Patents by Inventor H. Li
H. Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12371302Abstract: A system for managing charging, the charging management system is provided. The system comprises a charging cord management device, a charging cord connector, a device, a first charging cord, and a second charging cord. The charging cord management device is configured with the second charging cord. The charging cord management device is configured to control the second charging cord and the charging cord connector in a direction of the earth gravitational field from a first altitude to a second altitude without user interaction and wherein the first altitude is different from the second altitude. The charging cord connector is configured to be in contact with an apparatus with a height above ground level.Type: GrantFiled: June 30, 2022Date of Patent: July 29, 2025Inventor: Jeff W H Li
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Publication number: 20250190813Abstract: Techniques are described for fine-tuning a neural network. A plurality of fine-tuning layers of a neural network are executed, each corresponding to a respective reference layer of a reference neural network. For each of the fine-tuning layers, a fine-tuning weight matrix is generated based on a reference weight matrix associated with the corresponding reference layer. One or more weights of the fine-tuning weight matrix are then iteratively adjusted based on a comparison of the output of the fine-tuning layer with the output of the corresponding reference layer.Type: ApplicationFiled: December 11, 2023Publication date: June 12, 2025Inventors: Adam H. Li, Alireza Khodamoradi, Benjamin T. Sander, Eric Ford Dellinger, Kristof Denolf, Philip B. James-Roxby, Ralph Wittig
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Publication number: 20250092373Abstract: Natural killer (NK) cells are innate lymphocytes that possess traits of adaptive immunity, such as memory formation. However, the molecular mechanisms by which NK cells persist to form memory cells are not well understood. Using single cell RNA sequencing, we identified two distinct effector NK cell (NKeff) populations following mouse cytomegalovirus (MCMV) infection. Ly6C? memory precursor (MP) NK cells displayed enhanced survival during the contraction phase in a Bcl2-dependent manner, and differentiated into Ly6C+ memory NK cells. Our studies show that a NK cell-intrinsic checkpoint is controlled by the transcription factor Fli1 which limits MP NK formation by regulating early effector NK cell fitness during viral infection. Building upon this discovery, we have designed methods and materials for modulating the molecular mechanisms that regulate memory cell fate in NK cells, such as genetically modified NK cells having a deletion in the gene for the transcription factor Fli1.Type: ApplicationFiled: January 25, 2023Publication date: March 20, 2025Applicant: The Regents of the University of CaliforniaInventors: Timothy E. O'Sullivan, Luke Riggan, Joey H. Li
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Patent number: 12144318Abstract: A personal pet carrier according to an embodiment may include a bag portion to house the lower body of a pet. The sides of the bag may include open slits to facilitate scooping the pet's hind quarters and lower body into the bag. Side straps are provided near the top of the slits. A molle harness system enables the side straps to be positioned at different heights to accommodate the size of the pet. A collar strap and choke prevention strap connected between the collar strap and the front side of the bag may be provided to further secure the pet.Type: GrantFiled: November 7, 2022Date of Patent: November 19, 2024Inventor: Pei H Li
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Publication number: 20240287225Abstract: In at least one embodiment, a process to produce a poly alpha-olefin (PAO) includes introducing a first alpha-olefin to a first catalyst system comprising activator and a metallocene compound into a continuous stirred tank reactor or a continuous tubular reactor under first reactor conditions to form a first reactor effluent. The first alpha-olefin is introduced to the reactor at a flow rate of about 100 g/hr or more. The first reactor effluent includes at least 60 wt % of PAO dimer and 40 wt % or less of higher oligomers, where the higher oligomers are oligomers that have a degree of polymerization of 3 or more. The process includes introducing the first reactor effluent and a second alpha-olefin to a second catalyst composition including an acid catalyst in a second reactor to form a second reactor effluent comprising PAO trimer.Type: ApplicationFiled: April 26, 2024Publication date: August 29, 2024Inventors: Patrick C. Chen, Mark H. Li, Jennifer L. Rapp, Pramod J. Nandapurkar, Brian H. Wahn, Babak Lotfizadehdehkordi, Craig J. Emett, Najeeb M. Kuzhiyil, Jian Yang
