Patents by Inventor Hafez Hafezzadeh

Hafez Hafezzadeh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20060167220
    Abstract: The formation of inactive, insoluble forms of peptide can be minimized or, alternatively, inactive, insoluble forms of peptide compounds, if present, can be converted into more physiologically active, soluble forms by dissolving peptide samples in aqueous base and then acidifying the aqueous mixture to precipitate the peptide in the presence of at least one of a salt and a co-solvent. Preferably, both a salt and co-solvent are present. By carrying out the precipitation relatively rapidly (at least in a first stage of acidifying in which the pH of the alkaline medium is reduced to a pH in the range of 6 to 7.5, after which acidification to a final desired pH, e.g., 3 to 6, can occur more slowly) at relatively low temperature, the dissolution characteristics of the resultant precipitated peptide are even further improved. The process is robust, consistent, and suitable for commercial scale manufacture of peptides.
    Type: Application
    Filed: December 28, 2005
    Publication date: July 27, 2006
    Inventors: Richard Dauer, Christina Evanson, Paul Friedrich, Hafez Hafezzadeh, Ramakrishna Nalitham, Stephen Schneider, Mark Schwindt, Roger Snyder, Joseph White, Gregory Withers
  • Patent number: 5470580
    Abstract: The present invention relates to directly-compressible naproxen or naproxen sodium compositions comprising spray-dried naproxen or naproxen sodium. The present invention further relates the processes for preparing the directly-compressible naproxen or naproxen sodium compositions, to aqueous mixtures containing naproxen or sodium naproxen suitable for spray-drying and useful in the processes for preparing the directly-compressible compositions, to naproxen or naproxen sodium tablets prepared from the directly-compressible compositions, and to the processes for preparing the naproxen or naproxen sodium tablets.
    Type: Grant
    Filed: July 6, 1994
    Date of Patent: November 28, 1995
    Assignee: Syntex Pharmaceuticals International Limited
    Inventors: Roy Kuramoto, Zakauddin T. Chowhan, Ranal O. Pendleton, Hafez Hafezzadeh
  • Patent number: 5358717
    Abstract: The present invention relates to directly-compressible naproxen or naproxen sodium compositions comprising spray-dried naproxen or naproxen sodium. The present invention further relates the processes for preparing the directly-compressible naproxen or naproxen sodium compositions, to aqueous mixtures containing naproxen or sodium naproxen suitable for spray-drying and useful in the processes for preparing the directly-compressible compositions, to naproxen or naproxen sodium tablets prepared from the directly-compressible compositions, and to the processes for preparing the naproxen or naproxen sodium tablets.
    Type: Grant
    Filed: May 4, 1992
    Date of Patent: October 25, 1994
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: Roy Kuramoto, Zakauddin T. Chowhan, Randal O. Pendleton, Hafez Hafezzadeh