Abstract: A system and method for interchanging footwear uppers provide a shoe body that is manually divisible between a sole portion and one or more interchangeable upper portions. One or more upper portion utilize a hook and loop fastening mechanism to detachably mate with a single sole portion. The system comprises a hook panel having multiple hooks, such as those found on Velcro™. The hook panel overlays a top face of the sole portion, with the hooks facing outwardly. The system also provides a loop panel comprising multiple small loops, from the same hook and loop fastener. The loop panel overlays a lasting panel from the upper portions. The hook panel and the loop panel detachably and temporarily mate to create a detachable mating relationship between the upper portions and a single sole portion. Consequently, multiple upper portions can be interchanged on a single, reusable sole portion.