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Publication number: 20240268336Abstract: A dual modular system designed for versatile dog transportation allows for the simultaneous carriage of two bags, e.g., one positioned at the wearer's chest and another functioning as a rear- or back-positioned dog carrier. The system may also be used as a single bag either at the front or the back. An inconspicuous magnetic closure may be hidden behind the water bottle pocket on the bags' lower rear, as well as a detachable magnetic closure on the shoulder strap. This setup permits side attachment of bags and facilitates the upper part of the dog carrier bag connecting with the rear bag's shoulder strap. The lower sections of the shoulder straps may be equipped with detachable side release (SR) buckles, allowing individual wearing of the bag at the front or back and enable the wearer to pivot the bag to the front or back through water bottle slits.Type: ApplicationFiled: October 25, 2023Publication date: August 15, 2024Inventor: Pei H. Li
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Publication number: 20240263184Abstract: The invention relates to methods of modulating the expression of one or more genes in a cell by modulating the multimerization of a transcription factor and/or modulating the formation of enhancer-promoter DNA loops, and thereby modulating the expression of the one or more genes. The invention also relates to treating diseases and conditions involving aberrant gene expression by modulating the multimerization of a transcription factor and/or modulating the formation of enhancer-promoter DNA loops. The invention also relates to methods for screening for compounds that modulate expression of one or more genes in a cell.Type: ApplicationFiled: December 14, 2023Publication date: August 8, 2024Inventors: Richard A. Young, Abraham S. Weintraub, Charles H. Li, Alla A. Sigova
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Patent number: 12052472Abstract: Techniques are provided herein for processing video data. The techniques include identifying one or more input factors including one or more of signal quality factors, video content complexity factors, and hardware buffering factors for one or more of a video encoding system and a video playback system; evaluating the one or more input factors to determine adjustments to apply to one or both of the video encoding system and the video playback system; and applying the determine adjustments to the one or both of the video encoding system and the video playback system.Type: GrantFiled: September 25, 2020Date of Patent: July 30, 2024Assignee: Advanced Micro Devices, Inc.Inventors: Adam H. Li, Eugene Kuznetsov, Girish P. Subramaniam, Jihyuk Choi
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Publication number: 20240211762Abstract: An apparatus and method for efficiently creating less computationally intensive nodes for a neural network. In various implementations, a computing system includes a processor and a memory with circuitry that stores multiple input data values to process during inference of a trained neural network. The processor determines, during inference, which node input values, node intermediate values, and node output values of the trained neural network to represent in a respective one of multiple available floating-point formats with less precision. No retraining is performed, but rather, the updates to the representations occur during inference. The processor uses selection criteria to reduce the amount of computation involved for updating the representations during inference while maintaining accuracy above an accuracy threshold. To do so, the processor uses the selection criteria to reduce the number of layers, the number of nodes within a layer, and the number of weight values per node to inspect.Type: ApplicationFiled: December 27, 2022Publication date: June 27, 2024Inventors: Adam H. Li, Eric F. Dellinger, Philip Bryn James-Roxby, Shomy Sanyal, Benjamin Thomas Sander, Ralph Detlef Wittig
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Publication number: 20240147956Abstract: A personal pet carrier according to an embodiment may include a bag portion to house the lower body of a pet. The sides of the bag may include open slits to facilitate scooping the pet's hind quarters and lower body into the bag. Side straps are provided near the top of the slits. A molle harness system enables the side straps to be positioned at different heights to accommodate the size of the pet. A collar strap and choke prevention strap connected between the collar strap and the front side of the bag may be provided to further secure the pet.Type: ApplicationFiled: November 7, 2022Publication date: May 9, 2024Inventor: Pei H Li
