Patents by Inventor H. Sam Bergh

H. Sam Bergh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8592220
    Abstract: The present invention discloses an apparatus and method for rapid analysis of members of a combinatorial library. The apparatus includes a plurality of reactor vessels for containing individual library members, a fluid handling system that apportions a test fluid about equally between each of the vessels and a housing for enclosing the reactor vessels, the housing defining a pressure chamber, wherein the housing is configured to sustain a pressure substantially above atmospheric pressure. This allows for simultaneous screening of library members at high pressure by providing a small pressure differential on reactor components. The disclosed apparatus is especially useful for screening library members based on their ability to catalyze the conversion of fluid reactants.
    Type: Grant
    Filed: October 26, 2007
    Date of Patent: November 26, 2013
    Assignee: Intermolecular, Inc.
    Inventors: H. Sam Bergh, Jason Wells, Victor Wong, John Gallipeo, Lynn Van Erden, Anthony F. Volpe, Jeffrey Maag
  • Patent number: 7758814
    Abstract: A microfluidic fluid distribution manifold includes a common port and a plurality of fluidic channels spirally wound around the common port. Each fluidic channel connects the common port to an independent port and provides essentially the same flow resistance to a fluid flowing therethrough. A fixture for the flow restrictor allows fluid flows to be communicated between the flow restrictor and a larger system such as a parallel reactor system.
    Type: Grant
    Filed: June 3, 2005
    Date of Patent: July 20, 2010
    Assignee: Freeslate, Inc.
    Inventors: Daniel M. Pinkas, H. Sam Bergh, Shenheng Guan, Nallakkan Arvindan
  • Publication number: 20100144539
    Abstract: The present invention discloses an apparatus and method for rapid analysis of members of a combinatorial library. The apparatus includes a plurality of reactor vessels for containing individual library members, a fluid handling system that apportions a test fluid about equally between each of the vessels and a housing for enclosing the reactor vessels, the housing defining a pressure chamber, wherein the housing is configured to sustain a pressure substantially above atmospheric pressure. This allows for simultaneous screening of library members at high pressure by providing a small pressure differential on reactor components. The disclosed apparatus is especially useful for screening library members based on their ability to catalyze the conversion of fluid reactants.
    Type: Application
    Filed: October 26, 2007
    Publication date: June 10, 2010
    Applicant: Symyx Technologies, Inc.
    Inventors: H. Sam Bergh, Jason Wells, Victor Wong, John Gallipeo, Lynn Van Erden, Anthony F. Volpe, Jeffrey Maag
  • Patent number: 7281408
    Abstract: Gas chromatographs of the invention generally comprise four or more analysis channels. Specifically, four or more gas chromatography columns are configured for parallel analysis of four or more gaseous samples with detection being effected using a microdetector array comprising four or more microdetectors. In one embodiment, the four or more microdetectors 510 are microfabricated detectors, and are integrally formed with a substrate or with one or more microchip bodies mounted on a substrate. In a preferred embodiment, a microdetector array comprises four or more thermal conductivity detectors having one or more thin-film detection filaments. A preferred heated environment for highly parallel gas chromatographs is also disclosed.
    Type: Grant
    Filed: November 20, 2003
    Date of Patent: October 16, 2007
    Assignee: Symyx Technologies, Inc.
    Inventors: Ravi Srinivasan, Daniel M. Pinkas, Shenheng Guan, Michael Myslovaty, Mikhail Spitkovsy, James R. Engstrom, H. Sam Bergh
  • Patent number: 7255474
    Abstract: A library of material samples is provided in a condition suitable for imaging using infrared (IR) spectroscopy. The samples are provided to one or more detection cells, each of the cells including or containing a reflective surface. Preferably, for imaging, an energy source (e.g. a source of infrared radiation) provides energy to the detection cells to interact with the samples. Thereafter, images (e.g., spectra) related to the samples are created based upon the interaction.
    Type: Grant
    Filed: July 28, 2004
    Date of Patent: August 14, 2007
    Assignee: Symyx Technologies, Inc.
