Patents by Inventor H. Perry Fell, Jr.

H. Perry Fell, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mixed specificity fusion proteins
    Patent number: 5709859
    Abstract: Mixed specificity fusion proteins capable of binding to cellular adhesion molecules have been produced. The fusion proteins contain a polypeptide region, such as an IgG constant region, operatively attached to at least two binding regions each of which corresponds to either an extracellular domain of a cell surface receptor for cellular adhesion molecules, or a variable region of an antibody directed to a cellular adhesion molecule.A method of inhibiting inflammation is a patient is disclosed in which the present fusion proteins are administered to a patient to inhibit the attachment of inflammatory cells to vascular endothelium.A method of inhibiting metastasis is disclosed in which the present fusion proteins are administered to a patient to inhibit the metastasis of responsive tumor cells.
    Type: Grant
    Filed: January 24, 1991
    Date of Patent: January 20, 1998
    Assignee: Bristol-Myers Squibb Company
    Inventors: Alejandro A. Aruffo, Peter S. Linsley, Jeffrey A. Ledbetter, Nitin K. Damle, H. Perry Fell, Jr.
  • Production of chimeric antibodies by homologous recombination
    Patent number: 5482856
    Abstract: A process for producing chimeric antibodies using novel recombinant DNA vectors and homologous recombination in vivo is described. The recombinant DNA constructs of the invention can be used to transfect antibody producing cells so that targeted homologous recombination occurs in the transfected cells leading to gene modification and the production of chimeric antibody molecules by the transfected cells.
    Type: Grant
    Filed: April 12, 1993
    Date of Patent: January 9, 1996
    Assignee: Oncogen Inc.
    Inventors: H. Perry Fell, Jr., Kim R. Folger-Bruce, Susan M. Yarnold
  • Production of chimeric antibodies by homologous recombination
    Patent number: 5202238
    Abstract: A process for producing chimeric antibodies using novel recombinant DNA vectors and homologous recombination in vivo is described. The recombinant DNA constructs of the invention can be used to transfect antibody producing cells so that targeted homologous recombination occurs in the transfected cells leading to gene modification and the production of chimeric antibody molecules by the transfected cells.
    Type: Grant
    Filed: January 22, 1990
    Date of Patent: April 13, 1993
    Assignee: Oncogen
    Inventors: H. Perry Fell, Jr., Kim R. Folger-Bruce