Patents by Inventor H. James Harwood

H. James Harwood has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11492341
    Abstract: The present invention provides compounds useful as inhibitors of ATP citrate lyase (ACLY), compositions thereof, and methods of using the same.
    Type: Grant
    Filed: November 15, 2019
    Date of Patent: November 8, 2022
    Assignee: Nimbus Artemis, Inc.
    Inventors: Silvana Marcel Leit de Moradei, Kevin Kreutter, H. James Harwood, Eric Therrien
  • Publication number: 20200157076
    Abstract: The present invention provides compounds useful as inhibitors of ATP citrate lyase (ACLY), compositions thereof, and methods of using the same.
    Type: Application
    Filed: November 15, 2019
    Publication date: May 21, 2020
    Inventors: Silvana Marcel Leit de Moradei, Kevin Kreutter, H. James Harwood, Eric Therrien
  • Publication number: 20190381045
    Abstract: The present invention provides methods of treating, stabilizing or lessening the severity or progression of a non-alcoholic fatty liver disease using an ACC inhibitor alone or with one or more additional therapeutic agents.
    Type: Application
    Filed: May 13, 2019
    Publication date: December 19, 2019
    Inventors: Geraldine C. Harriman, H. James Harwood, Rosana Kapeller-Libermann, William F. Westlin
  • Patent number: 9944655
    Abstract: The present invention provides compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: April 17, 2018
    Assignee: Gilead Apollo, LLC
    Inventors: Geraldine C. Harriman, Craig E. Masse, H. James Harwood, Sathesh Bhat, Jeremy Robert Greenwood
  • Publication number: 20180021341
    Abstract: The present invention provides methods of treating, stabilizing or lessening the severity or progression of a non-alcoholic fatty liver disease using an ACC inhibitor alone or with one or more additional therapeutic agents.
    Type: Application
    Filed: January 8, 2016
    Publication date: January 25, 2018
    Inventors: Geraldine C. Harriman, H. James Harwood, Rosana Kapeller-Libermann, William F. Westlin
  • Patent number: 7879945
    Abstract: A method of forming a functionalized polymer, the method comprising reacting a living polymer with a compound defined by the formula where R5 includes a monovalent organic group, R6 independently includes a monovalent organic group, each R7 independently includes hydrogen or a monovalent organic group, each R8 independently includes hydrogen or monovalent organic group, R9 includes a monovalent organic group, M is silicon or tin, and x includes an integer from about 2 to about 10, where R5 and R6 may optionally each independently be alkoxy groups, and where R7, R8, and R9 are non-Zerewitinoff organic groups.
    Type: Grant
    Filed: March 16, 2009
    Date of Patent: February 1, 2011
    Assignee: Bridgestone Corporation
    Inventors: Terrence E. Hogan, Christine Rademacher, David F. Lawson, H. James Harwood
  • Publication number: 20090203844
    Abstract: A method of forming a functionalized polymer, the method comprising reacting a living polymer with a compound defined by the formula where R5 includes a monovalent organic group, R6 independently includes a monovalent organic group, each R7 independently includes hydrogen or a monovalent organic group, each R8 independently includes hydrogen or monovalent organic group, R9 includes a monovalent organic group, M is silicon or tin, and x includes an integer from about 2 to about 10, where R5 and R6 may optionally each independently be alkoxy groups, and where R7, R8, and R9 are non-Zerewitinoff organic groups.
    Type: Application
    Filed: March 16, 2009
    Publication date: August 13, 2009
    Inventors: Terrence E. Hogan, Christine Rademacher, David F. Lawson, H. James Harwood
  • Patent number: 7504457
    Abstract: A method of forming a functionalized polymer, the method comprising reacting a living polymer with a compound defined by the formula where R5 includes a monovalent organic group, R6 independently includes a monovalent organic group, each R7 independently includes hydrogen or a monovalent organic group, each R8 independently includes hydrogen or monovalent organic group, R9 includes a monovalent organic group, M is silicon or tin, and x includes an integer from about 2 to about 10, where R5 and R6 may optionally each independently be alkoxy groups, and where R7, R8, and R9 are non-Zerewitinoff organic groups.
