Patents by Inventor H.A. Lagasse

H.A. Lagasse has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Aptamers to the human IL-12 cytokine family and their use as autoimmune disease therapeutics
    Publication number: 20070066550
    Abstract: The present invention provides materials and methods to treat immune disease in which cytokines are involved in pathogenesis. The materials and methods of the present invention are useful in the treatment of autoimmune diseases. The materials and methods of the present invention are directed to nucleic acid ligands capable of binding to human IL-23 and/or human IL-12 cytokines and thus modulate their biological activity and are useful as therapeutic agents in immune, auto-immune and cancer therapeutics.
    Type: Application
    Filed: March 7, 2005
    Publication date: March 22, 2007
    Inventors: John Diener, Alicia Ferguson, Nobuko Hamaguchi, Sara Keene, H.A. Lagasse, Pooja Sawhney, Kristin Thompson
  • Nucleic acid ligands specific to immunoglobulin E and their use as atopic disease therapeutics
    Publication number: 20070009907
    Abstract: The invention discloses aptamers capable of binding to Immunoglobulin E (“IgE”) useful as therapeutics in and diagnostics of atopic disease and/or other diseases or disorders in which IgE has been implicated. The invention further relates to materials and methods for the administration of aptamers capable of binding to IgE.
    Type: Application
    Filed: April 26, 2005
    Publication date: January 11, 2007
    Inventors: Paula Burmeister, Sharon Cload, John Diener, Anthony Keefe, Sara Keene, Markus Kurz, H.A. Lagasse, Harold Marsh, Pooja Sawhney, Chunhua Wang
  • Aptamers to von Willebrand Factor and their use as thrombotic disease therapeutics
    Publication number: 20060264369
    Abstract: The invention relates generally to the field of nucleic acids and more particularly to aptamers capable of binding to von Willebrand Factor useful as therapeutics in and diagnostics of thrombotic diseases and/or other diseases or disorders in which von Willebrand Factor mediated platelet aggregation has been implicated. The invention further relates to materials and methods for the administration of aptamers capable of binding to von Willebrand Factor.
    Type: Application
    Filed: January 12, 2006
    Publication date: November 23, 2006
    Inventors: John Diener, H.A. Lagasse, Claude Benedict
  • Aptamers to the human IL-12 cytokine family and their use as autoimmune disease therapeutics
    Publication number: 20060193821
    Abstract: The present invention provides materials and methods to treat immune disease in which cytokines are involved in pathogenesis. The materials and methods of the present invention are useful in the treatment of autoimmune diseases. The materials and methods of the present invention are directed to nucleic acid ligands capable of binding to human IL-23 and/or human IL-12 cytokines and thus modulate their biological activity and are useful as therapeutic agents in immune, auto-immune and cancer therapeutics.
    Type: Application
    Filed: September 22, 2005
    Publication date: August 31, 2006
    Inventors: John Diener, David Epstein, Alicia Ferguson, Nobuko Hamaguchi, H.A. Lagasse, Shannon Pendergrast, Pooja Sawhney, Kristin Thompson
  • Aptamers to von Willebrand factor and their use as thrombotic disease therapeutics
    Publication number: 20060183702
    Abstract: The invention relates generally to the field of nucleic acids and more particularly to aptamers capable of binding to von Willebrand Factor useful as therapeutics in and diagnostics of thrombotic diseases and/or other diseases or disorders in which von Willebrand Factor mediated platelet aggregation has been implicated. The invention further relates to materials and methods for the administration of aptamers capable of binding to von Willebrand Factor.
    Type: Application
    Filed: September 7, 2005
    Publication date: August 17, 2006
    Inventors: John Diener, H.A. Lagasse, Claude Benedict
  • Process for forming curved hollow elements and an apparatus for carrying out this process
    Patent number: 4205546
    Abstract: A method and apparatus of forming curved hollow elements by drawing comprising providing a die having an inlet opening, providing a punch which is mounted for rotation at a center of rotation which is in the plane of the inlet opening with the punch having a shape of a section of an annulus with a center of the annulus corresponding to the center of rotation of the punch, placing a blank over the inlet opening of the die and driving the punch into the inlet opening to shape the blank into a curved hollow element. The blank is held over the die inlet opening by a blank holder and hydraulic or pneumatic jacks are connected to the die and/or punch for moving them with respect to each other to form the curved hollow elements.
    Type: Grant
    Filed: June 9, 1978
    Date of Patent: June 3, 1980
    Assignee: Spiro Investment S.A.
    Inventors: Paul-Emile H. Lagasse, Ferenc J. Virag