Abstract: Methods of treating subjects having a HER2-expressing cancer with an anti-HER2 biparatopic antibody using a 2-tiered fixed dosing regimen based on the weight of subjects being treated are described. Combination therapy with chemotherapeutic agents and/or a PD-1 inhibitor, for example an anti-PD-1 antibody, are also described.

Abstract: The invention relates to compounds or pharmaceutically acceptable salts thereof, compositions containing them, including combinations with at least one additional therapeutic agent, and their use in therapy, for example in the treatment of mycobacterial infections or in the treatment of diseases caused by a mycobacterium, such as tuberculosis.

Abstract: A funerary method includes disposing a deceased adult human body in supine position on an insert having side walls and end walls. The method further includes providing the insert on a tray having two end panels and a plurality of side panels affixed to a bottom panel, and inserting a first edge of a first fabric segment between a side panel of the tray and a side wall of the insert. The first fabric segment is used to cover at least a portion of a top edge of at least the first side wall of the insert and at least a portion of the deceased human body, such that the deceased human body is sufficiently visible for identification. Thereafter, the insert and the deceased human body are removed from the tray.

Abstract: A shipment package includes container blanks and lid blanks. Each container blank has a first length and is foldable into a casket container. Each container blank has first and second folded over ends. The container blanks are stacked such that the first folded over ends of the plurality of container blanks are at least partially aligned, and such that the second folded over ends of the plurality of container blanks are at least partially aligned. Each lid blank is foldable into a casket lid having at least approximately the first length, and is configured to cover an interior of the casket container. Each lid blank is folded over a widthwise fold line such that the lid blank has a length less than the first length. A first lid blank is disposed between two container blanks, and between folded over ends of one of the container blanks.

Abstract: The present invention relates to fibronectin based scaffold domain proteins that bind PCSK9. The invention also relates to the use of the innovative proteins in therapeutic applications to treat atherosclerosis, hypercholesterolemia and other cholesterol related diseases. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative protein.

Abstract: A shipment package includes container blanks and lid blanks. Each container blank has a first length and is foldable into a casket container. Each container blank has first and second folded over ends. The container blanks are stacked such that the first folded over ends of the plurality of container blanks are at least partially aligned, and such that the second folded over ends of the plurality of container blanks are at least partially aligned. Each lid blank is foldable into a casket lid having at least approximately the first length, and is configured to cover an interior of the casket container. Each lid blank is folded over a widthwise fold line such that the lid blank has a length less than the first length. A first lid blank is disposed between two container blanks, and between folded over ends of one of the container blanks.

Abstract: A casket lid includes a lid body that extends partially over a casket body configured to receive a human body in supine position, the lid body having a first side configured to extend along a portion of a first casket body side, a second side configured to extend along a portion of a second casket body side, a first end configured to extend along a first casket body end, and an open end. A skirt assembly includes a substrate having a top edge, and further includes at least one sheet of flexible material affixed to and extending over the top edge and downward from the substrate. The sheet of flexible material extends to or below a vertical level of a lowest portion of at least one of the first side and the second side.

Abstract: A funerary method includes disposing a deceased adult human body in supine position on an insert having side walls and end walls. The method further includes providing the insert on a tray having two end panels and a plurality of side panels affixed to a bottom panel, and inserting a first edge of a first fabric segment between a side panel of the tray and a side wall of the insert. The first fabric segment is used to cover at least a portion of a top edge of at least the first side wall of the insert and at least a portion of the deceased human body, such that the deceased human body is sufficiently visible for identification. Thereafter, the insert and the deceased human body are removed from the tray.

Abstract: The present invention relates to fibronectin based scaffold domain proteins that bind PCSK9. The invention also relates to the use of the innovative proteins in therapeutic applications to treat atherosclerosis, hypercholesterolemia and other cholesterol related diseases. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative protein.

Abstract: Disclosed is a concrete screed device, having: a handle structure defining a lower end and an upper end spaced apart from each other to define a screed handle structure height; a base bar connected to the lower end of the handle structure; an screed bar disposed against the base bar and configured to oscillate against the base bar; and a motor supported by the screed and operationally connected to the screed bar to oscillate within an oscillatory range of movement against the base bar.

Abstract: A concrete screed device, having: a base bar extending between first and second ends and having a bottom member and an upright member; a handle structure connected to the base bar, between the first and second ends, and extending away from the base bar to a grip portion; a screed bar disposed against the upright member of the base bar; guide members connected to the screed bar and extending through the upright member of the base bar; a battery powered motor supported along the base bar and operationally connected to one of the guide members to oscillate the screed bar against the base bar; and a wheel supported under the bottom member of the base bar near the first end of the base bar.

Abstract: The present disclosure is directed to designing dyes and methods to alter the parameters controlling the dipole-dipole coupling of dyes bound to a nucleotide oligomer architecture, which are used to propagate excitons for use in next generation room temperature quantum information systems. The disclosed dyes and methods are directed to changing the dye stability, symmetry, overlap, and steric hindrance of the dyes to fine tune aggregate systems.

Abstract: A casket lid includes a lid body and a bridge formed from a folded corrugated paper blank. The lid body extends partially over a casket body configured to receive a human body in supine position, the lid body having a first side configured to extend along a portion of a first casket body side, a second side configured to extend along a portion of a second casket body side, a first end configured to extend along a first casket body end, and an open end. Edges of at least two of the first side, second side, and first end define a lid body bottom plane. The bridge extends downward from the lid body near or at the open end, and defines a concave opening extending above the lid body bottom plane.