Patents by Inventor Hadas Zur

Hadas Zur has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Attenuated virus mutated at sites of evolutionarily conserved RNA structure
    Patent number: 11795440
    Abstract: Attenuated viruses and methods of designing them are disclosed. In one embodiment, there is disclosed an attenuated form of a virulent virus comprising an RNA encoding a viral protein or a nucleic acid sequence transcribable to said RNA, wherein the folding energy or structure of the RNA is changed at positions of evolutionarily conserved RNA structures with respect to that of said RNA encoding said viral protein in the virulent virus so as to bring about attenuation of the virus.
    Type: Grant
    Filed: September 5, 2021
    Date of Patent: October 24, 2023
    Assignees: RAMOT AT TEL-AVIV UNIVERSITY LTD., YEDA RESEARCH AND DEVELOPMENT CO. LTD., SYNVACCINE LTD.
    Inventors: Tamir Tuller, Eli Goz, Shimshi Atar, Hadas Zur
  • METHOD AND SYSTEM FOR DESIGNING POLYNUCLEOTIDE SEQUENCES AND POLYNUCLEOTIDE SEQUENCES OBTAINED THEREBY
    Publication number: 20230230658
    Abstract: Methods of designing a polynucleotide sequence for expressing a polypeptide-of-interest in a cell are provided. Also provided are artificial transcript sequences generated according to the present teachings. Further provided are methods of estimating the adaptiveness of a transcript sequence encoding a polypeptide-of-interest to a gene expression machinery in a cell.
    Type: Application
    Filed: March 20, 2023
    Publication date: July 20, 2023
    Applicant: Ramot at Tel-Aviv University Ltd.
    Inventors: Tamir TULLER, Hadas ZUR
  • Method and system for designing polynucleotide sequences and polynucleotide sequences obtained thereby
    Patent number: 11610650
    Abstract: Methods of designing a polynucleotide sequence for expressing a polypeptide-of-interest in a cell are provided. Also provided are artificial transcript sequences generated according to the present teachings. Further provided are methods of estimating the adaptiveness of a transcript sequence encoding a polypeptide-of-interest to a gene expression machinery in a cell.
    Type: Grant
    Filed: May 28, 2015
    Date of Patent: March 21, 2023
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Tamir Tuller, Hadas Zur
  • METHODS FOR MODIFYING THE GROWTH RATE OF A CELL
    Publication number: 20220098598
    Abstract: Genetically modified cells with at least one codon substituted to a synonymous codon, and with modified replicative fitness as compared to the unmodified cell, wherein a slower translating synonymous codon increases replicative fitness and a faster translating codon decreased replicative fitness are provided. Further, vaccine composition comprising those cells as well as methods for modifying replicative fitness of a cell are provided.
    Type: Application
    Filed: December 16, 2021
    Publication date: March 31, 2022
    Inventors: Tamir TULLER, Hadas ZUR, Rachel COHEN-KUPIEC
  • METHODS FOR DETERMINING INCREASED RISK OF CANCER DEVELOPMENT AND TREATING THE SAME
    Publication number: 20220042010
    Abstract: The present invention is directed to a method for treating cancer in a subject determined as having the presence of a G600>A substitution, a C601>T substitution, or both, in the B cell lymphoma 2 (BCL2) gene of a cell.
    Type: Application
    Filed: August 10, 2021
    Publication date: February 10, 2022
    Inventors: Tamir TULLER, Ofek SCHNITZER, Hadas ZUR, Zohar ZAFRIR
  • Methods for modifying the growth rate of a cell
    Patent number: 11236344
    Abstract: Genetically modified cells with at least one codon substituted to a synonymous codon, and with modified replicative fitness as compared to the unmodified cell, wherein a slower translating synonymous codon increases replicative fitness and a faster translating codon decreased replicative fitness are provided. Further, vaccine composition comprising those cells as well as methods for modifying replicative fitness of a cell are provided.
    Type: Grant
    Filed: May 21, 2018
    Date of Patent: February 1, 2022
    Assignee: RAMOT AT TEL-AVIV UNIVERSITY LTD.
