Patents by Inventor Hadas Sara HERSHKOVICH
Hadas Sara HERSHKOVICH has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11964146Abstract: Tumors in portions of a subject's body that have a longitudinal axis (e.g., the torso, head, and arm) can be treated with TTFields by affixing first and second sets of electrodes at respective positions that are longitudinally prior to and subsequent to a target region. An AC voltage with a frequency of 100-500 kHz is applied between these sets of electrodes. This imposes an AC electric field with field lines that run through the target region longitudinally. The field strength is at least 1 V/cm in at least a portion of the target region. In some embodiments, this approach is combined with the application of AC electric fields through the target region in a lateral direction (e.g., front to back and/or side to side) in order to apply AC electric fields with different orientations to the target region.Type: GrantFiled: August 11, 2022Date of Patent: April 23, 2024Assignee: Novocure GmbHInventors: Eilon Kirson, Yoram Wasserman, Hadas Sara Hershkovich, Zeev Bomzon
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Patent number: 11911612Abstract: The planning of treatment using tumor treating fields (TTFields) in a portion of a subject's body (e.g., the subject's head) can be improved by obtaining an image of the body portion, and generating, based on the image, a 3D model of electrical conductivity. A target volume within the 3D model is identified, and a set of model electrodes is added to the 3D model at given locations. Then, for each voxel in the target volume, the power loss density (PLD) that will be present when TTFields are eventually applied is determined. The same process is repeated for a plurality of different electrode locations. Finally, the set of electrode locations that yielded the best PLD is selected, and a description of those locations is output.Type: GrantFiled: July 18, 2019Date of Patent: February 27, 2024Assignee: Novocure GmbHInventors: Zeev Bomzon, Hadas Sara Hershkovich, Noa Urman, Ariel Naveh, Shay Levi
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Publication number: 20240061398Abstract: Methods, systems, and apparatuses are described for guiding placement of transducer arrays on a patient.Type: ApplicationFiled: October 7, 2020Publication date: February 22, 2024Applicant: Novocure GmbHInventor: Hadas Sara HERSHKOVICH
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Publication number: 20240001115Abstract: Tumor treating fields (TTFields) can be delivered by implanting a plurality of sets of implantable electrode elements within a person's body. Temperature sensors positioned to measure the temperature at the electrode elements are also implanted, along with a circuit that collects temperature measurements from the temperature sensors. In some embodiments, an AC voltage generator configured to apply an AC voltage across the plurality of sets of electrode elements is also implanted within the person's body.Type: ApplicationFiled: September 15, 2023Publication date: January 4, 2024Applicant: Novocure GmbHInventors: Yoram WASSERMAN, Zeev BOMZON, Hadas Sara HERSHKOVICH, Ariel NAVEH, Moshe GILADI, Eilon KIRSON, Golan BAR-TAL, Tali VOLOSHIN-SELA
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Patent number: 11857782Abstract: Tumor treating fields (TTFields) can be delivered by implanting a plurality of sets of implantable electrode elements within a person's body. Temperature sensors positioned to measure the temperature at the electrode elements are also implanted, along with a circuit that collects temperature measurements from the temperature sensors. In some embodiments, an AC voltage generator configured to apply an AC voltage across the plurality of sets of electrode elements is also implanted within the person's body.Type: GrantFiled: February 14, 2023Date of Patent: January 2, 2024Assignee: Novocure GmbHInventors: Yoram Wasserman, Zeev Bomzon, Hadas Sara Hershkovich, Ariel Naveh, Moshe Giladi, Eilon Kirson, Golan Bar-Tal, Tali Voloshin-Sela
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Publication number: 20230206548Abstract: Methods, systems, and apparatuses are described for managing placement of transducer arrays on a subject/patient.Type: ApplicationFiled: March 2, 2023Publication date: June 29, 2023Applicant: Novocure GmbHInventors: Hadas Sara HERSHKOVICH, Zeev BOMZON, Gil ZIGELMAN, Shira LUK-ZILBERMAN, Ori Kook, Oren Ben Zion BAKALO
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Publication number: 20230191123Abstract: Tumor treating fields (TTFields) can be delivered by implanting a plurality of sets of implantable electrode elements within a person’s body. Temperature sensors positioned to measure the temperature at the electrode elements are also implanted, along with a circuit that collects temperature measurements from the temperature sensors. In some embodiments, an AC voltage generator configured to apply an AC voltage across the plurality of sets of electrode elements is also implanted within the person’s body.Type: ApplicationFiled: February 14, 2023Publication date: June 22, 2023Applicant: Novocure GmbHInventors: Yoram WASSERMAN, Zeev BOMZON, Hadas Sara HERSHKOVICH, Ariel NAVEH, Moshe GILADI, Eilon KIRSON, Golan BAR-TAL, Tali VOLOSHIN-SELA
