Patents by Inventor H., M. Hanauske-Abel

H., M. Hanauske-Abel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20120095058
    Abstract: The present invention discloses compounds and pharmaceutical compositions which are highly effective at inhibiting the accumulation of spliced and unspliced viral transcripts and their utilization for viral protein synthesis at cellular ribosomes, and at inhibiting the formation of the hypusine residue in cellular eIF-5A precursor proteins, the cellular cofactors that render spliced and unspliced viral transcripts translatable at the ribosomes of infectled cells. The invention further relates to methods of using such compounds and pharmaceutical compositions therefrom for inhibiting or preventing viral protein synthesis. Such inhibition cause a dose-dependent release from the virally induced arrest of the otherwise genetically preprogrammed apoptosis of virally infected cells, and in consequence, triggers their apoptotic ablation and the eradication of the chronic infection-mediating provirus integrated into their genome.
    Type: Application
    Filed: December 1, 2004
    Publication date: April 19, 2012
    Inventors: H., M. Hanauske-Abel, Paul Palumbo, B., M. Cracchiolo, Myung-Hee Park, Edith Wolff, Axel-Rainer Hanauske, Michael B. Mathews, Deepti Saxena, Mainul Hoque