Patents by Inventor H. Steve Zhang

H. Steve Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR TREATING HUNTINGTON'S DISEASE
    Publication number: 20230414710
    Abstract: Disclosed herein are compositions comprising non-naturally occurring zinc finger domains, fusion proteins comprising these zinc finger domains, polynucleotides encoding these proteins, cells expressing these proteins and pharmaceutical compositions comprising these proteins or polynucleotides as well as methods of modifying an Htt gene using these compositions for treating or preventing Huntington's Disease.
    Type: Application
    Filed: June 29, 2023
    Publication date: December 28, 2023
    Inventors: Jeffrey C. Miller, Edward J. Rebar, H. Steve Zhang
  • VARIANTS OF CAS NUCLEASE
    Publication number: 20230313159
    Abstract: Disclosed herein are variants of a Cas nuclease, polynucleotide encoding the same, compositions thereof, expression vectors, and methods of use thereof, for the generation of transgenic cells, tissues, plants, and animals. The compositions, vectors, and methods of the present invention are also useful in gene therapy and cell therapy techniques.
    Type: Application
    Filed: July 26, 2021
    Publication date: October 5, 2023
    Inventors: H. Steve ZHANG, Qi ZHENG
  • TAU MODULATORS AND METHODS AND COMPOSITIONS FOR DELIVERY THEREOF
    Publication number: 20230270774
    Abstract: The present disclosure is in the field of diagnostics and therapeutics for Alzheimer's Disease.
    Type: Application
    Filed: October 13, 2022
    Publication date: August 31, 2023
    Applicants: Sangamo Therapeutics, Inc., The General Hospital Corporation
    Inventors: Annemarie Ledeboer, Bryan Zeitler, H. Steve Zhang, Sarah DeVos, Bradley T. Hyman, Susanne Wegmann
  • Methods and compositions for treating Huntington's Disease
    Patent number: 11723952
    Abstract: Disclosed herein are compositions comprising non-naturally occurring zinc finger domains, fusion proteins comprising these zinc finger domains, polynucleotides encoding these proteins, cells expressing these proteins and pharmaceutical compositions comprising these proteins or polynucleotides as well as methods of modifying an Htt gene using these compositions for treating or preventing Huntington's Disease.
    Type: Grant
    Filed: November 16, 2020
    Date of Patent: August 15, 2023
    Assignee: Sangamo Therapeutics, Inc.
    Inventors: Jeffrey C. Miller, Edward J. Rebar, H. Steve Zhang
  • METHODS AND COMPOSITIONS FOR TREATING THALASSEMIA OR SICKLE CELL DISEASE
    Publication number: 20220380756
    Abstract: Provided herein are methods and compositions for treating genetic blood cell diseases, e.g. sickle cell disease and thalassemia, by correcting genetic mutation or inserting exogenous globin gene using CRISPR/Cas system.
    Type: Application
    Filed: June 29, 2020
    Publication date: December 1, 2022
    Inventors: Xuefeng WANG, Ling-jie KONG, H. Steve ZHANG, Ruby Yanru TSAI
  • Tau modulators and methods and compositions for delivery thereof
    Patent number: 11504389
    Abstract: The present disclosure is in the field of diagnostics and therapeutics for Alzheimer's Disease.
    Type: Grant
    Filed: December 1, 2017
    Date of Patent: November 22, 2022
    Assignees: Sangamo Therapeutics, Inc., The General Hospital Corporation
    Inventors: Annemarie Ledeboer, Bryan Zeitler, H. Steve Zhang, Sarah DeVos, Bradley T. Hyman, Susanne Wegmann
  • Zinc finger protein compositions for modulation of huntingtin (Htt)
    Patent number: 11421007
    Abstract: The present disclosure is in the field of modulation of Htt gene expression and HTT protein levels.
    Type: Grant
    Filed: April 17, 2019
    Date of Patent: August 23, 2022
    Assignees: Sangamo Therapeutics, Inc., CHDI Foundation, Inc.
    Inventors: Steven Froelich, Ignacio Munoz-Sanjuan, Edward J. Rebar, Bryan Zeitler, H. Steve Zhang
  • Zinc finger protein compositions for modulation of huntingtin (Htt)
    Patent number: 11279739
    Abstract: The present disclosure is in the field of modulation of Htt gene expression and HTT protein levels.
    Type: Grant
    Filed: April 17, 2019
    Date of Patent: March 22, 2022
    Assignees: Sangamo Therapeutics, Inc., CHDI Foundation, Inc.
    Inventors: Steven Froelich, Ignacio Munoz-Sanjuan, Edward J. Rebar, Bryan Zeitler, H. Steve Zhang
  • HTT REPRESSORS AND USES THEREOF
    Publication number: 20220064237
    Abstract: Disclosed herein are HTT repressors and methods and compositions for use of these HTT repressors. Disclosed herein are methods and compositions for diagnosing, preventing and/or treating Huntington's Disease. In particular, provided herein are methods and compositions for modifying (e.g., modulating expression of) an HD HTT allele so as to prevent or treat Huntington Disease, including mHTT repressors (that repress mHTT transcripts and thus also repress mHTT protein expression).
    Type: Application
    Filed: January 15, 2020
    Publication date: March 3, 2022
    Inventors: Galen Carey, Matthew Chiocco, Vivian Choi, Brian Felice, Steven Froelich, Debra Klatte, Jeffrey Miller, David Paschon, Edward Rebar, Bryan Zeitler, Lei Zhang, H. Steve Zhang
  • HTT REPRESSORS AND USES THEREOF
    Publication number: 20210369872
    Abstract: Disclosed herein are Htt repressors and methods and compositions for use of these Htt repressors.
