Patents by Inventor Gyula Tircso

Gyula Tircso has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2,11-diaza-[3.3](2,6)pyridinophane compounds and their application as ligands of essential metal ion based MRI contrast agents and 52MN based PET contrast agents
    Patent number: 10968224
    Abstract: The one subject of the invention is the compounds of general formula (I), their isomers, their physiologically acceptable salts and/or Mn(II), Fe(II), Fe(III), Co(II) and Ni(II) complexes. The other subject of the invention is the application of the above compounds.
    Type: Grant
    Filed: November 25, 2016
    Date of Patent: April 6, 2021
    Assignee: DEBRECENI EGYETEM
    Inventors: Richárd Botár, Zoltán Garda, Tamás Fodor, Ferenc Krisztián Kálmán, Viktória Nagy, Gyula Tircsó, Imre Tóth
  • 3,6,9, 15-tetraaza-bicyclo [9.3.1]pentadeca-1(14), 11(15), 12-triene based compounds and their application as ligands of essential metal ion based MRI and 52MN based PET contrast agents
    Patent number: 10894096
    Abstract: A compound of the following general formula (I), and isomers, physiologically acceptable salts, and complexes thereof, for use as a contrast agent in diagnostic imaging:
    Type: Grant
    Filed: January 7, 2020
    Date of Patent: January 19, 2021
    Assignee: DEBRECENI EGYETEM
    Inventors: Richárd Botár, Zoltán Garda, Tamás Fodor, Ferenc Krisztián Kálmán, Viktória Nagy, Gyula Tircsó, Imre Tóth
  • 3,6,9, 15-TETRAAZA-BICYCLO [9.3.1 ]PENTADECA- 1(14), 11(15), 12-TRIENE BASED COMPOUNDS AND THEIR APPLICATION AS LIGANDS OF ESSENTIAL METAL ION BASED MRI AND 52MN BASED PET CONTRAST AGENTS
    Publication number: 20200157099
    Abstract: A compound of the following general formula (I), and isomers, physiologically acceptable salts, and complexes thereof, for use as a contrast agent in diagnostic imaging:
    Type: Application
    Filed: January 7, 2020
    Publication date: May 21, 2020
    Applicant: DEBRECENI EGYETEM
    Inventors: Richárd BOTÁR, Zoltán GARDA, Tamás FODOR, Ferenc Krisztián KÁLMÁN, Viktória NAGY, Gyula TIRCSÓ, Imre TÓTH
  • 3,6,9, 15-tetraaza-bicyclo [9.3.1 ]pentadeca-1(14), 11(15), 12-triene based compounds and their application as ligands of essential metal ion based MRI and 52MN based PET contrast agents
    Patent number: 10568976
    Abstract: A compound of the following general formula (I), and isomers, physiologically acceptable salts, and complexes thereof, for use as a contrast agent in diagnostic imaging:
    Type: Grant
    Filed: November 25, 2016
    Date of Patent: February 25, 2020
    Assignee: DEBRECENI EGYETEM
    Inventors: Richárd Botár, Zoltán Garda, Tamás Fodor, Ferenc Krisztián Kálmán, Viktória Nagy, Gyula Tircsó, Imre Tóth
  • 6-oxa-3,9,15-triaza-bicyclo[9.3.1]pentadeca-1(14),11(15),12-triene derivatives based compounds and their application as ligands of essential metal ion based MRI and MN based PET contrast agents
    Patent number: 10494379
    Abstract: The one subject of the invention is the compounds of general formula (I), their isomers, their physiologically acceptable salts and/or Mn(II), Fe(II), Fe(III), Co(II) and Ni(II) complexes and their application: where R1|=—OH or —NR3R4 amide functionality.
    Type: Grant
    Filed: November 25, 2016
    Date of Patent: December 3, 2019
    Inventors: Richárd Botár, Zoltán Garda, Tamás Fodor, Ferenc Krisztián Kálmán, Viktória Nagy, Gyula Tircsó, Imre Tóth
  • Ethylenediaminetetraacetic acid bis(amide) derivatives and their respective complexes with Mn(II) ion for use as MRI contrast agent
    Patent number: 10265422
    Abstract: The present invention relates to novel substituted ethylenediaminetetraacetic acid bisamide derivatives, their complexes with Mn(II) ion and the use thereof as contrast agents for Magnetic Resonance Imaging (MRI) analysis.
