Abstract: The present disclosure provides modified immune cells or precursors thereof (e.g., gene edited modified T cells) comprising a modification in an endogenous gene locus encoding SOX and/or ID3. Methods for assessing and treating T cell dysfunction are also provided.

Abstract: A method of deploying a multibranch stent graft at a target site having a main lumen and a first branch lumen is provided. The method includes advancing a catheter including a main body having a first portion and a second portion, the main body defining a first portal being pre-cannulated with a first guide member, partially deploying the first portion of the main body, advancing a first sheath along the first guide member through the first portal, advancing a first articulatable wire through the first sheath, positioning the first articulatable wire into a first branch lumen of the target site, partially deploying the second portion of the main body, fully deploying the first portion and the second portion of the main body, advancing a first side branch body along the first articulatable wire into the first branch lumen, and deploying the first side branch body in the first branch lumen.

Abstract: The present disclosure provides anti-CCR4 chimeric antigen receptors (CARs) and compositions and methods for modified immune cells or precursors thereof (e.g., modified T cells) comprising anti-CCR4 CARs. Also provided are methods of using the anti-CCR4 CAR-expressing cells to treat cancer and T cell-depleting systems for use in combination with anti-CCR4 CAR T cell therapy.

Abstract: A nasal cannula for use with an ambient pressure gas dispensing system with ambient pressure tubing. Nasal prongs extend from a nasal cannula body. A gas reception aperture is in fluidic communication with an inner volume of the nasal cannula body for receiving gas through the tubing. A one-way expiratory valve is retained by the nasal cannula body. Gas provided by the tubing can be inhaled through the nasal prongs and expired breath can be discharged through the one-way expiratory valve. First and second FiO2 adjustment apertures are individually and selectively adjustable in size to provide a desired entrainment of atmospheric air with gas inhaled through the nasal prongs. The nasal cannula body is formed from a first body member of resilient and flexible material assembled with a cavity that receives a second body member of rigid material.

Abstract: A gas blending apparatus and an ambient pressure gas delivery and conservation system with such a gas blending apparatus for delivering gas at ambient pressure from a donor reservoir to a recipient. A main conduit body has a first port in fluidic communication with the donor reservoir and a second port for supplying gas to the recipient through ambient pressure tubing. A one-way inspiratory valve between the first port and the second port permits gas to be drawn from the reservoir but not to be received through the second port, through the first port, and into the donor reservoir. An air-input orifice permits ambient air to be blended with gas drawn from the reservoir. An orifice adjustment member is selectively repositionable relative to the air-input orifice to adjust the effective size of the aperture thereby to adjust the ratio of ambient air to gas drawn from the reservoir.

Abstract: This invention is related to the use of a volatile antimicrobial compound against pathogens. The volatile antimicrobial compounds provided include certain oxaborole compounds, for example benzoxaboroles. Delivery systems are provided to take advantage of the volatile nature of these antimicrobial compounds. The method and use disclosed can be combined with other volatile compounds.

Abstract: A jaw member for an end effector assembly of a vessel sealing instrument includes a seal plate assembly having first and second seal plates joined atop one another, the second seal plate defining a channel extending from a proximal to a distal end thereof. A thermal cutter assembly includes a substrate disposed within the channel which extends from the proximal to the distal end of the second seal plate. An insulator is disposed atop the substrate and is configured to extend therealong. A resistive element is disposed atop the insulator and is configured to generate heat upon activation thereof. An encapsulant is configured to electrically insulate the resistive element and thermally conduct heat from the resistive element, such that, upon activation thereof, tissue disposed within the end effector assembly is cut along the resistive element.

Abstract: Methods and apparatus according to which a first valve is opened, or kept open, the first valve being part of a wellhead including a flow component above the first valve. The method may further include detecting a state of the first valve and, in response to detecting the state of the first valve, metering an amount of grease to the first valve. In addition, or instead, the method may further include opening, or keeping open, a second valve, the second valve being operably coupled to the wellhead and positioned above the flow component, and, after opening, or keeping open, each of the first and second valves, detecting whether the second valve is open or closed, in response to detecting that the second valve is open, preventing the first valve from being closed, and in response to detecting that the second valve is closed, allowing the first valve to be closed.