    Inventors: Peijun Cong, Shenheng Guan, Stephen Cypes, Jason Wells, H. Sam Bergh
  • Patent number: 7150994
    Abstract: Parallel flow reaction systems comprising four or more reaction channels are disclosed. Distribution systems, and parallel flow reaction systems comprising such distribution systems are also disclosed. Specifically, the distribution systems comprise one or more subsystems, including for example, a flow-partitioning subsystem for providing a different flow rate to each of the four or more reactors, a pressure-partitioning subsystem for providing a different reaction pressure in the reaction cavity of each of the four or more reactors, and a feed-composition subsystem for providing a different feed composition to each of the four or more reactors. In preferred embodiments, the one or more subsystems can comprise at least one set of four or more flow restrictors, each of the four or more flow restrictors having a flow resistance that varies relative to other flow restrictors in the set.
    Type: Grant
    Filed: March 7, 2001
    Date of Patent: December 19, 2006
    Assignee: Symyx Technologies, Inc.
    Inventors: H. Sam Bergh, James R. Engstrom, Shenheng Guan, Daniel Meron Pinkas, Kyle W. Self
  • Patent number: 7122156
    Abstract: Parallel flow reaction systems comprising four or more reaction channels are disclosed. Distribution systems, and parallel flow reaction systems comprising such distribution systems are also disclosed. Specifically, the distribution systems comprise a feed-composition subsystem for providing a different feed composition to each of the four or more reactors. In preferred embodiments, the feed composition subsystem comprises at least one set of four or more feed-component flow restrictors, each of the four or more feed-component flow restrictors having a flow resistance that varies relative to other flow restrictors in the set.
    Type: Grant
    Filed: March 8, 2001
    Date of Patent: October 17, 2006
    Assignee: Symyx Technologies, Inc.
    Inventors: H. Sam Bergh, James R. Engstrom, Shenheng Guan, Daniel Meron Pinkas, Kyle W. Self
  • Patent number: 7118917
    Abstract: Parallel flow chemical processing systems, such as parallel flow chemical reaction systems are disclosed. These systems are adapted to simultaneously and independently vary temperature between separate flow channels, preferably by employing separate, individual heating elements in thermal communication with each of four or more parallel flow reactors. The flow reactors are preferably isolated from each other using a thermal isolation system comprising fluid-based heat exchange. In preferred embodiments, the axial heat flux can be fixedly or controllably varied.
    Type: Grant
    Filed: March 7, 2002
    Date of Patent: October 10, 2006
    Assignee: Symyx Technologies, Inc.
    Inventors: H. Sam Bergh, Shenheng Guan, James R. Engstrom, Steffen Hardt, Astrid Lohf, Frank Michel
  • Patent number: 7071000
    Abstract: A method for sampling reaction products includes delivering a reactant through a sampling probe to contact a substance deposited on a substrate and reacting the reactant to form a reaction product. At least a portion of the reaction product is withdrawn through the sampling probe and analyzed. The sampling probe is contacted with the substrate during at least a portion of the delivering, reacting and withdrawing steps.
    Type: Grant
    Filed: December 30, 2002
    Date of Patent: July 4, 2006
    Assignee: Symyx Technologies, Inc.
    Inventors: Youqi Wang, Peijun Cong, Tony N. Wheeler, Lynn Thomas Van Erden, H. Sam Bergh
  • Patent number: 6902934
    Abstract: A chemical processing microsystem useful for identifying and optimizing, materials (e.g., catalysts) that enhance chemical processes or for characterizing and/or optimizing chemical processes is disclosed. The chemical processing microsystem comprises a plurality of microreactors 600 and, in a preferred embodiment, a plurality of microseparators 900 integral with the chemical processing microsystem 10. The microreactors 600 are preferably diffusion-mixed microreactors formed in a plurality of laminae that include a modular, interchangeable candidate-material array 100. The material array 100 comprises a plurality of different candidate materials (e.g., catalysts), preferably arranged at separate, individually addressable portions of a substrate (e.g., wafer). The microseparators 900 are similarly formed in a plurality of laminae that include a modular, interchangeable adsorbent array 700.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: June 7, 2005
    Assignee: Symyx Technologies, Inc.
