Patents by Inventor Hélène Benedetti

Hélène Benedetti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 4-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)-3,6-DIHYDROPYRIDINE-1-(2H)-CARBOXAMIDE DERIVATIVES AS LIMK AND/OR ROCK KINASES INHIBITORS FOR USE IN THE TREATMENT OF CANCER
    Publication number: 20230312576
    Abstract: The present invention concerns a compound of formula (1), in particular as LIMK and/or ROCK kinases inhibitors. The present invention also concerns these new inhibitors for use for the treatment of a condition selected in the group consisting of: cancers, virion infections, ocular hypertension and glaucoma formation, Neurofibromatosis type 1 and 2, psoriatic lesions, inflammatory diseases and hyperalgesia, central sensitization and chronic pain, reproduction erectile dysfunction, and neuronal diseases.
    Type: Application
    Filed: May 25, 2021
    Publication date: October 5, 2023
    Inventors: Sylvain ROUTIER, Hélène BENEDETTI, Béatrice LÉE-MÉHEUST, Pascal BONNET, Karen PLÉ, Samia ACI-SÈCHE, Sandrine RUCHAUD, Abdennour BRAKA, Anthony CHAMPIRÉ, Christian ANDRES, Patrick VOURC'H
  • Trisubstituted pyrido[2,3-D]pyrimidines, methods for preparing same and therapeutic uses thereof
    Patent number: 10202372
    Abstract: The present invention relates to compounds of the following general formula (I): wherein: R1 is notably a group —NRaRb, Ra and Rb forming together with the nitrogen atom onto which they are bound, a heterocycle comprising from 5 to 30 atoms, R2 is notably an aryl comprising from 5 to 30 atoms, and R3 is notably an alkenyl comprising from 1 to 20 carbon atoms.
    Type: Grant
    Filed: August 16, 2013
    Date of Patent: February 12, 2019
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S), UNIVERSITE D'ORLEANS
    Inventors: Sylvain Routier, Hélène Benedetti, Frédéric Buron, Marie-Aude Hiebel, Thibault Saurat, Gérald Guillaumet
  • Tools for the identification of Lingo-1, Lingo-2, Lingo-3 and Lingo-4 ligands, and uses thereof
    Patent number: 9494585
    Abstract: The present invention relates to a system comprising coupling products formed by a monomer of a protein chosen from Lingo-1, Lingo-2, Lingo-3 and Lingo-4 and by a probe emitting a signal when said monomer undergoes conformational changes, and to a screening method using said system, enabling ligands of a protein chosen from Lingo-1, Lingo-2, Lingo-3 and Lingo-4 to be identified. The present invention is industrially applicable in the field of methods for detecting molecules, for detecting interaction between molecules and for molecular screening, and also in the medical field.
    Type: Grant
    Filed: April 1, 2011
    Date of Patent: November 15, 2016
    Assignee: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS
    Inventors: Severine Morisset-Lopez, Helene Benedetti
  • TRISUBSTITUTED PYRIDO[2,3-D]PYRIMIDINES, METHODS FOR PREPARING SAME AND THERAPEUTIC USES THEREOF
    Publication number: 20150203489
    Abstract: The present invention relates to compounds of the following general formula (I): wherein: R1 is notably a group —NRaRb, Ra and Rb forming together with the nitrogen atom onto which they are bound, a heterocycle comprising from 5 to 30 atoms, R2 is notably an aryl comprising from 5 to 30 atoms, and R3 is notably an alkenyl comprising from 1 to 20 carbon atoms.
    Type: Application
    Filed: August 16, 2013
    Publication date: July 23, 2015
    Inventors: Sylvain Routier, Hélène Benedetti, Frédéric Buron, Marie-Aude Hiebel, Thibault Saurat, Gérald Guillaumet
  • TOOLS FOR THE IDENTIFICATION OF LINGO-1, LINGO-2, LINGO-3 AND LINGO-4 LIGANDS, AND USES THEREOF
    Publication number: 20130090249
    Abstract: The present invention relates to a system comprising coupling products formed by a monomer of a protein chosen from Lingo-1, Lingo-2, Lingo-3 and Lingo-4 and by a probe emitting a signal when said monomer undergoes conformational changes, and to a screening method using said system, enabling ligands of a protein chosen from Lingo-1, Lingo-2, Lingo-3 and Lingo-4 to be identified. The present invention is industrially applicable in the field of methods for detecting molecules, for detecting interaction between molecules and for molecular screening, and also in the medical field.
    Type: Application
    Filed: April 1, 2011
    Publication date: April 11, 2013
    Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS
    Inventors: Severine Morisset-Lopez, Helene Benedetti