Abstract: The disclosure is directed to the synthesis and improved methods for purifying macrocyclic peptides produced by solid phase peptide synthesis. The synthesized peptide is capped with an alkyne-functionalized or azide-functionalized compound of formula (I): prior to cleavage of the peptide from the solid phase support.

Abstract: The disclosure is directed to the synthesis and improved methods for purifying macrocyclic peptides produced by solid phase peptide synthesis.

Abstract: An additive manufacturing apparatus includes a laser and a detection system. The laser emits a laser beam to heat a powder bed to form a melt pool, and the melt pool emits light proportional to a temperature of the melt pool. The detection system includes a spectral disperser and one of a) two or more on-axis sensors or b) a line scanner. The two or more on-axis sensors or the line scanner are/is located along an axis of the emitted light, the detection system receives the emitted light from the melt pool, and an intensity of the emitted light detected by the a) two or more on-axis sensors or the b) line scanner is compared with a blackbody spectral map at a particular wavelength of the emitted light to determine a temperature of the melt pool.

Abstract: The disclosure is directed to compounds and methods for preparing purified macrocyclic peptide using “catch-release” methods. These methods comprise reacting a free amino group of a resin-bound linear peptide with an azide- or alkyne-functionalized cap to form a resin-bound capped linear peptide having an azide- or alkyne-functionalized cap; cleaving the capped linear peptide from the resin to form a free capped linear peptide having an azide- or alkyne-functionalized cap; reacting the free capped linear peptide having an azide-functionalized cap with an alkyne-functionalized catch resin, or reacting the free capped linear peptide having an akynyl-functionalized cap with an azide functionalized catch resin, to form a catch-resin bound capped linear peptide; reacting the catch-resin bound capped linear peptide under conditions sufficient to effect macrocyclization of the linear peptide and release of the macrocyclic peptide from the catch resin.

Abstract: A method for monitoring and analyzing an additive manufacturing process includes heating a melt zone to fuse an additive media with an active layer to build a part being manufactured based on a part design model, capturing raw melt data of the melt zone, and generating an active layer dataset that is spatially defined. The method may also include analyzing the active layer dataset with respect to a plurality of defect signatures within a defect signature library. The defect signature library may be predefined based on a machine learning processing of historical sensor datasets with corresponding ground truth datasets. The method may also include detecting a defect in the part based on the analysis of the active layer dataset with respect to a plurality of defect signatures, simultaneously with the energy source acting upon the active layer of the part for manufacturing of the part.

Abstract: The disclosure is directed to compounds and methods for preparing purified macrocyclic peptide using “catch-release” methods. These methods comprise reacting a free amino group of a resin-bound linear peptide with an azide- or alkyne-functionalized cap to form a resin-bound capped linear peptide having an azide- or alkyne-functionalized cap; cleaving said capped linear peptide from the resin to form a free capped linear peptide having an azide- or alkyne-functionalized cap; reacting the free capped linear peptide having an azide-functionalized cap with an alkyne-functionalized catch resin, or reacting the free capped linear peptide having an akynyl-functionalized cap with an azide functionalized catch resin, to form a catch-resin bound capped linear peptide; reacting the catch-resin bound capped linear peptide under conditions sufficient to effect macrocyclization of the linear peptide and release of the macrocyclic peptide from the catch resin.

Abstract: Measurements or models of a human body are generated. An image of the human body may be identified and a fiducial map may be generated. The fiducial map may be compared to pre-processed fiducial maps stored in a data store. A plurality of pre-processed fiducial maps of human bodies may be identified when a correlation between the fiducial map and the pre-processed fiducial maps exceeds a defined threshold. A silhouette image of the human body may be generated based on the image and may be compared to pre-processed silhouette images associated with the plurality of pre-processed fiducial maps. One of the pre-processed silhouette images may be identified when a correlation value between the silhouette image and the pre-processed silhouette images exceeds a defined threshold. Measurements or a model of the human body may be identified based on the one of the pre-processed silhouette images.

Abstract: Compositions include an aqueous solution of an organic dye of molecular weight in the range of about 300 to about 1,000 and a density-enhancing material. An amount of the density-enhancing material in the aqueous solution is sufficient to achieve a density of about 1.0 to about 1.3 g/mL. The composition has a viscosity of about 3.5 to about 5.0 centipoise. The compositions are useful in assessing the adequacy of a liquid handling mixing device to mix a reaction mixture.

Abstract: The present technology is directed to system and method capture and process body measurement data including body scanners including stationary cameras disposed about a tower and a rotatable platform disposed at a distance away from the cameras. The body scanner is configured to capture a first and second pluralities of depth images of a user standing atop the rotatable platform at first and second capture times, create three dimensional avatars of the user associated respectively with the first and second capture times, and extract body measurement data of the user associated respectively with the first and second capture times. A user interface is configured to retrieve and display and compare the body measurement data and three dimensional avatar of the first and second capture times.

