Patents by Inventor Gyula Dekany

Gyula Dekany has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20170313996
    Abstract: Mutated fucosidases are provided demonstrating improved properties in terms of thermal stability and transfucosidase synthetic performance compared with a wild type transfucosidase isolated from Bifidobacterium longum subsp. infantis.
    Type: Application
    Filed: October 23, 2015
    Publication date: November 2, 2017
    Inventors: Elise CHAMPION, Andreas VOGEL, Sebastian BARTSCH, Gyula DEKANY
  • Publication number: 20170175154
    Abstract: The invention relates to a genetically modified microorganism for making a recombinant oligosaccharide, preferably of 3-8 monosaccharide units, more preferably of 3-5 monosaccharide units, particularly a HMO, which comprises one or more genes encoding a sucrose utilization system, so the microorganism can use sucrose as a carbon and energy source. The one or more genes encoding a sucrose utilization system are preferably one or more genes encoding a heterologous PTS-dependent sucrose utilization transport system, such as the scr genes.
    Type: Application
    Filed: June 29, 2015
    Publication date: June 22, 2017
    Applicant: GLYCOM A/S
    Inventors: Eric Samain, Pauline Peltier-Pain, Katrine Bych, Ted Johanson, Elise Champion, Gyula Dekany
  • Publication number: 20160289721
    Abstract: A method of diversification of human milk oligosaccharides (HMOs) or precursors thereof, compounds obtainable by the method, and uses and compositions involving such compounds. The method comprises a) providing at least one compound or a mixture of the compounds selected from the group consisting of: optionally sialylated and/or fucosylated lactose derivatives of general formula 2 and salts thereof; b) adding at least one enzyme comprising a transglycosidase activity to the at least one compound or a mixture of compounds provided according to step a); and c) incubating the mixture obtained according to step b).
    Type: Application
    Filed: May 23, 2016
    Publication date: October 6, 2016
    Applicant: GLYCOM A/S
    Inventors: Gyula DEKANY, Elise Champion, Markus Hederos
  • Publication number: 20160215315
    Abstract: The application discloses a method for producing an oligosaccharide of at least four monosaccharide units, advantageously an HMO, particularly an HMO of only four monosaccharide units, said method comprising a step of: culturing, in a culture medium containing a fucosylated, sialylated or N-acetyl-glucosaminylated lactose trisaccharide as acceptor, a genetically modified cell having a recombinant gene that encodes an enzyme capable of modifying said acceptor or one of the necessary intermediates in the biosynthetic pathway of the oligosaccharide of at least four monosaccharide units, advantageously an HMO, particularly an HMO of only four monosaccharide units, from said acceptor.
    Type: Application
    Filed: September 5, 2014
    Publication date: July 28, 2016
    Applicant: Glycom A/S
    Inventors: Gyula Dekany, Pauline Peltier-Pain, Dóra Molnár-Gábor, Markus Hederos
  • Publication number: 20160208302
    Abstract: The present application discloses a method of making a mixture of 2?-FL and DFL in high yield by culturing, with lactose, a genetically modified cell having a recombinant gene that encodes a single fucosyl transferase. The resulting mixture of 2?-FL and DFL can be subjected to hydrolysis initiated by an acid or mediated by a fucosidase to produce fucose in high yields.
    Type: Application
    Filed: September 5, 2014
    Publication date: July 21, 2016
    Inventors: Gyula Dekany, Pauline Peltier-Pain, Dóra Molnár-Gábor, Markus Hederos
  • Patent number: 9382564
    Abstract: A method of diversification of human milk oligosaccharides (HMOs) or precursors thereof, compounds obtainable by the method, and uses and compositions involving such compounds. The method comprises a) providing at least one compound or a mixture of the compounds selected from the group consisting of: optionally sialylated and/or fucosylated lactose derivatives of general formula 2 and salts thereof; b) adding at least one enzyme comprising a transglycosidase activity to the at least one compound or a mixture of compounds provided according to step a); and c) incubating the mixture obtained according to step b).
    Type: Grant
    Filed: May 14, 2012
    Date of Patent: July 5, 2016
    Assignee: GLYCOM A/S
    Inventors: Gyula Dekany, Elise Champion, Andreas Schroven, Markus Hederos
  • Publication number: 20160113952
    Abstract: The present application discloses a synthetic mixture of oligosaccharides for treating a microbiota of a mammal, preferably a human, to reduce or eliminate the activity and/or the proportion of a microbe in the microbiota that is associated with the development or maintenance of a disease or an unhealthy condition of the mammal, e.g.
