Patents by Inventor Gyorgy Somogyi
Gyorgy Somogyi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20060281155Abstract: The present invention relates to a new microbial process for the preparation of the compound formula (I) from a compound of general formula (II) wherein R stands for an alkali metal or ammonium ion, by the submerged cultivation of a mold strain able to 6?-hydroxylate a compound of the Formula (II) in aerobic fermentation and by the separation and purification of the product of Formula (I) formed in the course of the bioconversion. The process comprises cultivating a strain of Mortierella maculata filamentous mold species that is able to 6?-hydroxylate a compound of the general Formula (II), on a nutrient medium containing assimilable carbon and nitrogen sources and mineral salts and separating the product formed from the fermentation broth, then isolating the compound of formula (I) and purifying the same. Novel strains of Mortierella maculata are also disclosed.Type: ApplicationFiled: August 25, 2006Publication date: December 14, 2006Inventors: Antonia Jekkel, Attila Konya, Istvan Barta, Eva Ilkoy, Gyorgy Somogyi, Gabor Ambrus, Gyula Horvath, Karoly Albrecht, Istvan Szabo, Julianna Suto, Janos Salat, Attila Andor, Laszlo Birincsik, Sandor Boros, Ildiko Lang, Margit Nee Igloy
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Patent number: 6905851Abstract: The present invention relates to a new microbial process for the preparation of compound of formula (I) from a compound of general formula (II) wherein R stands for an alkali metal or ammonium ion, by the submerged culture of a strain which is able to 6?-hydroxylate the compound of formula (II) in aerobic fermentation and by the separation and purification of the product of formula (I) formed in the course of the bioconversion. The latter comprises the cultivation of a Micromonospora strain which is able to 6?-hydroxylate a compound of general formula (II)—wherein R is as defined above—at 25-32° C. on a nutrient medium containing available carbon—and nitrogen sources and mineral salts, thereafter feeding the substrate to be transformed into the developing culture, then hydroxilating the substrate until finishing of the bioconversion, then separating the compound of formula (I) from the culture broth and, if desired, purifying the same.Type: GrantFiled: June 29, 2000Date of Patent: June 14, 2005Assignee: IVAX Drug Research InstituteInventors: Antónia Jekkel, Gábor Ambrus, Éva Ilkóy, Ildikó Horváth, Attila Kónya, István Mihály Szabó, Zsuzsanna Nagy, Gyula Horváth, Júlia Mózes, István Barta, György Somogyi, János Salát, Sándor Boros
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Publication number: 20050124051Abstract: The present invention relates to a new microbial process for the preparation of compound of formula (I) from a compound of general formula (II) wherein R stands for an alkali metal or ammonium ion, by the submerged culture of a strain which is able to 6?-hydroxylate the compound of formula (II) in aerobic fermentation and by the separation and purification of the product of formula (I) formed in the course of the biocoversion. The latter comprises the cultivation of a Micromonospora strain which is able to 6?-hydroxylate a compound of general formula (II)—wherein R is as defined above—at 25-32° C. on a nutrient medium containing available carbon—and nitrogen sources and mineral salts, thereafter feeding the substrate to be transformed into the developing culture, then hydroxilating the substrate until finishing of the bioconversion, then separating the compound of formula (I) from the culture broth and, if desired, purifying the same.Type: ApplicationFiled: December 16, 2004Publication date: June 9, 2005Inventors: Antonia Jekkel, Gabor Ambrus, Eva Ilkoy, Ildiko Horvath, Attila Konya, Istvan Szabo, Zsuzsanna Nagy, Gyula Horvath, Julia Mozes, Istvan Barta, Gyorgy Somogyi, Janos Salat, Sandor Boros
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Patent number: 6750366Abstract: The present invention relates to a new microbial process for the preparation of the compound formula (I): from a compound of general formula (II): wherein R stands for an alkali metal or ammonium ion, by the submerged cultivation of a mold strain able to 6&bgr;-hydroxylate a compound of the Formula (II) in aerobic fermentation and by the separation and purification of the product of Formula (I) formed in the course of the bioconversion. The process comprises cultivating a strain of Mortierella maculata filamentous mold species that is able to 6&bgr;-hydroxylate a compound of the general Formula (II), on a nutrient medium containing assimilable carbon and nitrogen sources and mineral salts and separating the product formed from the fermentation broth, then isolating the compound of formula (I) and purifying the same. Novel strains of Mortierella maculata are also disclosed.Type: GrantFiled: December 5, 2001Date of Patent: June 15, 2004Assignee: Institute for Drug Research Ltd.Inventors: Antonia Jekkel, Attila Konya, Istvan Barta, Eva Ilkoy, Gyorgy Somogyi, Gabor Ambrus, Gyula Horvath, Karoly Albrecht, Istvan Szabo, Julianna Mozes Nee Suto, Janso Salat, Attila Andor, Laszlo Birinesik, Sandor Boros, Ildiko Lang, Margit Bidlo Nee Igloy