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Patent number: 11894449Abstract: Heterostructures include a layer of a two-dimensional material placed on a multiferroic layer. An ordered array of differing polarization domains in the multiferroic layer produces corresponding domains having differing properties in the two-dimensional material. When the multiferroic layer is ferroelectric, the ferroelectric polarization domains in the layer produce local electric fields that penetrate the two-dimensional material. The local electric fields modulate the charge carriers and carrier density on a nanometer length scale, resulting in the formation of lateral p-n or p-i-n junctions, and variations thereof appropriate for device functions.Type: GrantFiled: September 28, 2022Date of Patent: February 6, 2024Assignee: The Government of the United States of America, as represented by the Secretary of the NavyInventors: Berend T. Jonker, Connie H. Li, Kathleen M. McCreary, Olaf M. J. van't Erve
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Patent number: 11873496Abstract: The invention relates to methods of modulating the expression of one or more genes in a cell by modulating the multimerization of a transcription factor and/or modulating the formation of enhancer-promoter DNA loops, and thereby modulating the expression of the one or more genes. The invention also relates to treating diseases and conditions involving aberrant gene expression by modulating the multimerization of a transcription factor and/or modulating the formation of enhancer-promoter DNA loops. The invention also relates to methods for screening for compounds that modulate expression of one or more genes in a cell.Type: GrantFiled: January 9, 2018Date of Patent: January 16, 2024Assignee: Whitehead Institute for Biomedical ResearchInventors: Richard A. Young, Abraham S. Weintraub, Charles H. Li, Alla A. Sigova
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Patent number: 11862716Abstract: Heterostructures include a layer of a two-dimensional material placed on a multiferroic layer. An ordered array of differing polarization domains in the multiferroic layer produces corresponding domains having differing properties in the two-dimensional material. When the multiferroic layer is ferroelectric, the ferroelectric polarization domains in the layer produce local electric fields that penetrate the two-dimensional material. The local electric fields modulate the charge carriers and carrier density on a nanometer length scale, resulting in the formation of lateral p-n or p-i-n junctions, and variations thereof appropriate for device functions.Type: GrantFiled: September 28, 2022Date of Patent: January 2, 2024Assignee: The Government of the United States of America, as represented by the Secretary of the NavyInventors: Berend T. Jonker, Connie H. Li, Kathleen M. McCreary, Olaf M. J. van 't Erve
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Publication number: 20230409868Abstract: Activation scaled clipping layers for neural networks are described. An activation scaled clipping layer processes an output of a neuron in a neural network using a scaling parameter and a clipping parameter. The scaling parameter defines how numerical values are amplified relative to zero. The clipping parameter specifies a numerical threshold that causes the neuron output to be expressed as a value defined by the numerical threshold if the neuron output satisfies the numerical threshold. In some implementations, the scaling parameter is linear and treats numbers within a numerical range as being equivalent, such that any number in the range is scaled by a defined magnitude, regardless of value. Alternatively, the scaling parameter is nonlinear, which causes the activation scaled clipping layer to amplify numbers within a range by different magnitudes. Each scaling and clipping parameter is learnable during training of a machine learning model implementing the neural network.Type: ApplicationFiled: June 20, 2022Publication date: December 21, 2023Applicant: Advanced Micro Devices, Inc.Inventors: Hai Xiao, Adam H Li, Harris Eleftherios Gasparakis
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Publication number: 20230383022Abstract: Processes for making saturated isomerized polyalphaolefm by concurrently isomerizing and hydrogenating unsaturated polyalphaolefm in the presence of a high activity catalyst. Such processes can include contacting at least one unsaturated polyalphaolefm with a catalyst capable of both isomerizing and hydrogenating the polyalphaolefm, wherein the catalyst includes a zeolite or mesoporous material, the zeolite having a silica to alumina mole ratio of from about 5 to about 100 and an alpha value of from about 10 to about 1,000, and the mesoporous material having a collidine uptake of from about 100 ??moles/g to about 500 ?moles/g, wherein a Group VIB to VIIIB metal is incorporated in the catalyst at a concentration of from about 0.01 wt % to about 60.00 wt %, and wherein the zeolite is selected from the group consisting of ZSM-48, ZSM-23, ZSM-12, ZSM-35, ZSM-11, ZSM-57, Beta zeolite, Mordenite zeolite, USY zeolite, zeolite having a MWW framework, and combinations thereof.Type: ApplicationFiled: November 8, 2021Publication date: November 30, 2023Inventors: Mark H. Li, Renyuan Yu, Patrick C. Chen, Anatoly I. Kramer, Wenyih F. Lai
