Abstract: The present invention provides a novel compound having a protein kinase inhibition activity, a stereoisomer thereof or a pharmaceutically acceptable salt thereof. The compound, the stereoisomer thereof or the pharmaceutically acceptable salt thereof according to the present invention show a protein kinase inhibition activity, thus being effective in preventing or treating diseases related to protein kinase, such as cancer, autoimmune disease, neurological disease, metabolic disease, infection or the like.

Abstract: The present invention provides a novel compound having a protein kinase inhibition activity, a stereoisomer thereof or a pharmaceutically acceptable salt thereof. The compound, the stereoisomer thereof or the pharmaceutically acceptable salt thereof according to the present invention show a protein kinase inhibition activity, thus being effective in preventing or treating diseases related to protein kinase, such as cancer, autoimmune disease, neurological disease, metabolic disease, infection or the like.

Abstract: Disclosed is a pharmaceutical composition, comprising: a) at least one sorbitan unsaturated fatty acid ester having a polar head with at least two or more —OH (hydroxyl) groups; b) at least one phospholipid; c) at least one liquid crystal hardener which is free of an ionizable group and has a triacyl group with 15 to 40 carbon atoms or a carbon ring structure in a hydrophobic moiety; and d) at least one GnRH (gonadotropin-releasing hormone) analogue as a pharmacologically active substance, wherein said lipid pre-concentrate exists as a liquid phase in absence of aqueous fluid and forms into a liquid crystal in presence of aqueous fluid. The pharmaceutical composition is configured to enhance the sustained release of the pharmacologically active substance GnRH analogue.

Abstract: The present invention is related to a corner panel of an LNG cargo that includes a main body, which constitutes a corner area of the cargo, and a stress diverging part, which reduces the convergence of stress of the main body by being integrated with an internal face of the main body and being formed with curvature. Therefore, by forming the corner area of the LNG cargo in a single body having a round-shaped curvature, convergence of stress caused by the deformation of the hull and thermal deformation can be prevented, and possibility of crack in a secondary barrier can be removed. By allowing the secondary barrier to be formed in a curved shape, the constructability of the secondary barrier can be greatly improved. Since no hardwood key or plywood is required, the thickness of a primary barrier can be reduced as the stress is decreased and the reliability of the secondary barrier is improved, and the weight can be greatly reduced over the conventional cargo corner area.

Abstract: The present invention is related to a reinforcing member for a membrane for improving the pressure-withstanding property of the membrane having corrugations, and a membrane assembly having the reinforcing member and a method of constructing the membrane assembly. By providing a reinforcing member for a membrane having corrugations and installed in an insulating structural member of an LNG cargo, the present invention can prevent the collapse of the corrugation and attenuate shocks against a same load without increasing the facial rigidity of the corrugation, and improve the insulating property by forming an additional insulating layer.

Abstract: The present invention is related to a reinforcing member for a membrane for improving the pressure-withstanding property of the membrane having corrugations, and a membrane assembly having the reinforcing member and a method of constructing the membrane assembly. By providing a reinforcing member for a membrane having corrugations and installed in an insulating structural member of an LNG cargo, the present invention can prevent the collapse of the corrugation and attenuate shocks against a same load without increasing the facial rigidity of the corrugation, and improve the insulating property by forming an additional insulating layer.

Abstract: Provided is a continuous circulation sand filter including a filtering barrel filled with a sand filtering layer, an inflow tube for introducing raw water into the filtering barrel, a treated water discharge part for discharging treated water purified by passing the raw water through the sand filtering layer from a lower end of the sand filtering layer to an upper end thereof, an air lift tube for transferring contaminated sand, located in the lower end of the sand filtering layer, from a lower part of the filtering barrel to an upper part thereof, a transfer water discharge filter contacting the air lift tube to discharge transfer water moved upward together with sand through the air lift tube and trap the sand and a foreign substance, a descent guide tube downwardly moving the sand and the foreign substance moved to the upper part of the filtering barrel through the air lift tube, and a foreign substance separation tube suctioning the downwardly moving foreign substance to remove the foreign substance from

Abstract: The present invention is related to a corner panel of an LNG cargo that includes a main body, which constitutes a corner area of the cargo, and a stress diverging part, which reduces the convergence of stress of the main body by being integrated with an internal face of the main body and being formed with curvature. Therefore, by forming the corner area of the LNG cargo in a single body having a round-shaped curvature, convergence of stress caused by the deformation of the hull and thermal deformation can be prevented, and possibility of crack in a secondary barrier can be removed. By allowing the secondary barrier to be formed in a curved shape, the constructability of the secondary barrier can be greatly improved. Since no hardwood key or plywood is required, the thickness of a primary barrier can be reduced as the stress is decreased and the reliability of the secondary barrier is improved, and the weight can be greatly reduced over the conventional cargo corner area.

Abstract: The present invention provides a method for manufacturing a composite separator for a polymer electrolyte membrane fuel cell. The method comprises: preparing a prepreg as a continuous carbon fiber-reinforced composite and a graphite foil; allowing the cut prepreg and graphite foil to pass through a stacking/compression roller to be compressed; allowing the prepreg in which the graphite foil is integrally stacked to be heated and pressed by a hot press such that hydrogen, air, and coolant flow fields are formed or to pass through a hot roller to be formed into a separator; removing unnecessary portions from the heated and pressed separator using a trim cutter; and post-curing the thus formed separator, wherein the graphite foil may be stacked on the prepreg as the continuous carbon fiber-reinforced composite such that a graphite layer is integrally formed with the prepreg.

