Patents by Inventor H. Alan Wood

H. Alan Wood has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Sialylation of N-linked glycoproteins in the baculovirus expression vector system
    Patent number: 6472175
    Abstract: The present disclosure utilizes a novel approach to protein preparation in the baculovirus expression vector system (BEVS). Specifically, the present invention analyzes the effects of supplementing insect cell culture media with dexamethasone or N-acetylmannosarnine on complex glycosylation of proteins prepared via BEVS, including the addition of terminal sialic acid residues to N-linked oligosaccharides.
    Type: Grant
    Filed: November 17, 2000
    Date of Patent: October 29, 2002
    Assignee: Boyce Thompson Institute For Plant Research, Inc.
    Inventor: H. Alan Wood
  • Sialyiation of N-linked glycoproteins in the baculovirus expression vector system
    Patent number: 6261805
    Abstract: The present disclosure utilizes a novel approach to protein preparation in the baculovirus expression vector system (BEVS). Specifically, the present invention analyzes the effects of microgravity/low shear on complex glycosylation of proteins prepared via BEVS, including the addition of terminal sialic acid residues to N-linked oligosaccharides.
    Type: Grant
    Filed: July 15, 1999
    Date of Patent: July 17, 2001
    Assignee: Boyce Thompson Institute for Plant Research, Inc.
    Inventor: H. Alan Wood
  • Stable pre-occluded virus particle for use in recombinant protein production and pesticides
    Patent number: 6090379
    Abstract: A method of infecting insects is disclosed; the method utilizes a form of a baculovirus which is highly efficient at establishing infection and is normally destined to become occluded within the polyhedrin or granulin--Pre-occluded Virus (POV). Specifically, the POV as derived from a polyhedrin-minus or granulin-minus (lacking a functional polyhedrin or granulin gene) baculovirus is fed to insect larvae per os resulting in high infection rates. The stabilization and use of the POV form of polyhedrin-minus baculoviruses for recombinant protein production and as an insecticide is also disclosed.
    Type: Grant
    Filed: March 23, 1998
    Date of Patent: July 18, 2000
    Assignee: Boyce Thompson Institute for Plant Research, Inc.
    Inventor: H. Alan Wood
  • Stable pre-occluded virus particle
    Patent number: 5593669
    Abstract: A method of infecting insects is disclosed; the method utilizes a form of a baculovirus which is highly efficient at establishing infection and is normally destined to become occluded within the polyhedrin or granulin--Pre-occluded Virus (POV). Specifically, the POV as derived from a polyhedrin-minus or granulin-minus (lacking a functional polyhedrin or granulin gene) baculovirus is fed to insect larvae per os resulting in high infection rates. The stabilization and use of the POV form of polyhedrin-minus baculoviruses as an insecticide is also disclosed.
    Type: Grant
    Filed: August 25, 1994
    Date of Patent: January 14, 1997
    Assignee: Boyce Thompson Institute for Plant Research, Inc.
    Inventor: H. Alan Wood