    Type: Grant
    Filed: February 25, 2016
    Date of Patent: April 23, 2019
    Assignee: Bracco Imaging S.P.A.
    Inventors: Zsolt Baranyai, Zoltán Garda, Simona Ghiani, Ferenc Krisztián Kálmán, László Krusper, Alessandro Maiocchi, Gyula Tircsó, Imre Toth
  • NEW 6-OXA-3,9, 15-TRIAZA-BICYCLO[9.3.1 ]PENTADEC A- 1 ( 14), 1 1 ( 15), 12-TRIENE DERIVATIVES BASED COMPOUNDS AND THEIR APPLICATION AS LIGANDS OF ESSENTIAL METAL ION BASED MRI AND 52MN BASED PET CONTRAST AGENTS
    Publication number: 20180354969
    Abstract: The one subject of the invention is the compounds of general formula (I), their isomers, their physiologically acceptable salts and/or Mn(ll), Fe(ll), Fe(lll), Co(ll) and Ni(ll) complexes and their application: where R1|=—OH or —NR3R4 amide functionality
    Type: Application
    Filed: November 25, 2016
    Publication date: December 13, 2018
    Applicant: DEBRECENI EGYETEM
    Inventors: Richárd BOTÁR, Zoltán GARDA, Tamás FODOR, Ferenc Krisztián KÁLMÁN, Viktória NAGY, Gyula TIRCSÓ, Imre TÓTH
  • NEW 3,6,9, 15-TETRAAZA-BICYCLO [9.3.1 ]PENTADECA- 1(14), 11(15), 12-TRIENE BASED COMPOUNDS AND THEIR APPLICATION AS LIGANDS OF ESSENTIAL METAL ION BASED MRI AND 52MN BASED PET CONTRAST AGENTS
    Publication number: 20180344883
    Abstract: The one subject of the invention is the compounds of general formula (I), their isomers, their physiologically acceptable salts and/or Mn(II), Fe(II), Fe(III), Co(II) and Ni(II) complexes. The other subject of the invention is the application of the above compounds.
    Type: Application
    Filed: November 25, 2016
    Publication date: December 6, 2018
    Applicant: DEBRECENI EGYETEM
    Inventors: Richárd BOTÁR, Zoltán GARDA, Tamás FODOR, Ferenc Krisztián KÁLMÁN, Viktória NAGY, Gyula TIRCSÓ, Imre TÓTH
  • NEW 2, 1 L -DIAZA-[3.3](2,6)PYRIDINOPHANE COMPOUNDS AND THEIR APPLICATION AS LIGANDS OF ESSENTIAL METAL ION BASED MRI CONTRAST AGENTS AND 52MN BASED PET CONTRAST AGENTS
    Publication number: 20180282333
    Abstract: The one subject of the invention is the compounds of general formula (I), their isomers, their physiologically acceptable salts and/or Mn(II), Fe(II), Fe(III), Co(II) and Ni(II) complexes. The other subject of the invention is the application of the above compounds.
    Type: Application
    Filed: November 25, 2016
    Publication date: October 4, 2018
    Applicant: DEBRECENI EGYETEM
    Inventors: Richárd BOTÁR, Zoltán GARDA, Tamás FODOR, Ferenc Krisztián KÁLMÁN, Viktória NAGY, Gyula TIRCSÓ, Imre TÓTH
  • ETHYLENEDIAMINETETRAACETIC ACID BIS(AMIDE) DERIVATIVES AND THEIR RESPECTIVE COMPLEXES WITH MN(II) ION FOR USE AS MRI CONTRAST AGENT
    Publication number: 20180036436
    Abstract: The present invention relates to novel substituted ethylenediaminetetraacetic acid bisamide derivatives, their complexes with Mn(II) ion and the use thereof as contrast agents for Magnetic Resonance Imaging (MRI) analysis.