    Type: Application
    Filed: May 22, 2014
    Publication date: April 28, 2016
    Inventor: Gyula Dekany
  • Publication number: 20160075729
    Abstract: An achemo-enzymatic synthesis of oligosaccharides of formula 1 is presented wherein R is selected from —OH, —N3 and —OR6 wherein R6 is selected from allyl optionally substituted by one or more methyl, propargyl optionally substituted by one or more methyl, 2-trimethylsilyl-ethyl, —(CH2)n—NH2 and —(CH2)n—N3 wherein integer n is to 10, preferably 2 or 3, R is selected from sialyl moiety, —SO3H and —CH(R)—COOH wherein R is selected from H, alkyl and benzyl, R2 is selected from H and fucosyl, R3 is selected from H and sialyl, R4 is selected from H and fucosyl, provided that at least one of R3 and R4 is H, and A is a divalent carbohydrate linker, having important biological activities and significant commercial value for the pharmaceutical and food industry.
    Type: Application
    Filed: April 11, 2014
    Publication date: March 17, 2016
    Applicant: GLYCOM A/S
    Inventors: Pierre CHASSAGNE, Nikolay KHANZHIN, Markus HEDEROS, Elise CHAMPION, Martin MATWIEJUK, Gyula DEKANY
  • Publication number: 20160024129
    Abstract: The invention relates to a method for the synthesis of compounds of general formula (1A) and salts thereof wherein one of the R groups is an ?-sialyl moiety and the other is H, X1 represents a carbohydrate linker, A is a D-glucopyranosyl unit optionally substituted with fucosyl, R1 is a protecting group that is removable by hydrogenolysis, the integer in is 0 or 1, by a transsialidation reaction.
    Type: Application
    Filed: July 6, 2015
    Publication date: January 28, 2016
    Applicant: GLYCOM A/S
    Inventors: Andreas SCHROVEN, Elise Champion, Gyula Dekany
  • Patent number: 9237764
    Abstract: The present invention relates to a method for preparation of the trisaccharide 6?-O-sialyllactose (formula (I)) or salts thereof as well as intermediates in the synthesis and for the use of 6?-O-sialyllactose salts in pharmaceutical or nutritional compositions.
    Type: Grant
    Filed: February 21, 2011
    Date of Patent: January 19, 2016
    Assignee: Glycom A/S
    Inventors: Ignacio Figueroa Pérez, Ferenc Horváth, Gyula Dekany, Károly Ágoston, Ágnes Ágoston, István Bajza, Julien Boutet, Markus Hederos, Piroska Kovács-Pénzes, Lars Kröger, Christoph Röhrig, Andreas Schroven, Ioannis Vrasidas, Christian Risinger
  • Patent number: 9234225
    Abstract: A method for generating human milk oligosaccharides (HMOs) or precursors thereof, compounds obtainable by the method, and uses and compositions involving such compounds. The method comprising the steps of a) providing at least one donor selected from the group of compounds of any of formulae 5 to 10, b) providing at least one acceptor from a group of lactose, LNT, LNnT and derivatives thereof, c) providing at least one enzyme comprising a transglycosidase activity and/or a glycosynthase activity, d) preparing a mixture of the at least one donor, at least one acceptor and at least one enzyme provided in steps a), b) and c); and e) incubating the mixture prepared according to step d).
    Type: Grant
    Filed: May 14, 2012
    Date of Patent: January 12, 2016
    Assignee: GLYCOM A/S
    Inventors: Gyula Dekany, Elise Champion, Andreas Schroven, Markus Hederos
  • Publication number: 20150329580
    Abstract: A crystalline LNnT polymorph IV, characterized in that it displays X-ray powder diffraction reflections, based on a measurement using CuK? radiation, at 8.16, 15.41, 39.14, 23.77, 7.77 and 31.15 2? angles, and a crystalline LNnT polymorph V, characterized in that it displays X-ray powder diffraction reflections, based on a measurement using CuK? radiation, at 9.15, 10.26, 19.68, 26.06, 20.61 and 1 1.89 2? angles, are provided.
    Type: Application
    Filed: December 18, 2013
    Publication date: November 19, 2015
    Inventors: Benjámin Podányi, Gyula Dekany
  • Publication number: 20150329579
    Abstract: A method for making an N-substituted D-mannosamine derivative of the following formula 1 and its salts wherein R1 is a non-electron-withdrawing group, and wherein R2 is —OH or R2 is —NHR3 wherein R3 is a group removable by hydrogenolysis; by epimerizing an N-substituted D-glucosamine derivative of the following formula 2 wherein R1 and R2 are as defined above.