    Type: Grant
    Filed: January 13, 2006
    Date of Patent: March 17, 2009
    Assignee: Bridgestone Corporation
    Inventors: Terrence E. Hogan, Christine Rademacher, David F. Lawson, H. James Harwood
  • Patent number: 6979741
    Abstract: Acetyl Coenzyme A Carboxylase inhibitors, pharmaceutical compositions containing such compounds and the use of such compounds to treat for example, Metabolic Syndrome including atherosclerosis, diabetes and obesity.
    Type: Grant
    Filed: February 20, 2003
    Date of Patent: December 27, 2005
    Assignee: Pfizer Inc.
    Inventors: David A. Perry, H. James Harwood
  • Publication number: 20030187254
    Abstract: Acetyl Coenzyme A Carboxylase inhibitors, pharmaceutical compositions containing such compounds and the use of such compounds to treat for example, Metabolic Syndrome including atherosclerosis, diabetes and obesity.
    Type: Application
    Filed: February 20, 2003
    Publication date: October 2, 2003
    Applicant: Pfizer Inc.
    Inventors: David A. Perry, H. James Harwood
  • Patent number: 6602960
    Abstract: A polymerization process comprising the steps of admixing a halogen-containing compound, monomer, and a cobalt complex.
    Type: Grant
    Filed: March 22, 2002
    Date of Patent: August 5, 2003
    Assignee: The University of Akron
    Inventors: H. James Harwood, Anne K. Shim
  • Publication number: 20030055188
    Abstract: Disclosed are cyclic phosphate esters of fumarate—or maleic acids suitable for use as a comonomer, capable of being copolymerized with a monovinylidene aromatic compounds to impart flame resistant properties to the resultant copolymers.
    Type: Application
    Filed: September 20, 2002
    Publication date: March 20, 2003
    Inventors: Steven R. Mitchell, H. James Harwood, William G. Stobby, Duane B. Priddy, Kyung W. Suh
  • Patent number: 6503992
    Abstract: Disclosed are cyclic phosphate esters of fumarate- or maleic acids suitable for use as a comonomer, capable of being copolymerized with a monovinylidene aromatic compounds to impart flame resistant properties to the resultant copolymers.
    Type: Grant
    Filed: July 24, 2001
    Date of Patent: January 7, 2003
    Assignees: The Dow Chemical Company, The University of Akron
    Inventors: Steven R. Mitchell, H. James Harwood, William G. Stobby, Duane B. Priddy, Kyung W. Suh
  • Patent number: 6399731
    Abstract: A method for making a polymer comprising the step of synthesizing a polymer by employing a chain transfer agent having the formula (II) where X and Y are independently selected from oxygen, sulfur, and fully-substituted nitrogen where R1 and R2 are independently selected from hydrogen, halogen, or an organic group, with the proviso that at least one of R1 or R2 be hydrogen or halogen, R3 is an organic group R4 and R5 are independently selected organic groups, with the proviso that R3 is not hydrogen.
    Type: Grant
    Filed: December 2, 1998
    Date of Patent: June 4, 2002
    Assignee: The University of Akron
    Inventors: Brian King, H. James Harwood
  • Publication number: 20020040120
    Abstract: Disclosed are cyclic phosphate esters of fumarate- or maleic acids suitable for use as a comonomer, capable of being copolymerized with a monovinylidene aromatic compounds to impart flame resistant properties to the resultant copolymers.
