Patents by Inventor H. A. Daniel Lagassé

H. A. Daniel Lagassé has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Aptamers to von Willebrand factor and their use as thrombotic disease therapeutics
    Patent number: 7998940
    Abstract: The invention relates generally to the field of nucleic acids and more particularly to aptamers capable of binding to von Willebrand Factor useful as therapeutics in and diagnostics of thrombotic diseases and/or other diseases or disorders in which von Willebrand Factor mediated platelet aggregation has been implicated. The invention further relates to materials and methods for the administration of aptamers capable of binding to von Willebrand Factor.
    Type: Grant
    Filed: January 29, 2009
    Date of Patent: August 16, 2011
    Assignee: Archemix Corp.
    Inventors: John L. Diener, H. A. Daniel Lagasse, Claude Benedict
  • Aptamers to von Willebrand Factor and their use as thrombotic disease therapeutics
    Patent number: 7589073
    Abstract: The invention relates generally to the field of nucleic acids and more particularly to aptamers capable of binding to von Willebrand Factor useful as therapeutics in and diagnostics of thrombotic diseases and/or other diseases or disorders in which von Willebrand Factor mediated platelet aggregation has been implicated. The invention further relates to materials and methods for the administration of aptamers capable of binding to von Willebrand Factor.
    Type: Grant
    Filed: January 12, 2006
    Date of Patent: September 15, 2009
    Assignee: Archemix Corp.
    Inventors: John L. Diener, H. A. Daniel Lagassé, Claude Benedict
  • Nucleic acid ligands specific to immunoglobulin E and their use as atopic disease therapeutics
    Patent number: 7579450
    Abstract: The invention discloses aptamers capable of binding to Immunoglobulin E (“IgE”) useful as therapeutics in and diagnostics of atopic disease and/or other diseases or disorders in which IgE has been implicated. The invention further relates to materials and methods for the administration of aptamers capable of binding to IgE.
    Type: Grant
    Filed: April 26, 2005
    Date of Patent: August 25, 2009
    Assignee: Archemix Corp.
    Inventors: Paula Burmeister, Sharon Cload, John L. Diener, Anthony Dominic Keefe, Sara Chesworth Keene, Markus Kurz, H. A. Daniel Lagassé, Harold Nicholas Marsh, Pooja Sawhney, Chunhua Wang
  • Aptamers to von Willebrand Factor and their use as thrombotic disease therapeutics
    Patent number: 7566701
    Abstract: The invention relates generally to the field of nucleic acids and more particularly to aptamers capable of binding to von Willebrand Factor useful as therapeutics in and diagnostics of thrombotic diseases and/or other diseases or disorders in which von Willebrand Factor mediated platelet aggregation has been implicated. The invention further relates to materials and methods for the administration of aptamers capable of binding to von Willebrand Factor.
    Type: Grant
    Filed: September 7, 2005
    Date of Patent: July 28, 2009
    Assignee: Archemix Corp.
    Inventors: John L. Diener, H. A. Daniel Lagassé, Claude Benedict
  • Aptamers to von Willebrand factor and their use as thrombotic disease therapeutics
    Publication number: 20090149643
    Abstract: The invention relates generally to the field of nucleic acids and more particularly to aptamers capable of binding to von Willebrand Factor useful as therapeutics in and diagnostics of thrombotic diseases and/or other diseases or disorders in which von Willebrand Factor mediated platelet aggregation has been implicated. The invention further relates to materials and methods for the administration of aptamers capable of binding to von Willebrand Factor.
    Type: Application
    Filed: January 29, 2009
    Publication date: June 11, 2009
    Applicant: Archemix Corp.
    Inventors: John L. Diener, H.A. Daniel Lagasse, Claude Benedict
  • Aptamers to the human IL-12 cytokine family and their use as autoimmune disease therapeutics
    Publication number: 20090082555
    Abstract: The present invention provides materials and methods to treat immune disease in which cytokines are involved in pathogenesis. The materials and methods of the present invention are useful in the treatment of autoimmune diseases. The materials and methods of the present invention are directed to nucleic acid ligands capable of binding to human IL-23 and/or human IL-12 cytokines and thus modulate their biological activity and are useful as therapeutic agents in immune, auto-immune and cancer therapeutics.
    Type: Application
    Filed: June 9, 2008
    Publication date: March 26, 2009
    Inventors: John L. Diener, Alicia Ferguson, Nobuko Hamaguchi, Sara Chesworth Keene, H.A. Daniel Lagasse, Pooja Sawhney, Kristin Thompson