Abstract: For analyzing a sample containing particles of at least two categories, such as a sample containing blood cells, a particle counter subject to a detection limit is coupled with an analyzer capable of discerning particle number ratios, such as a visual analyzer, and a processor. A first category of particles can be present beyond detection range limits while a second category of particles is present within respective detection range limits. The concentration of the second category of particles is determined by the particle counter. A ratio of counts of the first category to the second category is determined on the analyzer. The concentration of particles in the first category is calculated on the processor based on the ratio and the count or concentration of particles in the second category.

Abstract: An apparatus has a plurality of gas transfer membranes. The apparatus floats in water with the membranes submerged in the water. To treat the water, a gas is supplied to the membranes and is transferred to a biofilm supported on the membranes or to the water. Gas is also used to supply mixing or membrane scouring bubbles to the water. The mixing or scouring bubbles can be provided by a cyclic aeration or other gas supply system, which optionally provides gas at a variable pressure to the membranes in parallel or series with an aerator. Condensates can be removed from the membranes, and exhaust gasses from the membranes can be monitored, optionally through one or more dedicated pipes.

Abstract: An annuloplasty band and method of implantation. The band is shaped and sized to avoid the adjacent aortic valve structure and better protects against dehiscence along the muscular mitral annulus. The band is asymmetric and when implanted spans more around the side of the mitral annulus having the posterior commissure than the side with the anterior commissure. The band has a saddle shape with a posterior upward bow centered on a minor axis of the mitral annulus, and a span extending clockwise therefrom is longer than a span extending counter-clockwise. A set of rings may have different saddle profiles and different plan view shapes for different sized bands. A method includes implanting so that the band extends over the posterior leaflet and a short distance past the posterior commissure outside of the anterior leaflet.

Abstract: A golf club shaft system and golf club shaft possessing unique characteristics including flexural and torsional rigidity profiles.

Abstract: A device for controlling thrust vectoring of a cyclorotor includes a control cam positionable relative to a drive shaft of a cyclorotor along each of a first axis and a second axis, where the drive shaft is rotatable about a third axis. The device may further include a frame having a plurality of sides, where the frame is disposed at least partly around the drive shaft of the cyclorotor, a first positioning assembly disposed on a first side of the frame, where the first positioning assembly is structurally configured to move the frame along the first axis, and a second positioning assembly disposed on a second side of the frame, where the second positioning assembly is engaged with the control cam and structurally configured to move the control cam relative to the frame along the second axis.

Abstract: Portable water conditioning systems include a water conditioner having a plurality of conditioning stages including, in a direction of flow of the water through the water conditioner, a reverse osmosis stage having a reverse osmosis membrane, and a deionizing stage. A first sensor is configured to detect a first condition of the water before the reverse osmosis stage and a second sensor configured to detect a second condition of the water after the reverse osmosis stage. The conditions each include (i) a level of total dissolved solids of the water and (ii) temperature of the water. A controller is in communication with the sensors and configured to determine of a percent of dissolved solids that are rejected by the reverse osmosis membrane based on the conditions when backpressure on the reverse osmosis stage is at a known state.

Abstract: Described herein are compositions and methods to cryopreserve sporozoites. In some aspects, the method can include the step of placing harvested salivary glands containing sporozoites into an insect-based medium.

Abstract: Described herein are compounds, formulations, and methods for blocking sporozoite invasion and subsequent liver-stage parasite development of a protozoan parasite, such as Plasmodium falciparum.

Abstract: An apparatus or system can act as a cooling device configured for cooling a plurality of high-power electronic components mounted on a circuit board. The apparatus includes a plurality of cooling plate assemblies, the cooling plate assemblies each including a cooling plate for mating to one of the high-power electronic components and an enclosure mounted to the cooling plate for defining a coolant transport path over at least part of a surface thereof. The apparatus further includes one or more flexible conduits that connect between the cooling plate assemblies for fluid communication between their respective coolant transport paths.

Abstract: A portable water conditioning system is provided that includes a water conditioner, a first sensor, a second sensor, and a controller. The water conditioner has a plurality of conditioning stages that condition water. The plurality of conditioning stages include, in a direction of flow of the water through the water conditioner, a reverse osmosis stage and a deionizing stage. The first sensor detects a first condition of the water before the reverse osmosis stage. The second sensor detects a second condition of the water after the reverse osmosis stage. The controller is in communication with the first and second sensors and determines a health status of the reverse osmosis stage based the first and second conditions. The first and second conditions each include a level of total dissolved solids of the water.