Abstract: Aspects of the present disclosure relate to data visualization, and more specifically, to technology that automatically visualizes various analytics and predictions generated for mass participation endurance events, or other mass participation events of interest.

Abstract: A honey-based rooting gel composition and method of preparing the same are disclosed. The honey-based rooting gel composition comprises honey and symbiotic fungi such as Beauveria bassiana or Trichoderma koningii which increases plant growth and health, and may also contain a plant rooting hormone such as Indole-3-butyric acid (IBA) or other plant rooting hormones that promote root initiation, or natural rooting substances such as willow bark extracts that promote root growth. The use of honey provides an unexpected synergy to protect the cuttings from pathogens through the antibacterial and anti-fungal properties of the honey and benefits both plant and fungal growth by providing growth-promoting carbohydrates (mainly fructose and glucose) for both the plant and the germinating fungal spores.

Abstract: Described is a cotton surface nursing pad having both a proximal side and distal side. The proximal side is formed of a surface layer made of certified organic cotton, while the distal side is formed of a leakproof film later. Sandwiched between the surface layer and leakproof film layer are a first tissue layer, an absorbent core layer, and a second tissue layer. Notably, the absorbent core layer is formed of a combination of super absorbent polymer and fluff pulp, while the certified organic cotton is woven together using a half-cross pattern to form the surface layer.

Abstract: Aspects of the present disclosure relate to data visualization, and more specifically, to technology that automatically visualizes various analytics and predictions generated for mass participation endurance events, or other mass participation events of interest.

Abstract: Methods and apparatus according to which a first valve is opened, or kept open, the first valve being part of a wellhead including a flow component above the first valve. The method may further include detecting a state of the first valve and, in response to detecting the state of the first valve, metering an amount of grease to the first valve. In addition, or instead, the method may further include opening, or keeping open, a second valve, the second valve being operably coupled to the wellhead and positioned above the flow component, and, after opening, or keeping open, each of the first and second valves, detecting whether the second valve is open or closed, in response to detecting that the second valve is open, preventing the first valve from being closed, and in response to detecting that the second valve is closed, allowing the first valve to be closed.

Abstract: A moisture curable, non-bitumen based and non-asphaltic based adhesive includes an extender, a compatibilizer, and a polymer, wherein the polymer includes reactive silyl groups.

Abstract: A moisture curable, non-bitumen based and non-asphaltic based adhesive includes an extender, a compatibilizer, and a polymer, wherein the polymer includes reactive silyl groups.

Abstract: A honey-based rooting gel composition and method of preparing the same are disclosed. The honey-based rooting gel composition comprises honey and symbiotic fungi such as Beauveria bassiana or Trichoderma koningii which increases plant growth and health, and may also contain a plant rooting hormone such as Indole-3-butyric acid (IBA) or other plant rooting hormones that promote root initiation, or natural rooting substances such as willow bark extracts that promote root growth. The use of honey provides an unexpected synergy to protect the cuttings from pathogens through the antibacterial and anti-fungal properties of the honey and benefits both plant and fungal growth by providing growth-promoting carbohydrates (mainly fructose and glucose) for both the plant and the germinating fungal spores.

Abstract: A cloud-based application generates food product recommendations in support of medical nutritional therapy. The recommendations are calculated based on at least one patient-specific nutritional prescription and extended ingredient data that identifies food product ingredients or nutritional calculations that do not appear on packaging labels. The patient-specific nutritional prescription is calculated based on a patient profile and at least one nutritional prescription template. The recommendations may be used to perform a pantry makeover in which harmful food products are removed from household food storage and beneficial food products are added to household food storage. Recommendations may be calculated in real-time for food products that are identified during food shopping. Less harmful alternative food products are identified and suggested.

Abstract: This invention is related to the use of a volatile antimicrobial compound against pathogens. The volatile antimicrobial compounds provided include certain oxaborole compounds, for example benzoxaboroles. Delivery systems are provided to take advantage of the volatile nature of these antimicrobial compounds. The method and use disclosed can be combined with other volatile compounds.

Abstract: Aspects of the present disclosure relate to data visualization, and more specifically, to technology that automatically visualizes various analytics and predictions generated for mass participation endurance events, or other mass participation events of interest.