    Inventors: H. Sam Bergh, Shenheng Guan
  • Patent number: 6890493
    Abstract: A chemical processing microsystem useful for identifying and optimizing materials (e.g., catalysts) that enhance chemical processes or for characterizing and/or optimizing chemical processes is disclosed. The chemical processing microsystem comprises a plurality of microreactors 600 and, in a preferred embodiment, a plurality of microseparators 900 integral with the chemical processing microsystem 10. The microreactors 600 are preferably diffusion-mixed microreactors formed in a plurality of laminae that include a modular, interchangeable candidate-material array 100. The material array 100 comprises a plurality of different candidate materials (e.g., catalysts), preferably arranged at separate, individually addressable portions of a substrate (e.g., wafer). The microseparators 900 are similarly formed in a plurality of laminae that include a modular, interchangeable adsorbent array 700.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: May 10, 2005
    Assignee: Symyx Technologies, Inc.
    Inventors: H. Sam Bergh, Shenheng Guan
  • Patent number: 6864091
    Abstract: A sampling probe for delivering a reactant to a substance deposited on a substrate to form a reaction product and for transporting the reaction product to a product analyzer for analysis. The probe includes a tip positionable over the substance on the substrate. The probe has a recess in the tip sized and shaped for receiving at least a portion of the reaction product. The probe has a product sampling passage extending from the recess adapted for connection to the product analyzer for transporting the portion of the reaction product to the product analyzer. Further, a reactant delivery passage extends to an outlet at the recess for delivering reactant to the substance on the substrate to form the reaction product.
    Type: Grant
    Filed: August 31, 2000
    Date of Patent: March 8, 2005
    Assignee: Symyx Technologies, Inc.
    Inventors: Youqi Wang, Peijun Cong, Tony N. Wheeler, Lynn Thomas Van Erden, H. Sam Bergh
  • Publication number: 20040139784
    Abstract: Gas chromatographs of the invention generally comprise four or more analysis channels. Specifically, four or more gas chromatography columns are configured for parallel analysis of four or more gaseous samples with detection being effected using a microdetector array comprising four or more microdetectors. In one embodiment, the four or more microdetectors 510 are microfabricated detectors, and are integrally formed with a substrate or with one or more microchip bodies mounted on a substrate. In a preferred embodiment, a microdetector array comprises four or more thermal conductivity detectors having one or more thin-film detection filaments. A preferred heated environment for highly parallel gas chromatographs is also disclosed.
    Type: Application
    Filed: November 20, 2003
    Publication date: July 22, 2004
    Applicant: Symyx Technologies, Inc.
    Inventors: Ravi Srinivasan, Daniel Meron Pinkas, Shenheng Guan, Michael Myslovaty, Mikhail Spitkovsy, James R. Engstrom, H. Sam Bergh
  • Patent number: 6749814
    Abstract: A chemical processing microsystem useful for identifying and optimizing materials (e.g., catalysts) that enhance chemical processes or for characterizing and/or optimizing chemical processes is disclosed. The chemical processing microsystem comprises a plurality of microreactors 600 and, in a preferred embodiment, a plurality of microseparators 900 integral with the chemical processing microsystem 10. The microreactors 600 are preferably diffusion-mixed microreactors formed in a plurality of laminae that include a modular, interchangeable candidate-material array 100. The material array 100 comprises a plurality of different candidate materials (e.g., catalysts), preferably arranged at separate, individually addressable portions of a substrate (e.g., wafer). The microseparators 900 are similarly formed in a plurality of laminae that include a modular, interchangeable adsorbent array 700.
    Type: Grant
    Filed: March 3, 2000
    Date of Patent: June 15, 2004
    Assignee: Symyx Technologies, Inc.
    Inventors: H. Sam Bergh, Shenheng Guan
  • Patent number: 6742544
    Abstract: A novel gas injection valve for injecting discrete charges of gas into a mobile phase or carrier stream is provided. Injection valves of the invention comprise a plurality of microvalves capable of receiving gas at different pressures and emitting discrete charges of gas at approximately the same pressure. The invention further provides for parallel injection valve arrays capable of injecting multiple samples substantially simultaneously and a method of injecting discrete gas samples at a controlled pressure to a high-resolution gas chromatograph.
