Patents by Inventor H. Mitchell Rubenstein
H. Mitchell Rubenstein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12099045Abstract: A thermal desorption tube for chromatography and mass spectrometry analysis. The thermal desorption tube includes a sorbent and a plurality of focusing agents loaded at known, relative amounts onto the sorbent. Each focusing agent is a compound that chromatographically elutes within a retention time similar to a retention time of a target analyte and has a mass spectrum similar to a mass spectrum of the target analyte. The thermal desorption tube is configured to be further loaded with a sample having the target analyte.Type: GrantFiled: November 18, 2020Date of Patent: September 24, 2024Assignee: United States of America as represented by the Secretary of the Air ForceInventors: H. Mitchell Rubenstein, Anthony Qualley
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Patent number: 11975304Abstract: A system for solventless calibration of volatile or semi-volatile compounds and methods thereof. The system includes a fluid path having a first end configured to be operably coupled to a fluid source and a second end configured to be operably coupled to the analytical instrument. A solid sorbent is disposed along the fluid path and is configured to absorb an analyte. The flow of fluid along the fluid path from the first end to the second end causes absorbed analyte to be desorbed from the solid sorbent at a desired concentration to the instrument.Type: GrantFiled: June 24, 2021Date of Patent: May 7, 2024Assignee: United States of America as represented by the Secretary of the Air ForceInventors: H. Mitchell Rubenstein, Patrick Lewis
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Patent number: 11782039Abstract: A method for reducing the variability, as measured by relative standard deviation (RSD), of an analytical testing technique is provided. This improvement in RSD improves the confidence in the values obtained during field testing. The method includes incorporating a focusing agent into the sampling media, which permits providing sampling media such as thermal desorption tubes preloaded with the focusing agent.Type: GrantFiled: July 21, 2021Date of Patent: October 10, 2023Assignee: United States of America as represented by the Secretary of the Air ForceInventor: H. Mitchell Rubenstein
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Publication number: 20230158497Abstract: A system, apparatus, and method include a pump to deliver vapor including airborne contaminants including organic compounds including a target analyte; a collector to transfer the airborne contaminants by autonomous liquid extraction into a mobile organic liquid phase; a micro-fluidic chamber including immobilized biorecognition elements that bind to analytes delivered from the mobile organic liquid phase; a mechanism to introduce the mobile organic liquid phase to a buffer containing a plurality of substrates causing a series of biochemical reactions that create a change corresponding to a concentration of the target analyte; and a detector to perform real-time analysis that correlates to a concentration of the organic compounds to determine a presence of the target analyte.Type: ApplicationFiled: January 9, 2023Publication date: May 25, 2023Applicant: Government of the United States as represented by the Secretary of the Air ForceInventors: H. Mitchell Rubenstein, Douglas Adkins, Patrick Lewis, John Rogers, Sungbong Kim, Steve Kim, Michael Brothers
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Publication number: 20220074907Abstract: A method for reducing the variability, as measured by relative standard deviation (RSD), of an analytical testing technique is provided. This improvement in RSD improves the confidence in the values obtained during field testing. The method includes incorporating a focusing agent into the sampling media, which permits providing sampling media such as thermal desorption tubes preloaded with the focusing agent.Type: ApplicationFiled: July 21, 2021Publication date: March 10, 2022Applicant: Government of the United States as Represented by the Secretary of the Air ForceInventor: H. Mitchell Rubenstein
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Patent number: 11215596Abstract: A method for reducing the variability, as measured by relative standard deviation (RSD), of an analytical testing technique is provided. This improvement in RSD improves the confidence in the values obtained during field testing. The method includes incorporating a focusing agent into the sampling media, which permits providing sampling media such as thermal desorption tubes preloaded with the focusing agent.Type: GrantFiled: May 17, 2019Date of Patent: January 4, 2022Assignee: United States of America as represented by the Secretary of the Air ForceInventor: H. Mitchell Rubenstein
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Publication number: 20210318276Abstract: A system for solventless calibration of volatile or semi-volatile compounds and methods thereof. The system includes a fluid path having a first end configured to be operably coupled to a fluid source and a second end configured to be operably coupled to the analytical instrument. A solid sorbent is disposed along the fluid path and is configured to absorb an analyte. The flow of fluid along the fluid path from the first end to the second end causes absorbed analyte to be desorbed from the solid sorbent at a desired concentration to the instrument.Type: ApplicationFiled: June 24, 2021Publication date: October 14, 2021Applicant: Government of the United States, as represented by the Secretary of the Air ForceInventors: H. Mitchell Rubenstein, Patrick Lewis
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Patent number: 11099165Abstract: A method for reducing the variability, as measured by relative standard deviation (RSD), of an analytical testing technique is provided. This improvement in RSD improves the confidence in the values obtained during field testing. The method includes incorporating a focusing agent into the sampling media, which permits providing sampling media such as thermal desorption tubes preloaded with the focusing agent.Type: GrantFiled: March 7, 2017Date of Patent: August 24, 2021Assignee: United States of America as represented by the Secretary of the Air ForceInventor: H. Mitchell Rubenstein
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Publication number: 20210140933Abstract: A thermal desorption tube for chromatography and mass spectrometry analysis. The thermal desorption tube includes a sorbent and a plurality of focusing agents loaded at known, relative amounts onto the sorbent. Each focusing agent is a compound that chromatographically elutes within a retention time similar to a retention time of a target analyte and has a mass spectrum similar to a mass spectrum of the target analyte. The thermal desorption tube is configured to be further loaded with a sample having the target analyte.Type: ApplicationFiled: November 18, 2020Publication date: May 13, 2021Applicant: Government of the United States as Represented by the Secretary of the Air ForceInventors: H. Mitchell Rubenstein, Anthony Qualley
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Publication number: 20200292513Abstract: A method for reducing the variability, as measured by relative standard deviation (RSD), of an analytical testing technique is provided. This improvement in RSD improves the confidence in the values obtained during field testing. The method includes incorporating a focusing agent into the sampling media, which permits providing sampling media such as thermal desorption tubes preloaded with the focusing agent.Type: ApplicationFiled: May 17, 2019Publication date: September 17, 2020Applicant: Government of the United States as Represented by the Secretary of the Air ForceInventor: H. Mitchell Rubenstein