    Type: Application
    Filed: August 13, 2021
    Publication date: December 2, 2021
    Inventors: Steven Froelich, Jeffrey C. Miller, David Paschon, Edward J. Rebar, Bryan Zeitler, H. Steve Zhang
  • Htt repressors and uses thereof
    Patent number: 11123443
    Abstract: Disclosed herein are Htt repressors and methods and compositions for use of these Htt repressors.
    Type: Grant
    Filed: August 26, 2019
    Date of Patent: September 21, 2021
    Assignee: Sangamo Therapeutics, Inc.
    Inventors: Steven Froelich, Jeffrey C. Miller, David Paschon, Edward J. Rebar, Bryan Zeitler, H. Steve Zhang
  • Methods and compositions for treating Huntington's Disease
    Patent number: 11110154
    Abstract: Disclosed herein are methods and compositions for treating or preventing Huntington's Disease.
    Type: Grant
    Filed: May 7, 2015
    Date of Patent: September 7, 2021
    Assignees: Sangamo Therapeutics, Inc., CHDI Foundation, Inc.
    Inventors: Steven Froelich, Seung Kwak, Ignacio Munoz-Sanjuan, H. Steve Zhang
  • METHODS AND COMPOSITIONS FOR TREATING HUNTINGTON'S DISEASE
    Publication number: 20210060124
    Abstract: Disclosed herein are compositions comprising non-naturally occurring zinc finger domains, fusion proteins comprising these zinc finger domains, polynucleotides encoding these proteins, cells expressing these proteins and pharmaceutical compositions comprising these proteins or polynucleotides as well as methods of modifying an Htt gene using these compositions for treating or preventing Huntington's Disease.
    Type: Application
    Filed: November 16, 2020
    Publication date: March 4, 2021
    Inventors: Jeffrey C. Miller, Edward J. Rebar, H. Steve Zhang
  • Methods and compositions for treating Huntington's disease
    Patent number: 10857203
    Abstract: Disclosed herein are compositions comprising non-naturally occurring zinc finger domains, fusion proteins comprising these zinc finger domains, polynucleotides encoding these proteins, cells expressing these proteins and pharmaceutical compositions comprising these proteins or polynucleotides as well as methods of modifying an Htt gene using these compositions for treating or preventing Huntington's Disease.
    Type: Grant
    Filed: September 30, 2019
    Date of Patent: December 8, 2020
    Assignee: Sangamo Therapeutics, Inc.
    Inventors: Jeffrey C. Miller, Edward J. Rebar, H. Steve Zhang
  • Methods and compositions for treating trinucleotide repeat disorders
    Patent number: 10646543
    Abstract: Disclosed herein are methods and compositions for treating trinucleotide repeat disorders.
    Type: Grant
    Filed: March 9, 2018
    Date of Patent: May 12, 2020
    Assignee: Sangamo Therapeutics, Inc.
    Inventors: Philip D. Gregory, Edward J. Rebar, H. Steve Zhang
  • METHODS AND COMPOSITIONS FOR TREATING HUNTINGTON'S DISEASE
    Publication number: 20200030408
    Abstract: Disclosed herein are compositions comprising non-naturally occurring zinc finger domains, fusion proteins comprising these zinc finger domains, polynucleotides encoding these proteins, cells expressing these proteins and pharmaceutical compositions comprising these proteins or polynucleotides as well as methods of modifying an Htt gene using these compositions for treating or preventing Huntington's Disease.
    Type: Application
    Filed: September 30, 2019
    Publication date: January 30, 2020
    Inventors: Jeffrey C. Miller, Edward J. Rebar, H. Steve Zhang
  • HTT REPRESSORS AND USES THEREOF
    Publication number: 20200002390
    Abstract: Disclosed herein are Htt repressors and methods and compositions for use of these Htt repressors.
    Type: Application
    Filed: August 26, 2019
    Publication date: January 2, 2020
    Inventors: Steven Froelich, Jeffrey C. Miller, David Paschon, Edward J. Rebar, Bryan Zeitler, H. Steve Zhang
  • Methods and compositions for treating Huntington's disease
    Patent number: 10471123
    Abstract: Disclosed herein are compositions comprising non-naturally occurring zinc finger domains, fusion proteins comprising these zinc finger domains, polynucleotides encoding these proteins, cells expressing these proteins and pharmaceutical compositions comprising these proteins or polynucleotides as well as methods of modifying an Htt gene using these compositions for treating or preventing Huntington's Disease.
    Type: Grant
    Filed: March 4, 2019
    Date of Patent: November 12, 2019
    Assignee: Sangamo Therapeutics, Inc.
    Inventors: Jeffrey C. Miller, Edward J. Rebar, H. Steve Zhang
  • ZINC FINGER PROTEIN COMPOSITIONS FOR MODULATION OF HUNTINGTIN (HTT)
    Publication number: 20190322711
    Abstract: The present disclosure is in the field of modulation of Htt gene expression and HTT protein levels.
    Type: Application
    Filed: April 17, 2019
    Publication date: October 24, 2019
    Inventors: Steven Froelich, Ignacio Munoz-Sanjuan, Edward J. Rebar, Bryan Zeitler, H. Steve Zhang
  • HTT repressors and uses thereof
    Patent number: 10435441
    Abstract: Disclosed herein are Htt repressors and methods and compositions for use of these Htt repressors.
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: October 8, 2019
    Assignee: Sangamo Therapeutics, Inc.
    Inventors: Steven Froelich, Jeffrey C. Miller, David Paschon, Edward J. Rebar, Bryan Zeitler, H. Steve Zhang