Abstract: The present invention provides compounds of formula (I) and/or salts thereof and/or biologically active metabolites thereof and/or prodrugs thereof and/or solvates thereof and/or hydrates thereof and/or polymorphs thereof having affinity and selectivity for the gamma-aminobutyric acid A receptor subunit alpha 5 and act as GABAA ?5 positive allosteric modulators, thereby useful in the treatment or prevention of diseases related to the GABAA ?5 receptor, process for the preparation and intermediates of the preparation process thereof, pharmaceutical compositions comprising them alone or in combination with one or more other active ingredients and their use as medicaments.

Abstract: A scanning system provides for scanning documents and generating respective electronic copies with associated metadata. A scanner scans one or more documents to produce respective electronic copies. A user interface captures metadata entered by a user regarding the documents. A controller is communicatively coupled to the scanner and the user interface, and enables the user interface to capture the metadata concurrently with the scanner's scanning the documents. The electronic copy and the metadata can be associated with one another or incorporated into a common file. Parallel metadata entry and physical scanning reduces time a user spends to perform the overall process, resulting in increased user satisfaction.

Abstract: A scanning system provides for scanning documents and generating respective electronic copies with associated metadata. A scanner scans one or more documents to produce respective electronic copies. A user interface captures metadata entered by a user regarding the documents. A controller is communicatively coupled to the scanner and the user interface, and enables the user interface to capture the metadata concurrently with the scanner's scanning the documents. The electronic copy and the metadata can be associated with one another or incorporated into a common file. Parallel metadata entry and physical scanning reduces time a user spends to perform the overall process, resulting in increased user satisfaction.

Abstract: For manufacturing articles of plastics, rubber or any other material a mold or die assembly comprising a mold or die base assembled from repetitive modular standard elements consisting of substantially "ready to use" interchangeable base plates is provided by the invention.The base plates are prefabricated by high-precision castings or galvanoplastics or any other similar high-precisious non-cutting method of manufacture.At least two of such base plates are, as mold or die plates, provided with a pre-determined number and arrangement of finished to sized, prefabricated cylindrical bores or piercings of any non-circular, mainly polygonal cross-section. Each of said bores or piercings is capable of fittingly receiving an interchangeable mold or die insert carrying the individually designed (negative) mold or die cavity surface for forming the particular article(s) to be manufactured.