Patents by Inventor Gyorgy Mathe

Gyorgy Mathe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • N-([1,4]benzodioxan-2-ylmethyl)-N-(3-chloro-1-propyl)-amine
    Patent number: 6248907
    Abstract: The invention relates to R-2-[3-([1,4]benzodioxan-2-ylmethylamino)-1-propyl]-3(2H)-pyridazinone of formula (1), and to S-2-[3-([1,4]benzodioxan-2-ylmethylamino)-1-propyl]-3(2H)-pyridazinone of formula (2), and to acid-addition salts thereof as well as pharmaceutical compositions containing these compounds. Furthermore, the invention relates to a process for the preparation of the above compounds. The new starting compounds of formulae (4) and (5) are also involved in the scope of the invention. The compounds according to the invention possess &agr;1- and &agr;2-adrenoceptor antagonistic effects and urogenital selectivity. Thus, they are useful for the treatment of the benign prostate hyperplasia.
    Type: Grant
    Filed: August 28, 2000
    Date of Patent: June 19, 2001
    Assignee: Gyogyszerkutato Intezet Kft.
    Inventors: Péter Mátyus, László Hársing, Marianne Tapfer née Karim, Judit Kosáry, Ágnes Papp née Behr, Antal Simay, Yemane Tilahun, Éva Tomori née Joszt, Edit Horváth, Katalin Horváth, Ildikó Varga, Erzsébet Zára née Kaczián, Margit Bidló née Iglóy, Alice Druga, György Rabloczky, Márta Varga, Egon Kárpáti, Endre Kasztreiner, István Király, Ildikó Máthé née Gyóry, György Máthé, László Sebestyén, Nándor Makk
  • 3(2H)-pyridazinone derivatives and pharmaceutical compositions containing these compounds
    Patent number: 6194411
    Abstract: The invention relates to R-2-[3-([1,4]benzodioxan-2-ylmethylamino)-1-propyl]-3(2H)-pyridazionone of formula (1) and to S-2-[3-([1,4]benzodioxan-2-ylmethylamino)-1-propyl]-3(2H)-pyridazionone of formula (2) and to acid-addition salts thereof as well as pharmaceutical compositions containing these compounds. Furthermore, the invention relates to a process for the preparation of the above compounds. The new starting compounds of formula (4) and (5) are also involved in the scope of the invention. The compounds according to the invention possess &agr;1- and &agr;2-adrenoceptor antagonistic effects and urogenital selectivity. Thus, they are useful for the treatment of the benign prostate hyperplasia.
    Type: Grant
    Filed: July 20, 1998
    Date of Patent: February 27, 2001
    Assignee: Gyogyszerkutato Intezet Kft.
    Inventors: Péter Mátyus, László Hársing, Mariann née Tapfer Karim, Judit Kosáry, Ágnes née Behr Papp, Antal Simay, Yemane Tilahun, Éva née Joszt Tomori, Edit Horváth, Katalin Horváth, Ildikó Varga, Erzsébet née Kaczián Zára, Margit née Iglóy Bidló, Alice Druga, György Rabloczky, Márta Varga, Egon Kárpáti, Endre Kasztreiner, István Király, Ildikó née Gyóry Máthé, György Máthé, László Sebestyén, Nándor Makk
  • 1,3,4-benzotraizepin-5(4H)-one derivatives and process for the preparation thereof
    Patent number: 5441948
    Abstract: The invention relates to racemic or optically active 1,3,4-benzotriazepin-5(4H)-one derivatives, a process for the preparation thereof, pharmaceutical compositions comprising the same, to the use of the said compounds for the treatment of diseases and for the preparation of pharmaceutical compositions containing the said compounds as active agent.The new compounds according to the invention correspond to the general formula (I), ##STR1## wherein R.sup.1 represents hydrogen or straight or branched chain C.sub.1-4 alkyl optionally carrying a pyridyl or a phenyl substituent;R.sup.2 stands for cyanoimino;R.sup.3 denotes hydrogen or straight or branched chain C.sub.1-4 alkyl;R.sup.4 stands for C.sub.1-4 alkyl; andthe dotted line does not represent a valency bond; orR.sup.2 stands for a group of the formula R.sup.9 R.sup.10 N, whereinR.sup.9 and R.sup.10 are independently hydrogen or straight or branched chain C.sub.1-10 alkyl, orR.sup.9 R.sup.10 N together form a 5- to 7-membered heterocyclic group; orR.sup.9 R.
    Type: Grant
    Filed: September 3, 1993
    Date of Patent: August 15, 1995
    Assignee: Egis Gyogyszergyar Rt.
    Inventors: Ilona Bodi, Eva Gal, Melinda Gal, Laszlo Jaszlits, Andrea Jednakovits, Adrina Kiss, Aniko Miklos nee Kovacs, Gyorgy Mathe, Istvan Pallagi, Gyorgy Rabloczky, Antal Simai, Endre Tihanyi