Patents by Inventor Ha Do
Ha Do has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240140986Abstract: Disclosed herein are compounds of Formula (I-A), wherein the vari-ables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used as antioxidant inflammation modulators. In some aspects, the present disclosure provides methods wherein the compounds and composition described herein are used for the treatment of diseases and disorders associated with inflammation and cancer.Type: ApplicationFiled: January 18, 2022Publication date: May 2, 2024Inventors: Xin JIANG, Ha DO, Haizhou SUN, Melean VISNICK, Robert M. KRAL, JR.
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Publication number: 20240069100Abstract: Designs of thermo-hygrostat devices capable of uniformly maintain temperature and humidity inside a chamber are disclosed. One example of such a device can include, among others, a chamber in which a sample is accommodated and internal temperature and humidity can be controlled; a lower duct provided on a first side of the chamber and sending a fluid inside the chamber to an outside of the chamber; a temperature and humidity control portion provided on the lower duct and controlling temperature and humidity of a fluid received from the lower duct.Type: ApplicationFiled: August 25, 2023Publication date: February 29, 2024Inventors: Jeong Hwan LEE, Ji Seok LEE, Yu Geun KWON, Hye Lim DO, Seok Ha PARK, Hyeon Seok CHA
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Publication number: 20230111914Abstract: In some aspects, the present disclosure provides compounds of the formula: (I) and (II), wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used as antioxidant inflammation modulators. In some aspects, the present disclosure provides methods wherein the compounds and composition described herein are used for the treatment of diseases and disorders associated with inflammation and cancer.Type: ApplicationFiled: December 18, 2020Publication date: April 13, 2023Inventors: Christopher F. BENDER, Ha DO, Xin JIANG, Haizhou SUN, Melean VISNICK, Ingo JANSER, Lloyd J. SIMONS, Heinrich J. SCHOSTAREZ
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Publication number: 20220098568Abstract: The present invention provides histidyl-tRNA synthetase and Fc region conjugate polypeptides (HRS-Fc conjugates), such as HRS-Fc fusion polypeptides, compositions comprising the same, and methods of using such conjugates and compositions for treating or diagnosing a variety of conditions. The HRS-Fc conjugates of the invention have improved controlled release properties, stability, half-life, and other pharmacokinetic and biological properties relative to corresponding, unmodified HRS polypeptides.Type: ApplicationFiled: June 10, 2021Publication date: March 31, 2022Inventors: Chi-Fang WU, Darin LEE, Jeffry D. WATKINS, Kristi PIEHL, Kyle CHIANG, Marc THOMAS, Minh-Ha DO, Ying BUECHLER, John D. MENDLEIN
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Patent number: 11072787Abstract: The present invention provides histidyl-tRNA synthetase and Fc region conjugate polypeptides (HRS-Fc conjugates), such as HRS-Fc fusion polypeptides, compositions comprising the same, and methods of using such conjugates and compositions for treating or diagnosing a variety of conditions. The HRS-Fc conjugates of the invention have improved controlled release properties, stability, half-life, and other pharmacokinetic and biological properties relative to corresponding, unmodified HRS polypeptides.Type: GrantFiled: April 7, 2020Date of Patent: July 27, 2021Assignee: aTyr Pharma Inc.Inventors: Chi-Fang Wu, Darin Lee, Jeffry D. Watkins, Kristi Piehl, Kyle P. Chiang, Marc Thomas, Minh-Ha Do, Ying Buechler, John D. Mendlein
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Publication number: 20210040142Abstract: Disclosed herein are compounds of the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used as antioxidant inflammation modulators. In some aspects, the present disclosure provides methods wherein the compounds and composition described herein are used for the treatment of diseases and disorders, including those associated with inflammation and cancer.Type: ApplicationFiled: July 20, 2020Publication date: February 11, 2021Applicant: REATA PHARMACEUTICALS, INC.Inventors: Xin JIANG, Christopher F. BENDER, Ha DO, Haizhou SUN, Melean VISNICK
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Publication number: 20200283751Abstract: The present invention provides histidyl-tRNA synthetase and Fc region conjugate polypeptides (HRS-Fc conjugates), such as HRS-Fc fusion polypeptides, compositions comprising the same, and methods of using such conjugates and compositions for treating or diagnosing a variety of conditions. The HRS-Fc conjugates of the invention have improved controlled release properties, stability, half-life, and other pharmacokinetic and biological properties relative to corresponding, unmodified HRS polypeptides.Type: ApplicationFiled: April 7, 2020Publication date: September 10, 2020Inventors: Chi-Fang WU, Darin LEE, Jeffry D. WATKINS, Kristi PIEHL, Kyle P. CHIANG, Marc THOMAS, Minh-Ha DO, Ying BUECHLER, John D. MENDLEIN
