Patents by Inventor H. Lee Sweeney

H. Lee Sweeney has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DUAL AAV-MYO7A VECTORS WITH IMPROVED SAFETY FOR THE TREATMENT OF USH1B
    Publication number: 20230149565
    Abstract: Disclosed are compositions and methods for treating diseases of the mammalian eye, and in particular, complications of the retina associated with Usher syndrome IB (USH1B). Further disclosed are compositions and methods for treating diseases of the mammalian inner ear, and in particular, complications of ear hair cells associated with Usher syndrome IB (USH1B). The disclosure provides improved AAV-based, dual vector systems that facilitate the expression of full-length proteins whose coding sequences exceed that of the polynucleotide packaging capacity of an individual AAV vector. Described herein are modified hybrid dual vector systems that shift the coding sequence for the MY07A tail domain from the front-half vector to the back-half vector by altering the split point (e.g., from between exons 23 and 24, to between exons 21 and 22), in order to eliminate the production of truncated MY07A protein.
    Type: Application
    Filed: March 31, 2021
    Publication date: May 18, 2023
    Applicant: University of Florida Research Foundation, Incorporated
    Inventors: Shannon E. Boye, Sanford L. Boye, H. Lee Sweeney, Kaitlyn Calabro
  • Use of BBI/BBIC for treatment of muscular atrophy and degenerative muscle disease
    Patent number: 8852650
    Abstract: Methods for use of a composition comprising Bowman-Birk Inhibitor (BBI) or a derivative thereof in the treatment and/or prevention of skeletal muscle atrophy, to improve of skeletal muscle function, and to alleviate symptoms and/or slow progression of degenerative skeletal muscle diseases or disorders are provided.
    Type: Grant
    Filed: August 17, 2011
    Date of Patent: October 7, 2014
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: H. Lee Sweeney, Carl A. Morris, Ann R. Kennedy
  • Use of BBI/BBIC for Treatment of Muscular Atrophy and Degenerative Muscle Disease
    Publication number: 20110301075
    Abstract: Methods for use of a composition comprising Bowman-Birk Inhibitor (BBI) or a derivative thereof in the treatment and/or prevention of skeletal muscle atrophy, to improve of skeletal muscle function, and to alleviate symptoms and/or slow progression of degenerative skeletal muscle diseases or disorders are provided.
    Type: Application
    Filed: August 17, 2011
    Publication date: December 8, 2011
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: H. Lee Sweeney, Carl A. Morris, Ann R. Kennedy
  • Bowman-Birk Inhibitor compositions for treatment of muscular atrophy and degenerative muscle disease
    Patent number: 8017161
    Abstract: Methods for use of a composition comprising Bowman-Birk Inhibitor (BBI) or a derivative thereof in the treatment and/or prevention of skeletal muscle atrophy, to improve of skeletal muscle function, and to alleviate symptoms and/or slow progression of degenerative skeletal muscle diseases or disorders are provided.
    Type: Grant
    Filed: July 30, 2004
    Date of Patent: September 13, 2011
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: H. Lee Sweeney, Carl A. Morris, Ann R. Kennedy
  • Bowman-Birk Inhibitor Compositions for Treatment of Muscular Atrophy and Degenerative Muscle Disease
    Publication number: 20080300179
    Abstract: Methods for use of a composition comprising Bowman-Birk Inhibitor (BBI) or a derivative thereof in the treatment and/or prevention of skeletal muscle atrophy, to improve of skeletal muscle function, and to alleviate symptoms and/or slow progression of degenerative skeletal muscle diseases or disorders are provided.
    Type: Application
    Filed: July 30, 2004
    Publication date: December 4, 2008
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: H. Lee Sweeney, Carl A. Morris, Ann R. Kennedy
  • Use of insulin-like growth factor-I in muscle
    Patent number: 6723707
    Abstract: The invention relates compositions and method for the use of insulin-like growth factor to enhance muscle mass and strength.
    Type: Grant
    Filed: February 22, 2000
    Date of Patent: April 20, 2004
    Assignees: The Trustees of the University of Pennsylvania, Massachusetts General Hospital
    Inventors: H. Lee Sweeney, Nadia A. Rosenthal