Patents by Inventor H. Fred Clark

H. Fred Clark has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Rotavirus reassortant vaccine
    Patent number: 6290968
    Abstract: The present invention provides novel rotavirus reassortants, vaccines employing the novel reassortants and methods for their preparation and administration. One such reassortant contains the gene encoding the v.p.7 neutralization antigen of a human rotavirus. Another reassortant contains the gene encoding the v.p.4 neutralization antigen of a human rotavirus. The remaining genes are provided solely from the bovine rotavirus WC3 strain, or from both the human and bovine strains.
    Type: Grant
    Filed: July 28, 2000
    Date of Patent: September 18, 2001
    Assignees: Children's Hospital of Philadelphia, Wistar Institute of Anatomy and Biology
    Inventors: H Fred Clark, Paul Offit, Stanley A. Plotkin
  • Aqueous solvent based encapsulation of a bovine herpes virus type-1 subunit vaccine
    Patent number: 6270800
    Abstract: A microencapsulated subunit component from bovine herpes virus-1 (BHV-1) is disclosed. Vaccines, kits, and methods for using the same to vaccinate a member of a bovine species are also disclosed.
    Type: Grant
    Filed: April 21, 1998
    Date of Patent: August 7, 2001
    Assignee: Pfizer Inc.
    Inventors: Tully J. Speaker, H. Fred Clark, Charlotte A. Moser, Paul A. Offit, Manuel Campos, Patrick J. Frenchick
  • Rotavirus reassortant vaccine
    Patent number: 6113910
    Abstract: The present invention provides novel rotavirus reassortants, vaccines employing the novel reassortants and methods for their preparation and administration. One such reassortant contains the gene encoding the v.p.7 neutralization antigen of a human rotavirus. Another reassortant contains the gene encoding the v.p.4 neutralization antigen of a human rotavirus. The remaining genes are provided solely from the bovine rotavirus WC3 strain, or from both the human and bovine strains.
    Type: Grant
    Filed: May 11, 1998
    Date of Patent: September 5, 2000
    Assignees: The Children's Hospital of Philadelphia, The Winstar Institute of Anatomy and Biology
    Inventors: H Fred Clark, Paul Offit, Stanley A. Plotkin
  • Rotavirus reassortant vaccine
    Patent number: 5750109
    Abstract: The present invention provides novel rotavirus reassortants, vaccines employing the novel reassortants and methods for their preparation and administration. One such reassortant contains the gene encoding the v.p.7 neutralization antigen of a human rotavirus. Another reassortant contains the gene encoding the v.p.4 neutralization antigen of a human rotavirus. The remaining genes are provided solely from the bovine rotavirus WC3 strain, or from both the human and bovine strains.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: May 12, 1998
    Assignees: The Wistar Institute of Anatomy & Biology, The Children's Hospital of Philadelphia
    Inventors: H. Fred Clark, Paul Offit, Stanley A. Plotkin
  • Rotavirus reassortant vaccine
    Patent number: 5626851
    Abstract: The present invention provides novel rotavirus reassortants, vaccines employing the novel reassortants and methods for their preparation and administration. One such reassortant contains the gene encoding the v.p.7 neutralization antigen of a human rotavirus. Another reassortant contains the gene encoding the v.p.4 neutralization antigen of a human rotavirus. The remaining genes are provided solely from the bovine rotavirus WC3 strain, or from both the human and bovine strains.
    Type: Grant
    Filed: December 9, 1994
    Date of Patent: May 6, 1997
    Assignees: The Wistar Institute of Anatomy and Biology, The Children's Hospital of Philadelphia
    Inventors: H. Fred Clark, Paul Offit, Stanley A. Plotkin
  • Human rotavirus HCR3A and method of growing said rotavirus
    Patent number: 5610049
    Abstract: The present invention refers generally to a novel human cytopathic rotavirus of serotype 3 (HCR3A) and to its use as a vehicle for the expression of human rotavirus genes. The invention also relates to novel rotavirus reassortants, vaccines employing the novel rotavirus and its reassortants and methods for their preparation and administration.
    Type: Grant
    Filed: May 1, 1991
    Date of Patent: March 11, 1997
    Assignee: The Wistar Institute of Anatomy and Biology
    Inventor: H. Fred Clark
  • Vaccine, method for its preparation, and use thereof in vaccinating humans against rotavirus infection
    Patent number: 4636385
    Abstract: A live rotavirus vaccine against bovine and human rotaviruses comprising a strain of live bovine rotavirus which does not hemagglutinate primate red blood cells, gives at least about 20 fold higher titers when neutralized with antiserum therefor as compared to heterologous bovine or primate rotaviruses, and has a migration pattern of its RNA genome segments when determined by PAGE substantially as shown by lane WC3 in FIG. 1, the strain of bovine rotavirus having been serially passaged in primate kidney tissue culture a sufficient number of times that when administered to humans the vaccine is immunogenic without causing disease.
    Type: Grant
    Filed: February 15, 1985
    Date of Patent: January 13, 1987
    Assignee: The Wistar Institute of Anatomy & Biology
    Inventors: Stanley A. Plotkin, H. Fred Clark