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Patent number: 10711260Abstract: The present invention provides histidyl-tRNA synthetase and Fc region conjugate polypeptides (HRS-Fc conjugates), such as HRS-Fc fusion polypeptides, compositions comprising the same, and methods of using such conjugates and compositions for treating or diagnosing a variety of conditions. The HRS-Fc conjugates of the invention have improved controlled release properties, stability, half-life, and other pharmacokinetic and biological properties relative to corresponding, unmodified HRS polypeptides.Type: GrantFiled: September 20, 2019Date of Patent: July 14, 2020Assignee: aTyr Pharma, Inc.Inventors: Chi-Fang Wu, Darin Lee, Jeffry D. Watkins, Kristi Piehl, Kyle P. Chiang, Marc Thomas, Minh-Ha Do, Ying Buechler, John D. Mendlein
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Publication number: 20200149028Abstract: The present invention provides histidyl-tRNA synthetase and Fc region conjugate polypeptides (HRS-Fc conjugates), such as HRS-Fc fusion polypeptides, compositions comprising the same, and methods of using such conjugates and compositions for treating or diagnosing a variety of conditions. The HRS-Fc conjugates of the invention have improved controlled release properties, stability, half-life, and other pharmacokinetic and biological properties relative to corresponding, unmodified HRS polypeptides.Type: ApplicationFiled: September 20, 2019Publication date: May 14, 2020Inventors: Chi-Fang WU, Darin Lee, Jeffry D. Watkins, Kristi Piehl, Kyle P. Chiang, Marc Thomas, Minh-Ha Do, Ying Buechler, John D. Mendlein
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Patent number: 10472618Abstract: The present invention provides histidyl-tRNA synthetase and Fc region conjugate polypeptides (HRS-Fc conjugates), such as HRS-Fc fusion polypeptides, compositions comprising the same, and methods of using such conjugates and compositions for treating or diagnosing a variety of conditions. The HRS-Fc conjugates of the invention have improved controlled release properties, stability, half-life, and other pharmacokinetic and biological properties relative to corresponding, unmodified HRS polypeptides.Type: GrantFiled: September 5, 2018Date of Patent: November 12, 2019Assignees: aTyr Pharma, Inc., Pangu Biopharma LimitedInventors: Chi-Fang Wu, Darin Lee, Jeffry D. Watkins, Kristi Piehl, Kyle P. Chiang, Marc Thomas, Minh-Ha Do, Ying Buechler, John D. Mendlein
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Publication number: 20190062720Abstract: The present invention provides histidyl-tRNA synthetase and Fc region conjugate polypeptides (HRS-Fc conjugates), such as HRS-Fc fusion polypeptides, compositions comprising the same, and methods of using such conjugates and compositions for treating or diagnosing a variety of conditions. The HRS-Fc conjugates of the invention have improved controlled release properties, stability, half-life, and other pharmacokinetic and biological properties relative to corresponding, unmodified HRS polypeptides.Type: ApplicationFiled: September 5, 2018Publication date: February 28, 2019Inventors: Chi-Fang WU, Darin Lee, Jeffry D. Watkins, Kristi Piehl, Kyle P. Chiang, Marc Thomas, Minh-Ha Do, Ying Buechler, John D. Mendlein
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Patent number: 10198522Abstract: A system and method for creating an index of native application content indexable by a search engine is disclosed herein. The system includes a content server, a web server, and a URL to native mobile application mapping database comprising a plurality of web content and a plurality of native mobile application content. The content server is configured to serve up the content as both a native mobile application and a web based application.Type: GrantFiled: April 12, 2015Date of Patent: February 5, 2019Assignee: Joingo, LLCInventors: Stephen S. Boyle, Russell S. Greer, Thang Dao, Ha Do
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Patent number: 10093915Abstract: The present invention provides histidyl-tRNA synthetase and Fc region conjugate polypeptides (HRS-Fc conjugates), such as HRS-Fc fusion polypeptides, compositions comprising the same, and methods of using such conjugates and compositions for treating or diagnosing a variety of conditions. The HRS-Fc conjugates of the invention have improved controlled release properties, stability, half-life, and other pharmacokinetic and biological properties relative to corresponding, unmodified HRS polypeptides.Type: GrantFiled: January 25, 2017Date of Patent: October 9, 2018Assignee: aTyr Pharma Inc.Inventors: Chi-Fang Wu, Darin Lee, Jeffry D. Watkins, Kristi Piehl, Kyle P. Chiang, Marc Thomas, Minh-Ha Do, Ying Buechler, John D. Mendlein
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Publication number: 20170267990Abstract: The present invention provides histidyl-tRNA synthetase and Fc region conjugate polypeptides (HRS-Fc conjugates), such as HRS-Fc fusion polypeptides, compositions comprising the same, and methods of using such conjugates and compositions for treating or diagnosing a variety of conditions. The HRS-Fc conjugates of the invention have improved controlled release properties, stability, half-life, and other pharmacokinetic and biological properties relative to corresponding, unmodified HRS polypeptides.Type: ApplicationFiled: January 25, 2017Publication date: September 21, 2017Inventors: Chi-Fang Wu, Darin Lee, Jeffry D. Watkins, Kristi Piehl, Kyle P. Chiang, Marc Thomas, Minh-Ha Do, Ying Buechler, John D. Mendlein
