Abstract: The implantable scaffold matrix composition for osteogenic regeneration has a biodegradable polymer material selected from the group consisting of one or more of polylactic acid, polyglycolic acid, or polycaprolactone, or any combination thereof to provide a time release delivery of an osteogenic effect and further has a pharmaceutical composition selected from the group consisting of one or more of ibuprofen, non-steroidal anti-inflammatory drugs (NSAIDS), acetaminophen, or naproxen sodium or any combination thereof and wherein the implantable composition has a primary and a secondary time release. The primary time release being one of the polymer compositions; each time release extending occurring between 0 days and 19 days, both not being at 0 days.

Abstract: The implantable scaffold matrix composition for osteogenic regeneration has a biodegradable polymer material selected from the group consisting of one or more of polylactic acid, polyglycolic acid, or polycaprolactone, or any combination thereof to provide a time release delivery of an osteogenic effect and further has a pharmaceutical composition selected from the group consisting of one or more of ibuprofen, non-steroidal anti-inflammatory drugs (NSAIDS), acetaminophen, or naproxen sodium or any combination thereof and wherein the implantable composition has a primary and a secondary time release. The primary time release being one of the polymer compositions; each time release extending occurring between 0 days and 19 days, both not being at 0 days.

Abstract: Cruciate ligament substitutes are formed using fan-folded iliotibial band grafts of fascia lata. Devices of making the same and methods of making and using the same are described herein. The thick fan-folded grafts of fascia lata cruciate ligament substitutes disclosed herein are used in a single-loop fashion and have surprisingly exhibited load to failure and stiffness values that compare favorably with conventional grafts, including tibialis anterior, tibialis posterior, peroneus longus, and bone-patellar tendon-bone (BPTB) half-patella specimens, when the harvested iliotibial band grafts of fascia lata avoid portions thicker than 5 mm, or even 3 mm.

Abstract: Cruciate ligament substitutes are formed using fan-folded fascia lata grafts. Devices of making the same and methods of making and using the same are described herein. The fan-folded fascia lata cruciate ligament substitutes disclosed herein are used in a single-loop fashion and have surprisingly exhibited load to failure and stiffness values that compare favorably with conventional grafts, including tibialis anterior, tibialis posterior, peroneus longus, and bone-patellar tendon-bone (BPTB) half-patella specimens. It has been demonstrated that single-loop, fan-folded fascia lata sheets can exhibit mechanical properties that compare favorably with existing cruciate ligament grafts. An apparatus for handling a fascia lata sheet can include a first and a second removable anchoring member.

Abstract: An intervertebral implant for replacing a damage intervertebral disk within the spinal column can include a generally flat body having opposing surfaces. To promote bone growth and fusion of the adjacent vertebrae together, in an aspect, the implant can be provided with osteogenic or medicinal material received into one or more apertures disposed into the surfaces of the implant. To better retain the osteogenic material, the apertures can be disposed on a non-perpendicular angle with respect to the implant and/or can be tapered. In another aspect, the implant can include a plurality of grooves disposed across a surface to reduce slipping of the inserted implant between the adjacent vertebrae. In a further aspect, the implant can be formed by cutting a plurality of implants parallel along the diaphysis of a long bone. In another aspect, the implant can be generally as a bow or question mark.

Abstract: An invertebral implant for replacing a damage invertebral disk within the spinal column can include a generally flat body having opposing surfaces and peripheral wall or surface that extends between the opposing surface. Protruding outwardly from the peripheral wall can be a shelf-like flange that has a reduced thickness compared to the thickness of the main body of the implant. The flange provides an object or structure that the surgeon can grasp with forceps during insertion between adjacent vertebrae. Because the protruding nature and reduced thickness of the flange, both the flange and the forceps placed thereon can fit within or adjacent to the intervertebral space between the adjacent vertebrae without interfering with orientation or placement of the main body between the vertebrae. Hence, the flange may simplify the surgical insertion procedure.

Abstract: A particulate bone of defined sizes which has a unique property of direct bone osteoinduction without going through endochondral ossification stage is disclosed. The bone is not subjected to chemical extraction or decalcification. This allows for the retention of all physiologically active components of native bone. The invention hinges on the newly discovered ability of bone particles of defined sizes to exert osteoinduction by a pathway superior to and distinct from demineralized bone matrix and similar preparations.