    Type: Application
    Filed: July 24, 2001
    Publication date: April 4, 2002
    Inventors: Steven R. Mitchell, H. James Harwood, William G. Stobby, Duane B. Priddy, Kyung W. Suh
  • Publication number: 20020016424
    Abstract: A method for making a polymer comprising the step of synthesizing a polymer by employing a chain transfer agent having the formula (II) 1
    Type: Application
    Filed: December 2, 1998
    Publication date: February 7, 2002
    Inventors: BRIAN KING, H. JAMES HARWOOD
  • Patent number: 5616704
    Abstract: The present invention is directed toward anionic polymerization initiators which are soluble in acyclic alkane solvents. The initiators include a solubilized lithio amine having the general formula (A)Li(SOL).sub.y. SOL is a solubilizing component and A is an alkyl, dialkyl or cycloalkyl amine radical or a cyclic amine and y is from about 1 to 4. The cyclic amine has an alkylene, oxy- or amino-alkylene group having from about 3 to about 16 methylene groups. The invention is also directed toward polymers and other products made using the initiator, and methods therefor. Further, the invention contemplates a polymer, a polymer composition and products therefrom, which include a functional group from the reaction product of an amine and an organolithium compound. The resulting polymers may be terminated with a terminating, coupling or linking agent, which may provide the polymer with a multifunctionality.
    Type: Grant
    Filed: April 29, 1996
    Date of Patent: April 1, 1997
    Assignee: Bridgestone Corporation
    Inventors: David F. Lawson, Mark L. Stayer, Jr., David Saffles, H. James Harwood
  • Patent number: 5597875
    Abstract: This invention describes chemical modifications of hydrogenated polymers, particularly thermoplastic elastomers, e.g., Kraton.RTM. G, to increase the chemical resistance thereof. The number of residual reactive unsaturated diene-based mid-blocks were reduced through a post-hydrogenation reaction with an alkyl phenyl ether, e.g., anisole. The anisolated thermoplastic elastomer was then further reacted with benzenesulfonylation and nitration reactions to produce even more useful derivatives thereof.
    Type: Grant
    Filed: June 27, 1995
    Date of Patent: January 28, 1997
    Assignee: University of Akron
    Inventors: H. James Harwood, Steven W. Jolly
  • Patent number: 5589560
    Abstract: A curable composition which comprises:(a) an anhydride-functional polymer obtained by polymerizing under free radical addition polymerization conditions, a monomer mixture comprising:(i) 20 to 75 weight percent of an alkenyl succinic anhydride having the structure: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are each independently hydrogen or alkyl or substituted alkyl of 1 to about 30 carbons; and(ii) 25 to 80 weight percent of at least one (meth)acrylic monomer copolymerizable with the alkenyl succinic anhydride; and, optionally,(iii) 0 to 75 weight percent of at least one unsaturated monomer, other than a (meth)acrylic monomer, which is copolymerizable with the anhydride and the (meth)acrylic monomer; and(b) a compound having an average of at least two functional groups per molecule which are reactive with anhydride groups.
    Type: Grant
    Filed: December 21, 1995
    Date of Patent: December 31, 1996
    Assignee: The Sherwin-Williams Company
    Inventors: Richard S. Valpey, III, Thomas W. Yokoyama, John D. Kraan, H. James Harwood
  • Patent number: 5480951
    Abstract: A curable composition which comprises:(a) an anhydride-functional polymer obtained by polymerizing under free radical addition polymerization conditions, a monomer mixture comprising:(i) 20 to 75 weight percent of an alkenyl succinic anhydride having the structure: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are each independently hydrogen or alkyl or substituted alkyl of 1 to about 30 carbons; and(ii) 25 to 80 weight percent of at least one (meth)acrylic monomer copolymerizable with the alkenyl succinic anhydride; and, optionally,(iii) 0 to 75 weight percent of at least one unsaturated monomer, other than a (meth)acrylic-monomer, which is copolymerizable with the anhydride and the (meth)acrylic monomer; and(b) a compound having an average of at least two functional groups per molecule which are reactive with anhydride groups.
    Type: Grant
    Filed: January 3, 1994
    Date of Patent: January 2, 1996
    Assignee: The Sherwin-Williams Company
    Inventors: Richard S. Valpey, III, Thomas W. Yokoyama, John D. Kraan, H. James Harwood