Abstract: An electronic network comprises a plurality of nodes that each comprise a current input and a current output, and at least one transistor arranged as a first current mirror and a second current mirror. The first and the second current mirrors are complementary to each other such that an output of the first current mirror is operably connected to an input of the second current mirror. Resistive connections connect the nodes such that the output of one or more of the nodes is operably connected to the input of one or more of the nodes.

Abstract: An electronic network comprises a plurality of nodes that each comprise a current input and a current output, and at least one transistor arranged as a first current mirror and a second current mirror. The first and the second current mirrors are complementary to each other such that an output of the first current mirror is operably connected to an input of the second current mirror. Resistive connections connect the nodes such that the output of one or more of the nodes is operably connected to the input of one or more of the nodes.

Abstract: An electronic network comprises a plurality of nodes that each comprise a current input and a current output, and at least one transistor arranged as a first current mirror and a second current mirror. The first and the second current mirrors are complementary to each other such that an output of the first current mirror is operably connected to an input of the second current mirror. Resistive connections connect the nodes such that the output of one or more of the nodes is operably connected to the input of one or more of the nodes.

Abstract: A method to screen for reactive chemicals comprises the steps of configuring a set of constructs such that each construct of the set includes a pairwise combination of a chemical entity (A1-Ai) of a chemical library (A) and a chemical entity (B1-Bj) of a chemical library (B). The set of constructs includes essentially every possible pairwise combination of the chemical entities (A1-Ai) of the chemical library (A) and the chemical entities (B1-Bj) of the chemical library (B). The constructs are exposed to a given set of conditions to facilitate reactions or interactions between the chemical entity (A1-Ai) and the chemical entity (B1-Bj) of each construct. The constructs are screened to identify any reactions or interactions, and the chemical entity (A1-Ai) and the chemical entity (B1-Bj) of any constructs where reactions or interactions occurred are identified.

Abstract: A method for calculating the yield of a reaction product comprises providing a solid support with a first link, a reference material, and a second link having an attachment site. Chemistry is performed on the attachment site of the second link in one or more steps to produce a reaction product. The amount of the reference material and the reaction product is measured, and the percentage yield of the reaction product is determined based at least in part on the amount of measured reference material and the amount of measured reaction product.

Abstract: A method for performing chemical synthesis includes the steps of providing a solid support having cross links, a first set of cleavable links within the cross links, and a second set of cleavable links having sites on which to perform chemistry. A first chemical is coupled to the chemistry sites, and the first chemical is reacted with a second chemical to produce a reaction product. The links are cleaved to remove the cross links and to cleave the reaction product from the solid support.

Abstract: A chemical construct for use with solution phase chemistry comprises a reversible attachment unit and one or more attribute conferring units. Such units may include separation attribute conferring units, identification attribute conferring units, and quantitation attribute conferring units.

Abstract: An electronic network comprises a plurality of nodes that each comprise a current input and a current output, and at least one transistor arranged as a first current mirror and a second current mirror. The first and the second current minors are complementary to each other such that an output of the first current mirror is operably connected to an input of the second current mirror. Resistive connections connect the nodes such that the output of one or more of the nodes is operably connected to the input of one or more of the nodes.

Abstract: An electronic network comprises a plurality of nodes that each comprise a current input and a current output, and at least one transistor arranged as a first current mirror and a second current mirror. The first and the second current mirrors are complementary to each other such that an output of the first current mirror is operably connected to an input of the second current mirror. Resistive connections connect the nodes such that the output of one or more of the nodes is resistively connected to the input of one or more of the nodes.

Abstract: The invention provides exemplary systems and methods for processing solid supports. According to one system, a probe is provided having a distal end and a lumen terminating at the distal end. The transport mechanism is adapted to place the distal end of the probe into a well having a plurality of solid supports that are held within a fluid. A detection mechanism is provided to detect the presence or absence of one of the solid supports at the distal end while the distal end is within the fluid. A measuring system is provided to measure the general size of the attached solid support.

Abstract: A method to obtain selected individual polynucleotides or mixtures thereof each of which encodes a peptide and at least one polynucleotide of the mixture encodes a peptide having a target property. The polynucleotides of the invention present in the mixture in detectable, retrievable, and clonable amounts are expressed in a host organism for screening for the target activity. The invention features the ability to synthesize controlled random polynucleotides to produce a predetermined mixture of polynucleotides and to avoid synthesis of a stop codon by adjusting the proportions into which the synthesis pool is subdivided and by adjusting the proportions of activated nucleotides added at each coupling step. A polynucleotide encoding a peptide having a target property can be selected and sequenced to deduce the amino acid sequence of the peptide.