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Patent number: 11650277Abstract: A 3D model of AC electrical conductivity (at a given frequency) of an anatomic volume can be created by obtaining two MRI images of the anatomic volume, where the two images have different repetition times. Then, for each voxel in the anatomic volume, a ratio IR of the intensity of the corresponding voxels in the two MRI images is calculated. This calculated IR is then mapped into a corresponding voxel of a 3D model of AC electrical conductivity at the given frequency. The given frequency is below 1 MHz (e.g., 200 kHz). In some embodiments, the 3D model of AC electrical conductivity at the given frequency is used to determine the positions for the electrodes in TTFields (Tumor Treating Fields) treatment.Type: GrantFiled: April 9, 2019Date of Patent: May 16, 2023Assignee: Novocure GmbHInventors: Cornelia Wenger, Catherine Tempel-Brami, Hadas Sara Hershkovich, Moshe Giladi, Zeev Bomzon
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Patent number: 11620789Abstract: Methods, systems, and apparatuses are described for managing placement of transducer arrays on a subject/patient.Type: GrantFiled: May 4, 2020Date of Patent: April 4, 2023Assignee: Novocure GmbHInventors: Hadas Sara Hershkovich, Zeev Bomzon, Gil Zigelman, Shira Luk-Zilberman, Ori Kook, Oren Ben Zion Bakalo
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Patent number: 11607543Abstract: Tumor treating fields (TTFields) can be delivered by implanting a plurality of sets of implantable electrode elements within a person's body. Temperature sensors positioned to measure the temperature at the electrode elements are also implanted, along with a circuit that collects temperature measurements from the temperature sensors. In some embodiments, an AC voltage generator configured to apply an AC voltage across the plurality of sets of electrode elements is also implanted within the person's body.Type: GrantFiled: September 12, 2022Date of Patent: March 21, 2023Assignee: Novocure GmbHInventors: Yoram Wasserman, Zeev Bomzon, Hadas Sara Hershkovich, Ariel Naveh, Moshe Giladi, Eilon Kirson, Golan Bar-Tal, Tali Voloshin-Sela
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Publication number: 20230001197Abstract: Tumor treating fields (TTFields) can be delivered by implanting a plurality of sets of implantable electrode elements within a person's body. Temperature sensors positioned to measure the temperature at the electrode elements are also implanted, along with a circuit that collects temperature measurements from the temperature sensors. In some embodiments, an AC voltage generator configured to apply an AC voltage across the plurality of sets of electrode elements is also implanted within the person's body.Type: ApplicationFiled: September 12, 2022Publication date: January 5, 2023Applicant: Novocure GmbHInventors: Yoram WASSERMAN, Zeev BOMZON, Hadas Sara HERSHKOVICH, Ariel NAVEH, Moshe GILADI, Eilon KIRSON, Golan BAR-TAL, Tali VOLOSHIN-SELA
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Publication number: 20220387784Abstract: Tumors in portions of a subject's body that have a longitudinal axis (e.g., the torso, head, and arm) can be treated with TTFields by affixing first and second sets of electrodes at respective positions that are longitudinally prior to and subsequent to a target region. An AC voltage with a frequency of 100-500 kHz is applied between these sets of electrodes. This imposes an AC electric field with field lines that run through the target region longitudinally. The field strength is at least 1 V/cm in at least a portion of the target region. In some embodiments, this approach is combined with the application of AC electric fields through the target region in a lateral direction (e.g., front to back and/or side to side) in order to apply AC electric fields with different orientations to the target region.Type: ApplicationFiled: August 11, 2022Publication date: December 8, 2022Applicant: Novocure GmbHInventors: Eilon KIRSON, Yoram WASSERMAN, Hadas Sara HERSHKOVICH, Zeev BOMZON
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Patent number: 11471676Abstract: Tumor treating fields (TTFields) can be delivered by implanting a plurality of sets of implantable electrode elements within a person's body. Temperature sensors positioned to measure the temperature at the electrode elements are also implanted, along with a circuit that collects temperature measurements from the temperature sensors. In some embodiments, an AC voltage generator configured to apply an AC voltage across the plurality of sets of electrode elements is also implanted within the person's body.Type: GrantFiled: February 26, 2020Date of Patent: October 18, 2022Assignee: Novocure GmbHInventors: Yoram Wasserman, Zeev Bomzon, Hadas Sara Hershkovich, Ariel Naveh, Moshe Giladi, Eilon Kirson, Golan Bar-Tal, Tali Voloshin-Sela
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Patent number: 11452863Abstract: Tumors in portions of a subject's body that have a longitudinal axis (e.g., the torso, head, and arm) can be treated with TTFields by affixing first and second sets of electrodes at respective positions that are longitudinally prior to and subsequent to a target region. An AC voltage with a frequency of 100-500 kHz is applied between these sets of electrodes. This imposes an AC electric field with field lines that run through the target region longitudinally. The field strength is at least 1 V/cm in at least a portion of the target region. In some embodiments, this approach is combined with the application of AC electric fields through the target region in a lateral direction (e.g., front to back and/or side to side) in order to apply AC electric fields with different orientations to the target region.Type: GrantFiled: September 4, 2019Date of Patent: September 27, 2022Assignee: Novocure GmbHInventors: Eilon Kirson, Yoram Wasserman, Hadas Sara Hershkovich, Zeev Bomzon
