Abstract: The present invention relates to novel compositions having improved stability during storage over extended periods of time. The compositions of the present invention comprise an active pharmaceutical ingredient combined with a synthetic form of magnesium aluminum silicate. The present invention also relates to novel compositions that comprise active pharmaceutical ingredients as tannate complexes combined with a synthetic form of magnesium aluminum silicate wherein the compositions have an increased weight percent of insoluble active pharmaceutical ingredient. The present invention also relates to a method for preparing the novel compositions.

Abstract: Compositions of tannate salts of phenylephrine and pyrilamine produced by a method that allows for the in-situ conversion and incorporation of the tannate salts in a single dosage form. The conversion process includes dissolving a salts of phenylephrine and pyrilamine in a solvent and mixing with a dispersing agent and tannic acid to generate tannate salts. The tannate salts may be further processed to single dosage forms, such as tablets and suspensions.

Abstract: Tannate compositions containing active pharmaceutical ingredients to be used for treating nausea, vomiting, pain, convulsions, and insomnia and manufacturing processes for preparing the tannate compositions.

Abstract: The present invention provides a novel tannate complex of hyoscyamine for human and veterinary pharmaceutical use. Tannate complexes of active pharmaceutical ingredients are used in sustained release applications and to improve certain organoleptic properties such as taste. A process for preparing the tannate complex of hyoscyamine is provided.

Abstract: A manufacturing process for tannate salt complexes of pharmaceutically active compounds includes the steps of dissolving a salt or free base of an active pharmaceutical ingredient in a pharmaceutically acceptable liquid in the presence of a dispersing agent and tannic acid to form a dispersion and combining the tannate salt complex of the active pharmaceutical ingredient without isolation or purification with pharmaceutically acceptable excipients to generate a therapeutic dosage form.

Abstract: The present invention relates generally to the field of tannate chemistry and more specifically to methods for processing tannate tablets, capsules, or other solid dosage forms. The present invention provides a novel manufacturing process for the conversion of one or more active pharmaceutical ingredients (“API”) into their tannate salt complexes while incorporating the complexes into a therapeutic solid-dosage form which also may include non-tannate API's. The first step of this process is to create a tannic acid powder blend by combining the salt or free base form of one or more APIs with tannic acid. After the dry blend is thoroughly mixed, a pharmaceutically acceptable liquid is added, for example by spraying, onto the dry powder blend facilitating the tannate salt conversion process. The conversion product is then added to additional dry powders thereby reducing the overall liquid content to a level that is more typical of wet granulation processes.

Abstract: A method of recycling wastepaper that is environmentally sustainable. A wastepaper stream is fractionated into a long fiber stream and a sludge stream. The sludge stream is combusted at vapor temperatures in excess of 1100° F. to create ash. Temperatures in excess of 1700° F. are used to more thoroughly eliminate environmentally harmful chemicals. The sizes of the particles in the ash are reduced and the ash is metered into the long fiber stream. New paper products may be produced using the combined long fiber and ash.

Abstract: Pharmaceutical compositions consisting of diphenhydramine tannate which are effective when administered for the symptomatic relief of sneezing, itchy, watery eyes, itchy nose or throat and runny nose due to hay fever (allergic rhinitis) or other respiratory allergies are disclosed.

Abstract: An active ingredient from the group of an antihistamine, a decongestant, an antitussive or anticholinergic is dissolved in a suitable solvent and added to a dispersion of tannic acid in water to form the tannate salt complex of the active ingredient. The active ingredient tannate salt complex without isolation or purification is then added to a liquid or semi-solid medium composed of thickening, suspending, coloring, sweetening and flavoring agents, with stirring. Thereafter, preservatives, pH-adjusting and anti-caking agents in a suitable solvent are mixed with the liquid or semi-solid medium to generate a therapeutic dosage form.