyar Rt.Inventors: Kalman Hideg, Olga Hankovszky, Eva Palosi, Gyorgy Hajos, Laszlo Szporny
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Patent number: 3988322Abstract: Pharmaceutically active steroids of the formula (I) ##SPC1##whereinX.sub.1 and X.sub.2 each is hydrogen, mercapto or acetylthio andX.sub.3 and X.sub.4 each is hydrogen or acetylthio orX.sub.3 and X.sub.4 form together a valence bond, with the proviso that at least one of X.sub.1 to X.sub.4 is selected from the group consisting of mercapto and acetylthio. The compounds are prepared as follows: a compound of the formula (III) ##SPC2##wherein Z.sub.1 is hydrogen and Z.sub.2 is hydrogen or acetylthio or Z.sub.1 and Z.sub.2 form together a valence bond, is brominated, the thus-obtained compound of the formula ##SPC3##Wherein Y.sub.1 and Y.sub.2 each is hydrogen or bromine, Y.sub.3 is bromine, Y.sub.4 is hydrogen or acetylthio or Y.sub.3 and Y.sub.4 form together a valence bond, is reacted with an alkali methal thioacetate or with an alkali metal hydrosulphide. Thioacetic acid can be coupled onto the obtained product, and/or optionally the obtained thioacetyl compound can be subjected to alcoholysis.Type: GrantFiled: June 20, 1974Date of Patent: October 26, 1976Assignee: Richter Gedeon Vegyeszeti Gyar Rt.Inventors: Tibor Kekesy, Szabolcs Szeberenyi, Gyorgy Beer, Antal Dudas, Gyorgy Hajos, Laszlo Szporny, Eva Czajlik nee Csizer
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Patent number: 3932395Abstract: New tricyclic fused imidazole derivatives of the general formula (I), ##SPC1##whereinR.sub.1 stands for hydrogen or hydroxy,n is equal to zero or one,m is equal to zero, one or two,A stands for a group of the general formula (II), ##EQU1## wherein R.sub.2 represents hydrogen or hydroxy,R.sub.3 represents hydrogen or amino, orQ and Z each stand for nitrogen or a =C-- group, orA stands for a group of the general formula (III), ##EQU2## wherein R.sub.4 and R.sub.5 each represent hydrogen, methyl, chlorine or nitro,Were prepared by reacting a compound of the general formula (IV) ##SPC2##wherein A and n each have the same meanings as defined above, with a compound of the general formula (V), ##EQU3## wherein X stands for halogen, R.sub.6 stands for hydrogen and R.sub.7 stands for a group of the general formula (VI),--(CH.sub.2).sub.m --X (VI)in which m and X each have the same meanings as defined above, or R.sub.6 and R.sub.7 together stand for oxygen.Type: GrantFiled: May 24, 1974Date of Patent: January 13, 1976Assignee: Richter Gedeon Vegyeszeti Gyar Rt.Inventors: Kalman Hideg, Olga Hankovszky, Eva Palosi, Gyorgy Hajos, Laszlo Szporny