Abstract: A method of detecting two different target molecules through a single electrode is carried out by (a) providing a conductive oxidation-reduction reaction detection electrode; (b) contacting a sample suspected of containing a first and second target molecule to the electrode under conditions in which the first and second target molecules are deposited on the electrode, wherein the first target molecule comprises a first label and the second target molecule comprises a second label; (c) contacting to the electrode a first transition metal complex that oxidizes the first preselected label in a first oxidation-reduction reaction and a second transition metal complex that oxidizes the first and second labels in a second oxidation-reduction reaction, with the first and second oxidation-reduction reactions producing different detectable signals; (d) detecting the presence of the first target molecule by detecting the first oxidation-reduction reaction; and(e) detecting the presence of the second target molecule by d

Abstract: Compositions of biomolecules such as nucleic acids that form molten salts are provided. These compositions molten compositions that have useful electrical properties. Such compositions include a salt of (i) an organic polymer ion such as a polynucleic acid anion, and (ii) a polyether or polysiloxane couterion. Methods of making and using such compositions, along with electrical devices such as memory devices, are also provided.

Abstract: The present invention relates to methods for synthesizing nucleic acids. The invention also relates to the production of an array of nucleic acids as well as methods for making such an array. Electrochemical methods may be used to both fabricate and interrogate the nucleic acid arrays.

Abstract: A method of detecting a nucleic acid (e.g., DNA, RNA) that contains at least one preselected base (e.g., adenine, guanine, 6-mercaptoguanine, 8-oxo-guanine, and 8-oxo-adenine) comprises (a) reacting the nucleic acid with a transition metal complex capable of oxidizing the preselected base in an oxidation-reduction reaction; (b) detecting the oxidation-reduction reaction; and (c) determining the presence or absence of the nucleic acid from the detected oxidation-reduction reaction at the preselected base. The method may be used in a variety of applications, including DNA sequencing, diagnostic assays, and quantitative analysis.

Abstract: The present invention concerns methods for the detection of a target nucleic acid sequence in a sample.