    Type: Application
    Filed: December 20, 2013
    Publication date: November 19, 2015
    Applicant: GLYCOM A/S
    Inventors: Ioannis VRASIDAS, Gábor VLÁD, Gyula DEKANY
  • Patent number: 9187513
    Abstract: A compound of the formula (1) wherein R1 is a group removable by hydrogenolysis, and wherein R2 is OH or R2 is —NHR3 wherein R3 is a group removable by hydrogenolysis. The compound can be made from fructose by a Heyns-rearrangement. The compound can be used then to make free D-mannosamine or its salts, D-mannosamine building blocks and mannosamine containing oligo- or polysaccharides, N-acetyl-D-mannosamine and its hydrates and solvates, neuraminic acid derivatives, and viral neuraminidase inhibitors.
    Type: Grant
    Filed: April 11, 2012
    Date of Patent: November 17, 2015
    Assignee: GLYCOM A/S
    Inventors: Ioannis Vrasidas, Gyula Dekany, Ågnes Jánosi, Markus Hederos, Christoph Röhrig
  • Publication number: 20150320780
    Abstract: A method to form a mixture containing at least one of 2?-FL (2?-O-fucosyllactose, Fuc(?1-2)Gal(?1-4)Glc) and 3-FL (3-O-fucosyllactose, Gal(?1-4)[Fuc(?1-3)]Glc) characterized in that DFL (difucosyl-lactose, Fuc(?1-2)Gal(?1-4)[Fuc(?1-3)]Glc) is subjected to partial hydrolysis, e.g. enzymatic hydrolysis or acid hydrolysis.
    Type: Application
    Filed: December 13, 2013
    Publication date: November 12, 2015
    Inventors: Elise Champion, Gyula Dekany, Nikolay Khanzhin, Pierre Chassagne, Györgyi Osztrovszky
  • Publication number: 20150291642
    Abstract: Crystalline 3-O-fucosyllactose, useful in a pharmaceutical composition and a nutritional formulation, is disclosed.
    Type: Application
    Filed: September 19, 2013
    Publication date: October 15, 2015
    Inventors: Martin Matwiejuk, Gyula Dekany
  • Publication number: 20150252400
    Abstract: The invention relates to a method for producing a glycoconjugate comprising an oligosaccharide part covalently linked to a non-sugar moiety selected from the group consisting of amino acids, peptides, proteins, lipids, longer alkyl groups, polyethylene glycols, ?,?-unsaturated amido group and polyvinyl alcohols, using a genetically modified cell.
    Type: Application
    Filed: September 25, 2013
    Publication date: September 10, 2015
    Inventors: Pauline Peltier-Pain, Gyula Dekany, Christophe Pain, Pierre Chassagne, Nicolas Fierfort, Dóra Molnàr-Gàbor
  • Publication number: 20150239923
    Abstract: The present invention relates to the synthesis of the tetrasaccharide of formula (I) and novel intermediates used in the synthesis.
    Type: Application
    Filed: March 2, 2015
    Publication date: August 27, 2015
    Inventors: István Bajza, Gyula Dekany, Károly Ágoston
  • Patent number: 9102966
    Abstract: The invention relates to a method for the synthesis of compounds of general formula (1A) and salts thereof wherein one of the R groups is an ?-sialyl moiety and the other is H, X1 represents a carbohydrate linker, A is a D-glucopyranosyl unit optionally substituted with fucosyl, R1 is a protecting group that is removable by hydrogenolysis, the integer m is 0 or 1, by a transsialidation reaction.
    Type: Grant
    Filed: July 15, 2011
    Date of Patent: August 11, 2015
    Assignee: GLYCOM A/S
    Inventors: Andreas Schroven, Elise Champion, Gyula Dekany, Christoph Röhrig, Ioannis Vrasidas, Ignacio Figueroa Pérez, Markus Hederos, Julien Boutet, Ágnes Ágoston, Piroska Kovács-Pénzes, Ferenc Horváth, Christian Risinger, Gergely Pipa, Sándor Demkó, Lars Kröger
  • Publication number: 20150183814
    Abstract: The present application discloses a method for enhancing the stability of a human milk oligosaccharide (HMO) or a HMO precursor or a HMO blend when stored for extended periods at temperatures above 25° C. by spray-drying an aqueous solution of the HMO or HMO precursor to remove at least 90% of the water and providing a HMO or a HMO precursor or a HMO blend with a specific glass transition temperature. Also disclosed is a method for removing organic solvent residues from a human milk oligosaccharide (HMO) or a HMO precursor or a HMO blend by spray drying. Also disclosed is a method of enhancing the bioavailability of a human milk oligosaccharide (HMO) or a HMO precursor or a HMO blend by spray drying.
    Type: Application
    Filed: June 14, 2013
    Publication date: July 2, 2015
    Applicant: Glycom A/S
    Inventors: Andreas Schroven, Gyula Dekany, Peter Erdmann, Andrea Schwarz