Abstract: Disclosed is a pharmaceutical composition, comprising: a) at least one sorbitan unsaturated fatty acid ester having a polar head with at least two or more —OH (hydroxyl) groups; b) at least one phospholipid; c) at least one liquid crystal hardener which is free of an ionizable group and has a triacyl group with 15 to 40 carbon atoms or a carbon ring structure in a hydrophobic moiety; and d) at least one GnRH (gonadotropin-releasing hormone) analogue as a pharmacologically active substance, wherein said lipid pre-concentrate exists as a liquid phase in absence of aqueous fluid and forms into a liquid crystal in presence of aqueous fluid. The pharmaceutical composition is configured to enhance the sustained release of the pharmacologically active substance GnRH analogue.

Abstract: The present invention provides a composite separator for a polymer electrolyte membrane fuel cell (PEMFC) and a method for manufacturing the same. The inventive method involves allowing graphite foil layers to be brought into direct contact with each other when graphite foils are stacked on both sides of a carbon fiber reinforced composite material prepreg, thereby improving electrical conductivity in the thickness direction of the separator.

Abstract: Disclosed is a sustained-release lipid pre-concentrate, comprising: a) at least one liquid crystal former; b) at least one neutral phospholipid; c) at least one liquid crystal hardener; and d) at least one anionic anchoring agent, wherein the sustained-release pre-concentrate exists as a lipid liquid phase in the absence of aqueous fluid and forms into a liquid crystal upon exposure to aqueous fluid. The sustained-release lipid pre-concentrate is configured to enhance the sustained release of cationic pharmacologically active substance through ionic interaction between the anionic anchoring agent and the cationic pharmacologically active substance.

Abstract: The present invention provides a composite separator for a polymer electrolyte membrane fuel cell (PEMFC) and a method for manufacturing the same, in which a graphite foil prepared by compressing expanded graphite is stacked on a carbon fiber-reinforced composite prepreg or a mixed solution prepared by mixing graphite flake and powder with a resin solvent is applied to the cured composite prepreg such that a graphite layer is integrally molded on the outermost end of the separator.

Abstract: The present invention is related to a reinforcing member for a membrane for improving the pressure-withstanding property of the membrane having corrugations, and a membrane assembly having the reinforcing member and a method of constructing the membrane assembly. By providing a reinforcing member for a membrane having corrugations and installed in an insulating structural member of an LNG cargo, the present invention can prevent the collapse of the corrugation and attenuate shocks against a same load without increasing the facial rigidity of the corrugation, and improve the insulating property by forming an additional insulating layer.

Abstract: An insulation structure of a cargo tank in an LNG carrier and a method of constructing the insulation structure include a first metal foil attached and installed in between the top insulation panel and the bottom insulation panel, a second metal foil attached to and installed on the first metal foil that is positioned on an upper side of a gap formed between the bottom insulation panels, and a top bridge panel attached to and installed on an upper side of the second metal foil.

Abstract: The present invention provides a composite separator for a polymer electrolyte membrane fuel cell (PEMFC) and a method for manufacturing the same, in which a graphite foil prepared by compressing expanded graphite is stacked on a carbon fiber-reinforced composite prepreg or a mixed solution prepared by mixing graphite flake and powder with a resin solvent is applied to the cured composite prepreg such that a graphite layer is integrally molded on the outermost end of the separator.

Abstract: The present invention provides a composite separator for a polymer electrolyte membrane fuel cell (PEMFC) and a method for manufacturing the same. The inventive method involves allowing graphite foil layers to be brought into direct contact with each other when graphite foils are stacked on both sides of a carbon fiber reinforced composite material prepreg, thereby improving electrical conductivity in the thickness direction of the separator.

Abstract: The present invention provides a method for manufacturing a composite separator for a fuel cell, which can reduce the electrical contact resistance by performing an additional post-treatment to remove residual resin remaining on the surface of the composite separator by plasma etching. In certain preferred embodiments, the present invention provides a method for manufacturing a composite separator for a fuel cell, in which a liquid phase resin for gasket is applied to the surface of the composite separator along a predetermined gasket pattern, or a semi-cured resin for gasket in the form of a film with a predetermined gasket pattern is stacked on the surface of the composite separator, and then plasma etching is performed to remove the residual resin and, at the same time, cure the resin for gasket, thus reducing the overall processing time to improve the productivity and preventing a composite material of the separator from being damaged.

Abstract: A fixing apparatus for fixing a cargo insulation panel to a hull is provided. The fixing apparatus includes a fixing plate adhered to one face of the insulation panel, a plurality of fixing brackets protruded to the outside of the fixing plate, protruded portions of the fixing brackets being fixed by stud bolts arranged on the hull, and a coupling device configured to couple the fixing brackets to the fixing plate.

Abstract: Provided is a continuous circulation sand filter including a filtering barrel filled with a sand filtering layer, an inflow tube for introducing raw water into the filtering barrel, a treated water discharge part for discharging treated water purified by passing the raw water through the sand filtering layer from a lower end of the sand filtering layer to an upper end thereof, an air lift tube for transferring contaminated sand, located in the lower end of the sand filtering layer, from a lower part of the filtering barrel to an upper part thereof, a transfer water discharge filter contacting the air lift tube to discharge transfer water moved upward together with sand through the air lift tube and trap the sand and a foreign substance, a descent guide tube downwardly moving the sand and the foreign substance moved to the upper part of the filtering barrel through the air lift tube, and a foreign substance separation tube suctioning the downwardly moving foreign substance to remove the foreign substance from