Patents by Inventor Hadassah Sumum Sade

Hadassah Sumum Sade has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of treating cancer in a patient by administering an antibody which binds colony stimulating factor-1 receptor (CSF-1R)
    Patent number: 11542335
    Abstract: The current invention relates to the intermittent dosing of an anti-CSF-1R antibody in combination with macrophage activating agent, corresponding pharmaceutical compositions or medicaments using such combination therapy.
    Type: Grant
    Filed: February 25, 2019
    Date of Patent: January 3, 2023
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Sabine Hoves, Chia-Huey Ooi, Carola Ries, Solange Romagnoli, Dominik Ruettinger, Hadassah Sumum Sade
  • Distance-based tumor classification
    Patent number: 11017533
    Abstract: The system is configured to receive at least one digital image of a tissue sample of a patient; analyze the at least one received image for identifying tumor cells in a region of the at least one received image; analyze the at least one received image for identifying FAP+ areas in the region, each FAP+ area being a pixel blob representing one or more cells express the fibroblast activation protein—“FAP”; analyze the at least one received image for identifying distances between the identified tumor cells and their respective nearest FAP+ area; computing a proximity measure as a function of the identified distances; process the proximity measure by a classifier for generating a classification result, the classification result indicating if the tumor of the patient can be treated by a drug or drug-component that binds to FAP; and output the classification result.
    Type: Grant
    Filed: November 2, 2017
    Date of Patent: May 25, 2021
    Assignee: HOFFMANN-LA ROCHE INC.
    Inventors: Fabien Gaire, Oliver Grimm, Hadassah Sumum Sade, Suzana Vega Harring
  • Intermittent dosing of an anti-CSF-1R antibody in combination with macrophage activating agent
    Publication number: 20190284284
    Abstract: The current invention relates to the intermittent dosing of an anti-CSF-1R antibody in combination with macrophage activating agent, corresponding pharmaceutical compositions or medicaments using such combination therapy.
    Type: Application
    Filed: February 25, 2019
    Publication date: September 19, 2019
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Sabine HOVES, Chia-Huey OOI, Carola RIES, Solange ROMAGNOLI, Dominik RUETTINGER, Hadassah Sumum SADE
  • DISTANCE-BASED TUMOR CLASSIFICATION
    Publication number: 20190287249
    Abstract: The system is configured to receive at least one digital image of a tissue sample of a patient; analyze the at least one received image for identifying tumor cells in a region of the at least one received image; analyze the at least one received image for identifying FAP+ areas in the region, each FAP+ area being a pixel blob representing one or more cells express the fibroblast activation protein—“FAP”; analyze the at least one received image for identifying distances between the identified tumor cells and their respective nearest FAP+ area; computing a proximity measure as a function of the identified distances; process the proximity measure by a classifier for generating a classification result, the classification result indicating if the tumor of the patient can be treated by a drug or drug-component that binds to FAP; and output the classification result.
    Type: Application
    Filed: November 2, 2017
    Publication date: September 19, 2019
    Applicant: HOFFMANN-LA ROCHE INC.
    Inventors: Fabien GAIRE, Oliver GRIMM, Hadassah Sumum SADE, Suzana VEGA HARRING
  • METHOD AND CONSTRUCTS FOR THE pH DEPENDENT PASSAGE OF THE BLOOD-BRAIN-BARRIER
    Publication number: 20170174776
    Abstract: Herein is reported a fusion polypeptide comprising i) at least one binding site, e.g. which comprises an antibody heavy chain variable domain and an antibody light chain variable domain, and which binds to an internalizing cell surface receptor, and ii) at least one pharmaceutically active compound, whereby the EC50-value of the binding pair that binds to an internalizing cell surface receptor determined at pH 5.5 is higher than the EC50-value of the same binding pair determined at pH 7.4 and its use for delivering a pharmaceutically active compound across the blood-brain-barrier.
    Type: Application
    Filed: December 1, 2015
    Publication date: June 22, 2017
    Applicant: Roche Glycart AG
    Inventors: Bernd Bohrmann, Per-Ola Freskgard, Adrian Hugenmatter, Erhard Kopetzki, Ekkehard Moessner, Jens Niewoehner, Hadassah Sumum Sade, Pablo Umaña
  • Method and Constructs for the pH Dependent Passage of the Blood-brain-barrier
    Publication number: 20120282176
    Abstract: Herein is reported a fusion polypeptide comprising i) at least one binding site, e.g. which comprises an antibody heavy chain variable domain and an antibody light chain variable domain, and which binds to an internalizing cell surface receptor, and ii) at least one pharmaceutically active compound, whereby the EC50-value of the binding pair that binds to an internalizing cell surface receptor determined at pH 5.5 is higher than the EC50-value of the same binding pair determined at pH 7.4 and its use for delivering a pharmaceutically active compound across the blood-brain-barrier.
    Type: Application
    Filed: April 18, 2012
    Publication date: November 8, 2012
    Applicant: Roche Glycart AG
    Inventors: Bernd Bohrmann, Per-Ola Freskgard, Adrian Hugenmatter, Erhard Kopetzki, Ekkehard Moessner, Jens Niewoehner, Hadassah Sumum Sade, Pablo Umaña