    Type: Grant
    Filed: March 6, 2002
    Date of Patent: June 1, 2004
    Assignee: Symyx Technologies, Inc.
    Inventors: H. Sam Bergh, Daniel M. Pinkas, Frank Doffing, Michael Klaus, Friedhelm Schoenfeld
  • Patent number: 6737026
    Abstract: A chemical processing microsystem useful for identifying and optimizing materials (e.g., catalysts) that enhance chemical processes or for characterizing and/or optimizing chemical processes is disclosed. The chemical processing microsystem comprises a plurality of microreactors 600 and, in a preferred embodiment, a plurality of microseparators 900 integral with the chemical processing microsystem 10. The microreactors 600 are preferably diffusion-mixed microreactors formed in a plurality of laminae that include a modular, interchangeable candidate-material array 100. The material array 100 comprises a plurality of different candidate materials (e.g., catalysts), preferably arranged at separate, individually addressable portions of a substrate (e.g., wafer). The microseparators 900 are similarly formed in a plurality of laminae that include a modular, interchangeable adsorbent array 700.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: May 18, 2004
    Assignee: Symyx Technologies, Inc.
    Inventors: H. Sam Bergh, Shenheng Guan
  • Patent number: 6701774
    Abstract: Gas chromatographs of the invention generally comprise four or more analysis channels. Specifically, four or more gas chromatography columns are configured for parallel analysis of four or more gaseous samples with detection being effected using a microdetector array comprising four or more microdetectors. In one embodiment, the four or more microdetectors 510 are microfabricated detectors, and are integrally formed with a substrate or with one or more microchip bodies mounted on a substrate. In a preferred embodiment, a microdetector array comprises four or more thermal conductivity detectors having one or more thin-film detection filaments. A preferred heated environment for highly parallel gas chromatographs is also disclosed.
    Type: Grant
    Filed: March 7, 2001
    Date of Patent: March 9, 2004
    Assignee: Symyx Technologies, Inc.
    Inventors: Ravi Srinivasan, Daniel Meron Pinkas, Shenheng Guan, Michael Myslovaty, Michael Spitkovsky, James R. Engstrom, H. Sam Bergh
  • Publication number: 20030100120
    Abstract: A method for sampling reaction products includes delivering a reactant through a sampling probe to contact a substance deposited on a substrate and reacting the reactant to form a reaction product. At least a portion of the reaction product is withdrawn through the sampling probe and analyzed. The sampling probe is contacted with the substrate during at least a portion of the delivering, reacting and withdrawing steps.
    Type: Application
    Filed: December 30, 2002
    Publication date: May 29, 2003
    Applicant: Symyx Technologies, Inc.
    Inventors: Youqi Wang, Peijun Cong, Tony N. Wheeler, Lynn Thomas Van Erden, H. Sam Bergh
  • Publication number: 20020170976
    Abstract: Parallel flow chemical processing systems, such as parallel flow chemical reaction systems are disclosed. These systems are adapted to simultaneously and independently vary temperature between separate flow channels, preferably by employing separate, individual heating elements in thermal communication with each of four or more parallel flow reactors. The flow reactors are preferably isolated from each other using a thermal isolation system comprising fluid-based heat exchange. In preferred embodiments, the axial heat flux can be fixedly or controllably varied.
    Type: Application
    Filed: March 7, 2002
    Publication date: November 21, 2002
    Inventors: H. Sam Bergh, Shenheng Guan, James R. Engstrom, Steffen Hardt, Astrid Lohf, Frank Michel
  • Publication number: 20020127146
    Abstract: A novel gas injection valve for injecting discrete charges of gas into a mobile phase or carrier stream is provided. Injection valves of the invention comprise a plurality of microvalves capable of receiving gas at different pressures and emitting discrete charges of gas at approximately the same pressure. The invention further provides for parallel injection valve arrays capable of injecting multiple samples substantially simultaneously and a method of injecting discrete gas samples at a controlled pressure to a high-resolution gas chromatograph.
    Type: Application
    Filed: March 6, 2002
    Publication date: September 12, 2002
    Applicant: Symyx Technologies, Inc.
    Inventors: H. Sam Bergh, Daniel M. Pinkas