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Patent number: 9714419Abstract: The present invention provides PEGylated tyrosyl-tRNA synthetase (YRS) polypeptides, compositions comprising the same, and methods of using such polypeptides and compositions for treating or diagnosing a variety of conditions. The PEGylated YRS polypeptides of the invention have improved controlled release properties, stability, half-life, and other pharmacokinetic properties compared to non-PEGylated YRS polypeptides.Type: GrantFiled: August 8, 2012Date of Patent: July 25, 2017Assignee: aTyr Pharma, Inc.Inventors: Jeffrey D. Watkins, Ying Ji Buechler, Chi-Fang Wu, Minh-Ha Do, Alain P. Vasserot, John D. Mendlein
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Patent number: 9587235Abstract: The present invention provides histidyl-tRNA synthetase and Fc region conjugate polypeptides (HRS-Fc conjugates), such as HRS-Fc fusion polypeptides, compositions comprising the same, and methods of using such conjugates and compositions for treating or diagnosing a variety of conditions. The HRS-Fc conjugates of the invention have improved controlled release properties, stability, half-life, and other pharmacokinetic and biological properties relative to corresponding, unmodified HRS polypeptides.Type: GrantFiled: March 14, 2014Date of Patent: March 7, 2017Assignee: aTyr Pharma, Inc.Inventors: Ying Buechler, Kyle Chiang, Minh-Ha Do, Darin Lee, Kristi Piehl, Marc Thomas, Jeffry D. Watkins, Chi-Fang Wu, John D. Mendlein
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Publication number: 20140349369Abstract: The present invention provides histidyl-tRNA synthetase and Fc region conjugate polypeptides (HRS-Fc conjugates), such as HRS-Fc fusion polypeptides, compositions comprising the same, and methods of using such conjugates and compositions for treating or diagnosing a variety of conditions. The HRS-Fc conjugates of the invention have improved controlled release properties, stability, half-life, and other pharmacokinetic and biological properties relative to corresponding, unmodified HRS polypeptides.Type: ApplicationFiled: March 14, 2014Publication date: November 27, 2014Inventors: Ying Buechler, Kyle Chiang, Minh-Ha Do, Darin Lee, Kristi Piehl, Marc Thomas, Jeffry D. Watkins, Chi-Fang Wu, John D. Mendlein
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Publication number: 20140255378Abstract: The present invention provides PEGylated tyrosyl-tRNA synthetase (YRS) polypeptides, compositions comprising the same, and methods of using such polypeptides and compositions for treating or diagnosing a variety of conditions. The PEGylated YRS polypeptides of the invention have improved controlled release properties, stability, half-life, and other pharmacokinetic properties compared to non-PEGylated YRS polypeptides.Type: ApplicationFiled: August 8, 2012Publication date: September 11, 2014Applicant: aTyr Pharma, IncInventors: Jeffrey D. Watkins, Ying Ji Buechler, Chi-Fang Wu, Minh-Ha Do, Alain P. Vasserot, John D. Mendlein
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Patent number: 7860167Abstract: An efficient and non-iterative 3D post processing method and system is proposed for mosquito noise reduction, block localization and correction in DCT block-based decoded images. The 3D post processing is based on a simple classification that segments a picture in multiple regions such as Edge, Near Edge, Flat, Near Flat and Texture regions. The proposed technique comprises also an efficient and shape adaptive local power estimation for equivalent additive noise and provides simple noise power weighting for each above cited region. Temporal filtering configurations using Minimum Noise Variance Criterion are proposed for reducing temporally varying coding artifacts. A Minimum Mean Square Error or Minimum Mean Square Error-like noise reduction with robust and effective shape adaptive windowing is utilized for smoothing mosquito and/or random noise for the whole image, particularly for Edge regions.Type: GrantFiled: July 29, 2005Date of Patent: December 28, 2010Assignee: Algolith Inc.Inventors: Chon Tam Le Dinh, Ha Do Viet, Ngoc Lan Nguyen, Duong Tuan Nguyen, Thi Thanh Hien Nguyen
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Patent number: 6633683Abstract: The basic configuration of Single local Adaptive Window Spatial Noise Reducer (SAW-SNR) is based on a preliminary de-noising low-pass filter followed by homogenous region segmentation to the considered pixel in a given local window. The configuration is composed also of an adaptive local mean estimator, an adaptive local statistic estimator which is preferably an economic standard deviation (SD) estimator and finally, a minimum-mean-square-error (MMSE) based de-noising technique. The proposed segmentation configuration outperforms existing spatial noise reducers in term of subjective and objective performances, in term of edge preservation, noise reduction in both homogenous regions or picture edges and Peak Signal to noise Ratio (PSNR). A second configuration in the form of a Parallel Multiple local Adaptive Window Spatial Noise Reducer (Parallel M-AW-SNR), is a combination of several basic configurations which implements different segmented windows.Type: GrantFiled: June 26, 2000Date of Patent: October 14, 2003Assignee: Miranda Technologies Inc.Inventors: Chon Tam Le Dinh, Cong Toai Kieu, Ha Do Viet