    Type: Application
    Filed: February 25, 2016
    Publication date: February 8, 2018
    Applicant: Bracco Imaging S.p.A.
    Inventors: Zsolt BARANYAI, Zoltán GARDA, Simona GHIANI, Ferenc Krisztián KÁLMÁN, László KRUSPER, Alessandro MAIOCCHI, Gyula TIRCSÓ, Imre TOTH
  • Bifunctional polyazamacrocyclic chelating agents
    Patent number: 8518715
    Abstract: A bifunctional polyazamacrocyclic chelating agent of the formula (I): wherein: and the variables A, L, Q, Q1, X, Y, Z, Z1, m, n and r are as defined in the description of the present application. Also described is a complex of the above chelating agent to an ion of a metal ion, such as an ion of 90Y, 111In or 177Lu; a conjugate of the complex covalently attached to a biological carrier; and a pharmaceutical composition containing the conjugate. A method of therapeutic treatment of a mammal involving administration of the pharmaceutical composition is also described.
    Type: Grant
    Filed: May 21, 2012
    Date of Patent: August 27, 2013
    Assignee: Nordion (Canada) Inc.
    Inventors: Zoltan Kovacs, Garry E. Kiefer, Corinne Bensimon, A. Dean Sherry, Gyula Tircso, Cara Ferreira
  • BIFUNCTIONAL POLYAZAMACROCYCLIC CHELATING AGENTS
    Publication number: 20120276001
    Abstract: A bifunctional polyazamacrocyclic chelating agent of the formula (I): wherein: and the variables A, L, Q, Q1, X, Y, Z, Z1, m, n and r are as defined in the description of the present application. Also described is a complex of the above chelating agent to an ion of a metal ion, such as an ion of 90Y, 111In or 177Lu; a conjugate of the complex covalently attached to a biological carrier; and a pharmaceutical composition containing the conjugate. A method of therapeutic treatment of a mammal involving administration of the pharmaceutical composition is also described.
    Type: Application
    Filed: May 21, 2012
    Publication date: November 1, 2012
    Applicant: Nordion (Canada) Inc
    Inventors: Zoltan Kovacs, Garry E. Kiefer, Corinne Bensimon, A. Dean Sherry, Gyula Tircso, Cara Ferreira
  • Bifunctional polyazamacrocyclic chelating agents
    Patent number: 8198101
    Abstract: A bifunctional polyazamacrocyclic chelating agent of the formula (I): wherein: and the variables A, L, Q, Q1, X, Y, Z, Z1, m, n and r are as defined in the description of the present application. Also described is a complex of the above chelating agent to an ion of a metal ion, such as an ion of 90Y, 111Li or 177Lu; a conjugate of the complex covalently attached to a biological carrier; and a pharmaceutical composition containing the conjugate. A method of therapeutic treatment of a mammal involving administration of the pharmaceutical composition is also described.
    Type: Grant
    Filed: March 6, 2007
    Date of Patent: June 12, 2012
    Assignee: Nordion (Canada) Inc.
    Inventors: Zoltan Kovacs, Garry E. Kiefer, Corinne Bensimon, A. Dean Sherry, Gyula Tircso
  • Bifunctional Polyazamacrocyclic Chelating Agents
    Publication number: 20090202521
    Abstract: A bifunctional polyazamacrocyclic chelating agent of the formula (I): wherein: and the variables A, L, Q, Q1, X, Y, Z, Z1, m, n and r are as defined in the description of the present application. Also described is a complex of the above chelating agent to an ion of a metal ion, such as an ion of 90Y, 111Li or 177Lu; a conjugate of the complex covalently attached to a biological carrier; and a pharmaceutical composition containing the conjugate. A method of therapeutic treatment of a mammal involving administration of the pharmaceutical composition is also described.
    Type: Application
    Filed: March 6, 2007
    Publication date: August 13, 2009
    Applicant: MDS (Canada) Inc.
    Inventors: Zoltan Kovaks, Garry E. Kiefer, Corinne Bensimon, A. Dean Sherry, Gyula Tircso