Abstract: A cream composition for the topical application of ibuprofen to prevent secondary burn ischemia, inducing changes in the dynamics of blood flow in the region of application. The cream composition includes approximately 0.5 g of 1% ibuprofen cream. A single application of ibuprofen cream to the surface of a skin burn restores vascular patency within the dermis beneath the burn cream to a burn site thwarts burn induced secondary progressive ischemia and the expansion of dermal necrosis.

Abstract: A method and compositions for inhibiting excessive scar formation and adhesions by administering to a patient in need thereof an effective amount of an angiogenesis inhibitor. In the preferred embodiment, the angiogenesis inhibitor is selective, such as a fumagillol derivative like 0-chloroacetylcarbamoyl-Fumagillol (TNP-470, TAP Pharmaceuticals), thalidomide, or a selective drug having more than one activity, such as minocycline or penicilliamine which also have antibiotic activity. Less selective compounds can also be used, such as the cytokine IL12. Patients to be treated include those having experienced trauma, surgical intervention, burns, and other types of injuries. The inhibitor is administered in an amount effective to decrease excessive scarring, defined as formation of high density tissue including cells and connective tissue, without preventing normal wound closure. The inhibitors can be administered systemically and/or locally or topically, as needed.