Patents by Inventor H. Randall Bell
H. Randall Bell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9656261Abstract: Aspects of the disclosure provide a microfluidic chip to facilitate DNA analysis. The microfluidic chip includes a first domain configured for polymerase chain reaction (PCR) amplification of DNA fragments, a dilution domain coupled to the first domain to dilute a PCR mixture received from the first domain, and a second domain that is coupled to the dilution domain so as to receive the amplified DNA fragments. The second domain includes a separation channel that is configured to perform electrophoretic separation of the amplified DNA fragments. In addition, the disclosure provides a DNA analyzer to act on the microfluidic chip to perform an integrated single chip DNA analysis.Type: GrantFiled: March 4, 2011Date of Patent: May 23, 2017Assignees: LEIDOS INNOVATIONS TECHNOLOGY, INC., ZyGEM CORPORATION LTD., UNIVERSITY OF VIRGINIA PATENT FOUNDATIONInventors: H. Randall Bell, Joan M Bienvenue, John W Pettit, James P Landers, Jessica V Norris, Orion N Scott, Daniel J Marchiarullo, Daniel C Leslie
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Patent number: 9067207Abstract: Aspects of the disclosure provides a DNA analyzer to facilitate an integrated single-chip DNA analysis. The DNA analyzer includes an interface for coupling a microfluidic chip to the DNA analyzer. The microfluidic chip includes a first domain configured for polymerase chain reaction (PCR) amplification of DNA fragments, and a second domain fluidically coupled to the first domain to receive the DNA fragments and perform electrophoretic separation of the DNA fragments. The DNA fragments are tagged with fluorescent labels. The DNA analyzer includes a detection module to excite the fluorescent labels to emit fluorescence and detect the emitted fluorescence. The detection module includes a laser source, a set of optical elements, a filter module and a photo-detector.Type: GrantFiled: March 4, 2011Date of Patent: June 30, 2015Assignees: UNIVERSITY OF VIRGINIA PATENT FOUNDATION, ZYGEM CORPORATION LTD., Lockheed Martin CorporationInventors: H. Randall Bell, John W Pettit, James P Landers, Joan M Bienvenue, Daniel J Marchiarullo, Brian E Root, Orion N Scott
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Publication number: 20110229897Abstract: Aspects of the disclosure provides a DNA analyzer to facilitate an integrated single-chip DNA analysis. The DNA analyzer includes an interface for coupling a microfluidic chip to the DNA analyzer. The microfluidic chip includes a first domain configured for polymerase chain reaction (PCR) amplification of DNA fragments, and a second domain fluidically coupled to the first domain to receive the DNA fragments and perform electrophoretic separation of the DNA fragments. The DNA fragments are tagged with fluorescent labels. The DNA analyzer includes a detection module to excite the fluorescent labels to emit fluorescence and detect the emitted fluorescence. The detection module includes a laser source, a set of optical elements, a filter module and a photo-detector.Type: ApplicationFiled: March 4, 2011Publication date: September 22, 2011Applicant: LOCKHEED MARTIN CORPORATIONInventors: H.Randall Bell, John W. Pettit, James P. Landers, Joan M. Bienvenue, Daniel J. Marchiarullo, Brian E. Root, Orion N. Scott
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Publication number: 20110229898Abstract: Aspects of the disclosure provide a microfluidic chip to facilitate DNA analysis. The microfluidic chip includes a first domain configured for polymerase chain reaction (PCR) amplification of DNA fragments, a dilution domain coupled to the first domain to dilute a PCR mixture received from the first domain, and a second domain that is coupled to the dilution domain so as to receive the amplified DNA fragments. The second domain includes a separation channel that is configured to perform electrophoretic separation of the amplified DNA fragments. In addition, the disclosure provides a DNA analyzer to act on the microfluidic chip to perform an integrated single chip DNA analysis.Type: ApplicationFiled: March 4, 2011Publication date: September 22, 2011Applicant: LOCKHEED MARTIN CORPORATIONInventors: H. Randall Bell, Joan M. Bienvenue, John W. Pettit, James P. Landers, Jessica V. Norris, Orion N. Scott, Daniel J. Marchiarullo, Daniel C. Leslie
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Publication number: 20110070578Abstract: Aspects of the disclosure provide a microfluidic chip to facilitate DNA analysis. The microfluidic chip includes a first domain configured for polymerase chain reaction (PCR) amplification of DNA fragments, a dilution domain coupled to the first domain to dilute a PCR mixture received from the first domain, and a second domain that is coupled to the dilution domain so as to receive the amplified DNA fragments. The second domain includes a separation channel that is configured to perform electrophoretic separation of the amplified DNA fragments. In addition, the disclosure provides a DNA analyzer to act on the microfluidic chip to perform an integrated single chip DNA analysis.Type: ApplicationFiled: March 10, 2010Publication date: March 24, 2011Applicant: LOCKHEED MARTIN CORPORATIONInventors: H. Randall Bell, Abby MacKness, Joan Bienvenue, John W. Pettit, James P. Landers
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Publication number: 20110065101Abstract: Aspects of the disclosure provide a microfluidic chip. The microfluidic chip includes a first domain configured for polymerase chain reaction (PCR) amplification of DNA fragments, and a second domain for electrophoretic separation. The first domain includes at least a first reaction reservoir designated for PCR amplification based on a first sample, and a second reaction reservoir designated for PCR amplification based on a second sample. The second domain includes at least a first separation unit coupled to the first reaction reservoir to received first amplified DNA fragments based on the first sample, and a second separation unit coupled to the second reaction reservoir to received second amplified DNA fragments based on the second sample. The first separation unit is configured to perform electrophoretic separation for the first amplified DNA fragments, and the second separation unit is configured to perform electrophoretic separation for the second amplified DNA fragments.Type: ApplicationFiled: March 2, 2010Publication date: March 17, 2011Applicant: LOCKHEED MARTIN CORPORATIONInventors: H. Randall Bell, Joan Bienvenue, James P. Landers, John W. Pettit, Abby MacKness