Abstract: Provided is a method comprising recommending treatment of a prostate cancer patient with a polo-like kinase-1 (PLK1) inhibitor if the patient has rising prostate specific antigen (PSA) levels. Also provided is a method comprising measuring prostate specific antigen (PSA) levels in at least two samples from a prostate cancer patient, the samples obtained from the patient at different times; and recommending treatment of the patient with a PLK1 inhibitor if the PSA levels in the samples increase over time, or not recommending treatment of the patient with a PLK1 inhibitor if the PSA levels in the samples do not increase over time. Additionally provided is a method comprising recommending treatment of a PLK1 inhibitor to a patient having a prostate cancer that has an altered androgen receptor that does not require ligand for activation.

Abstract: A golf club shaft system and golf club shaft possessing unique flexural and torsional rigidity profiles, while providing significant adjustability to fine tune the shaft to a particular golf swing.

Abstract: A conventional media filter such as a gravity sand filter is converted into a membrane filter. The media is removed and replaced by immersed membrane modules. Transmembrane pressure is created by a static head pressure differential, without a suction pump, thereby creating a membrane gravity filter (MGF). Preferred operating parameters include transmembrane pressure of 5-20 kPa, 1-3 backwashes per day, and a flux of 10-20 L/m2/h. The membranes are dosed with chlorine or another oxidant, preferably at 700 minutes*mg/L as Cl2 equivalent per week or less. The small oxidant does is believed to provide a porous biofilm or fouling layer without substantially removing the layer. The media filter may be modified so that backwash wastewater is removed from near the bottom of the tank rather than through backwash troughs above the membrane modules. Membrane integrity testing may be done while the tank is emptied after a backwash.

Abstract: Described herein are compounds, formulations, and methods for blocking sporozoite invasion and subsequent liver-stage parasite development of a protozoan parasite, such as Plasmodium falciparum.

Abstract: Described herein are compositions and methods to cryopreserve sporozoites. In some aspects, the method can include the step of placing harvested salivary glands containing sporozoites into an insect-based medium.

Abstract: Provided is a method of treating benign prostatic hyperplasia (BPH) in a patient. Also provided is a method of inhibiting non-adrenergic contraction of a smooth muscle. Additionally provided is a method of inhibiting proliferation of human prostate cells.

Abstract: An annuloplasty band and method of implantation. The band is shaped and sized to avoid the adjacent aortic valve structure and better protects against dehiscence along the muscular mitral annulus. The band is asymmetric and when implanted spans more around the side of the mitral annulus having the posterior commissure than the side with the anterior commissure. The band has a saddle shape with a posterior upward bow centered on a minor axis of the mitral annulus, and a span extending clockwise therefrom is longer than a span extending counter-clockwise. The longer span may be 150° while the shorter span extends 90°. A set of rings may have different saddle profiles and different plan view shapes for different sized bands. A method includes implanting so that the band extends over the posterior leaflet and a short distance past the posterior commissure outside of the anterior leaflet.

Abstract: A time transfer modem includes a radio frequency integrated circuit (RFIC), a radio frequency (RF) front end, and processing circuitry. The RF front end is configured to receive and up-convert an input for time transfer with a remote station to generate an up-converted timing signal centered at a select frequency that is outside of a frequency range of interest but within an operational frequency range of the RFIC. The RF front end may also be configured to attenuate, via a pre-selection filter, up-converted adjacent signals to generate a filtered timing signal at the select frequency. The RFIC may be configured to down-convert and digitize the filtered timing signal to generate a digitized timing signal for signal processing by the processing circuitry to determine a clock difference between a local clock signal and the digitized timing signal that originated from the remote station.

Abstract: A time transfer modem includes a radio frequency integrated circuit (RFIC), a radio frequency (RF) front end, and processing circuitry. The RF front end is configured to receive and up-convert an input for time transfer with a remote station to generate an up-converted timing signal centered at a select frequency that is outside of a frequency range of interest but within an operational frequency range of the RFIC. The RF front end may also be configured to attenuate, via a pre-selection filter, up-converted adjacent signals to generate a filtered timing signal at the select frequency. The RFIC may be configured to down-convert and digitize the filtered timing signal to generate a digitized timing signal for signal processing by the processing circuitry to determine a clock difference between a local clock signal and the digitized timing signal that originated from the remote station.

Abstract: A large haul box for use in a pickup or trailer is disclosed. The large haul box includes a pair of long side wall having a top side, a bottom side, an open end and a back end, a back wall coupled between the back ends of the pair of long side walls, a bottom surface coupled to the back wall along a short end and coupled to the pair of long side walls on their bottom sides, a bottom sheathing coupled to the bottom surface, a long side sheathing coupled to each of the pair of long side walls, a back sheathing coupled to the back wall, and a removable box end having a top side, a bottom side, and a pair of short sides between the top and bottom sides for coupling to the open ends of the pair of long side walls along the pair of short sides and oriented to have the bottom side of the removable box end couple to the open end of the bottom surface.