    Inventors: Tamir Tuller, Hadas Zur, Rachel Cohen-Kupiec
  • ATTENUATED VIRUS MUTATED AT SITES OF EVOLUTIONARILY CONSERVED RNA STRUCTURE
    Publication number: 20220010287
    Abstract: Attenuated viruses and methods of designing them are disclosed. In one embodiment, there is disclosed an attenuated form of a virulent virus comprising an RNA encoding a viral protein or a nucleic acid sequence transcribable to said RNA, wherein the folding energy or structure of the RNA is changed at positions of evolutionarily conserved RNA structures with respect to that of said RNA encoding said viral protein in the virulent virus so as to bring about attenuation of the virus.
    Type: Application
    Filed: September 5, 2021
    Publication date: January 13, 2022
    Applicants: RAMOT AT TEL-AVIV UNIVERSITY LTD., YEDA RESEARCH AND DEVELOPMENT CO. LTD., SYNVACCINE LTD.
    Inventors: Tamir TULLER, Eli GOZ, Shimshi ATAR, Hadas ZUR
  • Attenuated virus mutated at sites of evolutionarily conserved RNA structure
    Patent number: 11111481
    Abstract: Attenuated viruses and methods of designing them are disclosed. In one embodiment, there is disclosed an attenuated form of a virulent virus comprising an RNA encoding a viral protein or a nucleic acid sequence transcribable to said RNA, wherein the folding energy or structure of the RNA is changed at positions of evolutionarily conserved RNA structures with respect to that of said RNA encoding said viral protein in the virulent virus so as to bring about attenuation of the virus.
    Type: Grant
    Filed: September 29, 2016
    Date of Patent: September 7, 2021
    Assignees: RAMOT AT TEL-AVIV UNIVERSITY LTD., YEDA RESEARCH AND DEVELOPMENT CO. LTD., SYNVACCINE LTD.
    Inventors: Tamir Tuller, Eli Goz, Shimshi Atar, Hadas Zur
  • METHODS FOR MODIFYING THE GROWTH RATE OF A CELL
    Publication number: 20180334679
    Abstract: Genetically modified cells with at least one codon substituted to a synonymous codon, and with modified replicative fitness as compared to the unmodified cell, wherein a slower translating synonymous codon increases replicative fitness and a faster translating codon decreased replicative fitness are provided. Further, vaccine composition comprising those cells as well as methods for modifying replicative fitness of a cell are provided.
    Type: Application
    Filed: May 21, 2018
    Publication date: November 22, 2018
    Inventors: Tamir Tuller, Hadas Zur, Rachel Cohen-Kupiec
  • ATTENUATED VIRUS MUTATED AT SITES OF EVOLUTIONARILY CONSERVED RNA STRUCTURE
    Publication number: 20180273911
    Abstract: Attenuated viruses and methods of designing them are disclosed. In one embodiment, there is disclosed an attenuated form of a virulent virus comprising an RNA encoding a viral protein or a nucleic acid sequence transcribable to said RNA, wherein the folding energy or structure of the RNA is changed at positions of evolutionarily conserved RNA structures with respect to that of said RNA encoding said viral protein in the virulent virus so as to bring about attenuation of the virus.
    Type: Application
    Filed: September 29, 2016
    Publication date: September 27, 2018
    Inventors: Tamir TULLER, Eli GOZ, Shimshi ATAR, Hadas ZUR
  • METHOD AND SYSTEM FOR DESIGNING POLYNUCLEOTIDE SEQUENCES AND POLYNUCLEOTIDE SEQUENCES OBTAINED THEREBY
    Publication number: 20150347677
    Abstract: Methods of designing a polynucleotide sequence for expressing a polypeptide-of-interest in a cell are provided. Also provided are artificial transcript sequences generated according to the present teachings. Further provided are methods of estimating the adaptiveness of a transcript sequence encoding a polypeptide-of-interest to a gene expression machinery in a cell.
    Type: Application
    Filed: May 28, 2015
    Publication date: December 3, 2015
    Inventors: Tamir Tuller, Hadas Zur