Abstract: Tools are provided to assist users of cloud computing systems to create, monitor, and debug the resource instances they need. Specifically, resource instances are created in a cloud computing system based on a blueprint that is provided to a blueprint processor. The blueprint declaratively defines the resources that the user needs to have created in the cloud. Based on the information contained in blueprint, the blueprint processor causes the cloud to orchestrate the creation of resource instances, doing so in parallel when possible, and to configure those resource instances as specified in blueprint. Techniques are described for generating a timeline to convey status during the deployment process, and for performing debugging operations.

Abstract: Measurements or models of a human body are generated. An image of the human body may be identified and a fiducial map may be generated. The fiducial map may be compared to pre-processed fiducial maps stored in a data store. A plurality of pre-processed fiducial maps of human bodies may be identified when a correlation between the fiducial map and the pre-processed fiducial maps exceeds a defined threshold. A silhouette image of the human body may be generated based on the image and may be compared to pre-processed silhouette images associated with the plurality of pre-processed fiducial maps. One of the pre-processed silhouette images may be identified when a correlation value between the silhouette image and the pre-processed silhouette images exceeds a defined threshold. Measurements or a model of the human body may be identified based on the one of the pre-processed silhouette images.

Abstract: A method and apparatus for distinguishing voice signals that are played together over the same speaker employs spectral reshaping of one or more of the audio signals. The spectral reshaping shifts modifies the timber of the voice signal while not modifying the pitch of the voice signal. Additional techniques can be used to further distinguish voice signals, such as dynamic gain offset and frequency shifting. After processing one or more signals to spectrally reshape them, they can be played over the same speaker. A user hearing the resulting acoustic signal will be more able to distinguish between the multiple voice signals being played.

Abstract: The present invention is directed to system and method capture and process body measurement data including one or more body scanners, each body scanner configured to capture a plurality depth images of a user. A backend system, coupled to each body scanner, is configured to receive the plurality of depth images, generate a three dimensional avatar of the user based on the plurality of depth images, and generate a set of body measurements of the user based on the avatar. A repository is in communication with the backend system and configured to associate the body scanner data with the user and store the body scanner data.

Abstract: Compositions include an aqueous solution of an organic dye of molecular weight in the range of about 300 to about 1,000 and a density-enhancing material. An amount of the density-enhancing material in the aqueous solution is sufficient to achieve a density of about 1.0 to about 1.3 g/mL. The composition has a viscosity of about 3.5 to about 5.0 centipoise. The compositions are useful in assessing the adequacy of a liquid handling mixing device to mix a reaction mixture.

Abstract: The agile information technology infrastructure management system and related methods and processes provide a solution with the required flexibility to effectively and efficiently monitor and manage a wide-variety of disparate information technology and network infrastructure deployed in businesses and enterprises throughout a region or the world.

Abstract: Tools are provided to assist users of cloud computing systems to create, monitor, and debug the resource instances they need. Specifically, resource instances are created in a cloud computing system based on a blueprint that is provided to a blueprint processor. The blueprint declaratively defines the resources that the user needs to have created in the cloud. Based on the information contained in blueprint, the blueprint processor causes the cloud to orchestrate the creation of resource instances, doing so in parallel when possible, and to configure those resource instances as specified in blueprint. Techniques are described for generating a timeline to convey status during the deployment process, and for performing debugging operations.

Abstract: Tools are provided to assist users of cloud computing systems to create, monitor, and debug the resource instances they need. Specifically, resource instances are created in a cloud computing system based on a blueprint that is provided to a blueprint processor. The blueprint declaratively defines the resources that the user needs to have created in the cloud. Based on the information contained in blueprint, the blueprint processor causes the cloud to orchestrate the creation of resource instances, doing so in parallel when possible, and to configure those resource instances as specified in blueprint. Techniques are described for generating a timeline to convey status during the deployment process, and for performing debugging operations.

Abstract: A method and apparatus for distinguishing voice signals that are played together over the same speaker employs spectral reshaping of one or more of the audio signals. The spectral reshaping shifts modifies the timber of the voice signal while not modifying the pitch of the voice signal. Additional techniques can be used to further distinguish voice signals, such as dynamic gain offset and frequency shifting. After processing one or more signals to spectrally reshape them, they can be played over the same speaker. A user hearing the resulting acoustic signal will be more able to distinguish between the multiple voice signals being played.

Abstract: The present invention is directed to system and method capture and process body measurement data including one or more body scanners, each body scanner configured to capture a plurality depth images of a user. A backend system, coupled to each body scanner, is configured to receive the plurality of depth images, generate a three dimensional avatar of the user based on the plurality of depth images, and generate a set of body measurements of the user based on the avatar. A repository is in communication with the backend system and configured to associate the body scanner data with the user and store the body scanner data.

Abstract: The present invention is directed to system and method capture and process body measurement data including one or more body scanners, each body scanner configured to capture a plurality depth images of a user. A backend system, coupled to each body scanner, is configured to receive the plurality of depth images, generate a three dimensional avatar of the user based on the plurality of depth images, and generate a set of body measurements of the user based on the avatar. A repository is in communication with the backend system and configured to associate the body scanner data with the user and store the body scanner data.