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Publication number: 20230192876Abstract: The present invention relates to methods of treating cancer by administering an anti-CD27 antibody as a monotherapy or as a part of a combination thereof.Type: ApplicationFiled: October 29, 2020Publication date: June 22, 2023Applicant: Merck Sharp & Dohme Corp.Inventors: Elliot K. Chartash, Amy M. Beebe, Jason K. Cheung, Konstantin Dobrenkov, Claire H. Li, Richard Wnek
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Publication number: 20230167207Abstract: The present disclosure relates to processes to produce a poly alpha-olefin (PAO) composition. In some embodiments, a process includes introducing a first C6-C32 alpha-olefin, a second C6-C32 alpha-olefin different than the first C6-C32 alpha-olefin, and a first catalyst system comprising an activator and a metallocene compound into a first reactor, wherein a molar ratio of the first C6-C32 alpha-olefin to the second C6-C32 alpha-olefin is from about 1:5 to about 5:1, by total moles of the first and second C6-C32 alpha-olefin; obtaining a first effluent including a PAO dimer; introducing the first effluent, a third C6-C32 alpha-olefin, and a second catalyst system to an oligomerization unit, wherein the third C6-C32 alpha-olefin is the same or different than the first C6-C32 alpha-olefin and/or second C6-C32 alpha-olefin; obtaining a second effluent; and hydrogenating the second effluent to form the PAO composition.Type: ApplicationFiled: April 28, 2021Publication date: June 1, 2023Inventors: Mark H. Li, Patrick C. Chen
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Patent number: 11661465Abstract: The present disclosure generally relates to process to produce a poly alpha-olefin (PAO), comprising: a) introducing a first alpha-olefin to a first catalyst system comprising non-aromatic hydrocarbon soluble activator and a metallocene compound into a continuous stirred tank reactor or a continuous tubular reactor under first reactor conditions, wherein the first alpha-olefin is preferably introduced to the reactor at a flow rate of about 100 g/hr or more, to form a first reactor effluent comprising PAO (such as at least 60 wt % of PAO dimer and 40 wt % or less of higher oligomers, where the higher oligomers are oligomers that have a degree of polymerization of 3 or more); and b) introducing the first reactor effluent and a second alpha-olefin to a second catalyst composition comprising an acid catalyst, such as BF3, in a second reactor to form a second reactor effluent comprising PAO trimer.Type: GrantFiled: October 28, 2020Date of Patent: May 30, 2023Assignee: ExxonMobil Chemical Patents Inc.Inventors: Jennifer L. Rapp, Patrick C. Chen, Jo Ann M. Canich, Mark H. Li, Jian Yang, Catherine A. Faler, Margaret T. Whalley, Andrew E. Atalla
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Patent number: 11637435Abstract: A system for managing automated charging, the automated charging management system is provided. The system comprises a charging cord management device, a charging cord connector, a power supply, a device, a first charging cord, and a second charging cord. The charging cord management device is configured to locate the power supply. The charging cord management device is configured to align the second charging cord and the charging cord connector with the power supply. The charging cord connector is configured to be in contact with the power supply without user interaction.Type: GrantFiled: August 1, 2021Date of Patent: April 25, 2023Inventor: Jeff W H Li
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Patent number: RE49846Abstract: A CATV/MoCA (cable television/Multimedia over Coax Alliance) signal distribution system includes a first 2-way hybrid splitter for receiving a CATV input signal and splitting it into first and second CATV output signals, a second 2-way hybrid splitter for receiving the second CATV output signal and splitting it into third and fourth CATV output signals, with the latter being connected to a CATV output port. A first diplex filter is receptive of the first CATV output signal, and MoCA signals for providing electrical isolation therebetween and connecting them to a modem port. A second diplex filter is receptive of the third CATV output signal and MoCA signals for providing electrical isolation therebetween and connecting them to a Gateway port. A resistive splitter is connected between the first and second diplex filters and a plurality of individual MoCA signal ports for providing bidirectional MoCA signal flow therebetween.Type: GrantFiled: May 30, 2018Date of Patent: February 20, 2024Assignee: Times Fiber Communications, Inc.Inventors: Brian J. Shapson, Jay Shapson, Matthew M. Shapson, Robert L. Romerein, Rong H. Li, Daniel Deutmeyer