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Publication number: 20040039225Abstract: The present invention relates to a new microbial process for the preparation of the compound formula (I) 1Type: ApplicationFiled: August 27, 2003Publication date: February 26, 2004Inventors: Antonia Jekkel, Attila Konya, Istvan Barta, Eva Ilkoy, Gyorgy Somogyi, Gabor Ambrus, Gyula Horvath, Karoly Albrecht, Istvan Szabo, Julianna Mozes Nee Suto, Janso Salat, Attila Andor, Laszlo Birincsik, Sandor Boros, Ildiko Lang, Margit Bidlo Nee Igloy
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Patent number: 6696599Abstract: The present invention relates to a new microbial process for the preparation of the compound formula (I) from a compound of general formula (II) wherein R stands for an alkali metal or ammonium ion, by the submerged cultivation of a mold strain able to 6&bgr;-hydroxylate a compound of the Formula (II) in aerobic fermentation and by the separation and purification of the product of Formula (I) formed in the course of the bioconversion. The process comprises cultivating a strain of Mortierella maculata filamentous mold species that is able to 6&bgr;-hydroxylate a compound of the general Formula (II), on a nutrient medium containing assimilable carbon and nitrogen sources and mineral salts and separating the product formed from the fermentation broth, then isolating the compound of formula (I) and purifying the same. Novel strains of Mortierella maculata are also disclosed.Type: GrantFiled: May 14, 2003Date of Patent: February 24, 2004Assignee: Institute for Drug Research, Ltd.Inventors: Antonia Jekkel, Attila Konya, Istvan Barta, Eva Ilkoy, Gyorgy Somogyi, Gabor Ambrus, Gyula Horvath, Karoly Albrecht, Istvan Szabo, Julianna Mozes Nee Suto, Janso Salat, Attila Andor, Laszlo Birincsik, Sandor Boros, Ildiko Lang, Margit Bidlo Nee Igloy
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Patent number: 6682913Abstract: The present invention relates to a new microbial process for the preparation of the compound formula (I) from a compound of general formula (II) wherein R stands for an alkali metal or ammonium ion, by the submerged cultivation of a mold strain able to 6&bgr;-hydroxylate a compound of the Formula (II) in aerobic fermentation and by the separation and purification of the product of Formula (I) formed in the course of the bioconversion. The process comprises cultivating a strain of Mortierella maculata filamentous mold species that is able to 6&bgr;-hydroxylate a compound of the general Formula (II), on a nutrient medium containing assimilable carbon and nitrogen sources and mineral salts and separating the product formed from the fermentation broth, then isolating the compound of formula (I) and purifying the same. Novel strains of Mortierella maculata are also disclosed.Type: GrantFiled: February 3, 2000Date of Patent: January 27, 2004Assignee: Institute for Drug Research Ltd.Inventors: Antonia Jekkel, Attila Konya, Istvan Barta, Eva Ilkoy, Gyorgy Somogyi, Gabor Ambrus, Gyula Horvath, Karoly Albrecht, Istvan Szabo, Julianna Mozes nee Suto, Janso Salat, Attila Andor, Laszlo Birincsik, Sandor Boros, Ildiko Lang, Margit Bidlo nee Igloy
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Publication number: 20030207413Abstract: The present invention relates to a new microbial process for the preparation of the compound formula (I) 1Type: ApplicationFiled: May 14, 2003Publication date: November 6, 2003Inventors: Antonia Jekkel, Attila Konya, Istvan Barta, Eva Ilkoy, Gyorgy Somogyi, Gabor Ambrus, Gyula Horvath, Karoly Albrecht, Istvan Szabo, Julianna Mozes Nee Suto, Janso Salat, Attila Andor, Laszlo Birincsik, Sandor Boros, Ilidiko Lang, Margit Bidlo Nee Igloy
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Publication number: 20020081675Abstract: The present invention relates to a new microbial process for the preparation of the compound formula (I) 1Type: ApplicationFiled: December 5, 2001Publication date: June 27, 2002Inventors: Antonia Jekkel, Attila Konya, Istvan Barta, Eva Ilkoy, Gyorgy Somogyi, Gabor Ambrus, Gyula Horvath, Karoly Albrecht, Istvan Szabo, Julianna Mozes Nee Suto, Janso Salat, Attila Andor, Laszlo Birinesik, Sandor Boros, Ildiko Lang, Margit Bidlo Nee Igloy
