Patents by Inventor H. Volker Runzheimer

H. Volker Runzheimer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Gel particles having hapten moieties bound thereto as immunoassay reagent
    Patent number: 5045480
    Abstract: An immobilized hapten reagent for use in a specific binding assay for the determination of a hapten or binding analog thereof in a liquid test sample and methods for preparing and using the immobilized hapten reagent. The immobilized hapten reagent comprises a hapten moiety covalenty linked substantially only to the external surface of a gel particle. The immobilized hapten reagent is prepared by forming a reaction mixture comprising the hapten moiety and the carrier material in a nonswelling solvent wherein the gel particle is substantially impervious to the hapten moiety and wherein an analytically insignificant amount of the hapten moiety is nonspecifically bound to the gel particle. The immobilized hapten reagent is characterized by being substantially stable in aqueous solutions and exhibits an insignificant amount of leakage of the hapten moiety into a liquid test medium.
    Type: Grant
    Filed: February 9, 1989
    Date of Patent: September 3, 1991
    Assignee: Miles Inc.
    Inventors: Richard D. Johnson, H.-Volker Runzheimer, Ronald G. Sommer, Kin F. Yip
  • Polyacrylamide gel particles having hapten moieties bound thereto as immunoassay reagent
    Patent number: 4822747
    Abstract: An immobilized hapten reagent for use in a specific binding assay for the determination of a hapten or binding analog thereof in a liquid test sample and methods for preparing and using the immobilized hapten reagent. The immobilized hapten reagent comprises a hapten moiety covalently linked substantially only to the external surface of a polyacrylamide gel particle. The immobilized hapten reagent is prepared by forming a reaction mixture comprising the hapten moiety and the carrier material in a nonswelling solvent wherein the gel particle is substantially impervious to the hapten moiety and wherein an analytically insignificant amount of the hapten moiety is nonspecifically bound to the gel particle. The immobilized hapten reagent is characterized by being substantially stable in aqueous solutions and exhibits an insignificant amount of leakage of the hapten moiety into a liquid test medium.
    Type: Grant
    Filed: December 9, 1986
    Date of Patent: April 18, 1989
    Assignee: Miles Inc.
    Inventors: Richard D. Johnson, H. Volker Runzheimer, Ronald G. Sommer, Kin F. Yip