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Publication number: 20220265982Abstract: Certain substances (e.g., large molecules) that ordinarily cannot traverse the blood brain barrier can be introduced into the brain by applying an alternating electric field to the brain for a period of time, wherein the frequency of the alternating electric field is selected so that application of the alternating electric field increases permeability of the blood brain barrier. In some embodiments, the frequency of the alternating electric field is less than 190 kHz (e.g., 100 kHz). Once the permeability of the blood brain barrier has been increased, the substance is able to cross the blood brain barrier.Type: ApplicationFiled: May 11, 2022Publication date: August 25, 2022Applicant: Novocure GmbHInventors: Carsten HAGEMANN, Mario LOHR, Almuth F. KESSLER, Malgorzata BUREK, Carola FORSTER, Catherine BRAMI, Hadas Sara HERSHKOVICH, Tali VOLOSHIN-SELA
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Patent number: 11400269Abstract: Certain substances (e.g., large molecules) that ordinarily cannot traverse the blood brain barrier can be introduced into the brain by applying an alternating electric field to the brain for a period of time, wherein the frequency of the alternating electric field is selected so that application of the alternating electric field increases permeability of the blood brain barrier. In some embodiments, the frequency of the alternating electric field is less than 190 kHz (e.g., 100 kHz). Once the permeability of the blood brain barrier has been increased, the substance is able to cross the blood brain barrier.Type: GrantFiled: August 22, 2019Date of Patent: August 2, 2022Assignee: Novocure GmbHInventors: Carsten Hagemann, Mario Lohr, Almuth F. Kessler, Malgorzata Burek, Carola Forster, Catherine Brami, Hadas Sara Hershkovich, Tali Voloshin-Sela
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Patent number: 11351349Abstract: Certain substances (e.g., large molecules) that ordinarily cannot traverse the blood brain barrier can be introduced into the brain by applying an alternating electric field to the brain for a period of time, wherein the frequency of the alternating electric field is selected so that application of the alternating electric field increases permeability of the blood brain barrier. In some embodiments, the frequency of the alternating electric field is less than 190 kHz (e.g., 100 kHz). Once the permeability of the blood brain barrier has been increased, the substance is able to cross the blood brain barrier.Type: GrantFiled: August 22, 2019Date of Patent: June 7, 2022Assignee: Novocure GmbHInventors: Carsten Hagemann, Mario Lohr, Almuth F. Kessler, Malgorzata Burek, Carola Forster, Catherine Brami, Hadas Sara Hershkovich, Tali Voloshin-Sela
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Publication number: 20210330950Abstract: Many drugs and other molecules cannot ordinarily traverse the blood brain barrier (BBB). However, when alternating electric fields at certain optimum frequencies (e.g., 100 kHz) are applied to the brain, the BBB becomes permeable to those molecules. When the alternating electric fields are discontinued, the BBB eventually recovers to its original impermeable state. Subsequently, re-application of alternating electric fields at the optimum frequencies will re-open the BBB. Ordinarily, many frequencies (e.g., 200 kHz) of alternating electric fields are either ineffective or less effective at inducing permeability than the optimum frequencies. But once the BBB has been opened by applying alternating electric fields at the optimum frequencies, alternating electric fields at non-optimum frequencies can maintain the permeability of a previously-opened BBB.Type: ApplicationFiled: April 21, 2021Publication date: October 28, 2021Applicant: Novocure GmbHInventors: Carsten HAGEMANN, Mario LOHR, Almuth F. KESSLER, Malgorzata BUREK, Carola FORSTER, Catherine BRAMI, Hadas Sara HERSHKOVICH, Tali VOLOSHIN-SELA
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Patent number: 10967167Abstract: Certain substances (e.g., large molecules) that ordinarily cannot traverse the blood brain barrier can be introduced into the brain by applying an alternating electric field to the brain for a period of time, wherein the frequency of the alternating electric field is selected so that application of the alternating electric field increases permeability of the blood brain barrier. In some embodiments, the frequency of the alternating electric field is less than 190 kHz (e.g., 100 kHz). Once the permeability of the blood brain barrier has been increased, the substance is able to cross the blood brain barrier.Type: GrantFiled: April 30, 2020Date of Patent: April 6, 2021Inventors: Carsten Hagemann, Mario Lohr, Almuth F. Kessler, Malgorzata Burek, Carola Forster, Catherine Brami, Hadas Sara Hershkovich, Tali Voloshin-Sela
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Patent number: D934892Type: GrantFiled: May 3, 2019Date of Patent: November 2, 2021Assignee: Novocure GmbHInventors: Hadas Sara Hershkovich, Zeev Bomzon, Gil Zigelman, Shira Luk-Zilberman, Ori Kook, Oren Bakalo