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Patent number: 6075018Abstract: The invention relates to new 1-[2-(substituted vinyl)]-3,4-dihydro-5H-2,3-benzodiazepine derivatives, a process for the preparation thereof and pharmaceutical compositions comprising them. The new 1-[2-(substituted vinyl)]-3,4-dihidro-5H-2,3-benzodiazepine derivatives according to the invention correspond to the general formula (I), ##STR1## wherein the variables are hereinbelow defined: The new compounds according to the invention affect the central nervous system and can be used to advantage in the therapy.Type: GrantFiled: February 9, 1996Date of Patent: June 13, 2000Assignee: Egis Gyogyszergyar Rt.Inventors: Pal Vago, Jozsef Reiter, Istvan Gyertyan, Gabor Gigler, Ferenc Andrasi, Anna Bakonyi, Pal Berzsenyi, Peter Botka, deceased, Erszebet Birkas, Tamas Hamori, Edit Horvath, Katalin Horvath, Jeno Korosi, deceased, Gyorgyne Mate, Imre Moravcsik, Gyorgy Somogyi, Eszter Szentkuti, Gabor Zolyomi
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Patent number: 5288863Abstract: The invention relates to a process for the preparation of 1-(3-chlorophenyl)-4-methyl-7,8-dimethoxy-5 H-2,3-benzodiazepine of formula (I) ##STR1## in high purity and in a quality suitable for pharmaceutical purposes. According to the invention the reaction of 1 mole of 2-acetonyl-3'-chloro-4,5-dimethoxybenzophenone of formula (II) ##STR2## with 3-7 moles of hydrazine hydrate in an organic solvent or in a mixture of organic solvents at a temperature between 15.degree. C. and 85.degree. C. is carried out in the absence of air oxygen, optionally in the presence of water. The crude product is then recrystallized from an aliphatic alcohol containing 1 to 5 carbon atom(s).Type: GrantFiled: May 4, 1992Date of Patent: February 22, 1994Assignee: Egis Gyogyszergyar Rt.Inventors: Gyorgy Somogyi, Peter Botka, Gyula Horvath, Antal Simay, Roozsa Gyenge, Imre Moravcsik, Erno Orban, Tamas Hamori, Jeno Korosi, Csilla Kiss, Tibor Balogh, Maria Bidlo nee Igloi, nee Dievald Uskert
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Patent number: 4851416Abstract: The invention relates to novel racemic or optically active berban derivatives of the formula (I) ##STR1## wherein R.sup.1 and R.sup.2 represent independently from the other a hydroxyl, straight or branched chain alkoxy group 1 to 6 carbon atoms or R.sup.1 and R.sup.2 together represent a C.sub.1-3 alkylenedioxy group;R.sup.3 and R.sup.4 represent independently from the other hydrogen, straight or branched chain alkyl group, having 1 to 6 carbon atoms and optionally substituted by hydroxyl group, or a C.sub.2-6 alkoxycarbonyl or cyano group; andR.sup.5 represents hydrogen, straight or branched chain alkyl group having 1 to 6 carbon atoms, C.sub.1-7 aliphatic or aromatic acyl group or C.sub.1-7 alkylsulphonyl or arylsulphonyl group, anda salt thereof, to pharmaceutical compositions containing them, to the use as well as to process for preparing the novel compounds. The compounds of the formula (I) are selective .alpha..sub.Type: GrantFiled: May 23, 1986Date of Patent: July 25, 1989Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt.Inventors: Szilveszter Vizi, Csaba Szantai, Lajos Szabo, Istvan Toth, Gabor Kovacs, Jeno Marton, Laszlo Harsing, Gyorgy Somogyi, Jozsef Gaal
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Patent number: 4389838Abstract: A single-twist stranding machine includes a stranding disc and nipple for stranding together a plurality of filaments, wires, conductors or the like, a rotatably mounted take-up spool onto which the stranded-together elements are wound, a flyer coaxial with the spool and including a frame and deflection pulleys to run the stranded-together elements from the stranding means to the spool, the flyer revolving about the spool, and a common drive motor. The specific improvement disclosed includes a differential gear transmission having two input gears and an output gear; a first transmission for drivingly connecting the drive motor to the flyer, one of the input gears of the differential gear transmission is a part of the first transmission; a second transmission drivingly connects the output gear to the spool for causing the spool to rotate; and a control drive operates the other input gear to vary the speed relation of flyer and spool in dependance upon the input speed of the stranding elements.Type: GrantFiled: May 7, 1982Date of Patent: June 28, 1983Assignees: Kabelmetal Electro GmbH, Diosgyori GepgyarInventors: Georg Adelhard, Herbert Hasselberg, Manfred Obermeier, Karl Sierwald, Jozsef Szedlacsek, Gyorgy Somogyi