Abstract: The present invention is directed to oligonucleotide conjugates, pharmaceutical compositions comprising same and to methods for use thereof, such as for the treatment and/or prevention of a genetic disease, or a viral disease in a subject.

Abstract: The Invention provides a novel delivery system for delivery of drugs across biological membranes. It provides novel chemical conjugates that comprise said delivery system, methods for synthesis of said compounds, and methods for utilization of said delivery system, among others, for delivery of genetic drugs into tissues and cells, in vitro, ex vivo, and in vivo, for the treatment of various medical disorders.

Abstract: Compositions containing a polyphosphate and an amino acid N,N-diacetic acid, formulated as either liquid compositions that upon warming to body temperature solidify into a viscous gel, or solid dosage forms, which are useful as dental compositions for removing microbial biofilm, or inhibiting or disrupting formation thereof. A method for removing microbial biofilm from, or inhibiting or disrupting microbial biofilm formation in, a periodontal pocket, gingival pocket, pocket resulting from peri-implantitis, or caries associated with dental cavities or the root canal system, including administering the compositions.

Abstract: A first request to access a messaging conversation management service that permits the first user account to view and transfer text message conversations between other user accounts of multiple user accounts and multiple recipient devices is received by a communication services platform via a first application programming interface (API) call from a first client device associated with a first user account. Responsive to receiving the first request, whether the first user account is authorized to access the messaging conversation management service is determined. Responsive to determining that the first user account is authorized to access the messaging conversation management service, a first indication of the text message conversations between the other user accounts of the multiple user accounts and the multiple recipient devices is sent to the first client device for display at the first client device.

Abstract: Apparatus and methods are described including a ventricular assist device that includes a frame having struts that define a plurality of cells. In its non-radially-constrained configuration, the frame includes a generally cylindrical portion. A tube defines blood outlet openings, and a portion of the tube is disposed outside the frame and is coupled to the generally cylindrical portion of the frame, such that the portion of the tube conforms with a structure of struts of the frame. An inner lining is coupled to an inside of the generally cylindrical portion of the frame, such as to provide the generally cylindrical portion of the frame with a smooth inner surface. An impeller is disposed at least partially inside the generally cylindrical portion of the frame and is configured to pump blood through the tube and out of the one of more blood outlet openings. Other applications are also described.

Abstract: A defoamer or anti-foam formulation and a process for preparing the same. The process includes in a first step, preparing branched organopolysiloxanes (A) by irradiating organopolysiloxanes (X) of the formula (1) R13-a(R2O)aSi—[OSiR32]n—OSi(OR2)aR13-a ??(1). Where with high-energy radiation, the viscosity of the organopolysiloxanes (A) is at least 40% higher than the viscosity of the organopolysiloxanes (X). In a second step, the branched organopolysiloxanes (A) are treated with a filler (B) which is selected from precipitated and/or fumed silicas, and organopolysiloxane resins (C).

Abstract: The present invention relates to novel di-imine, oxadiazepine and oxadiazine intermediates as key intermediates for preparation of oxadiazine insecticides, the processes of their preparation, purification and use in the preparation of final oxadiazine pesticides, in particular of indoxacarb. Telescopic process of preparation of arthropocidal oxadiazines, in particular indoxacarb is disclosed.

Abstract: The present disclosure relates to solid state forms of Indoxacarb or its solvate, processes for preparation thereof and agrochemical compositions thereof.

Abstract: Apparatus and methods are described including a left-ventricular assist device configured to assist left-ventricular functioning of a subject. The left-ventricular assist device includes a frame, a rigid axial shaft extending from a proximal end of the frame to a distal end of the frame, and an impeller disposed on the rigid axial shaft. A motor is disposed outside the subject's body, and a flexible drive cable extends from outside the subject's body to the axial shaft. The drive cable imparts rotational motion from the motor to the rigid axial shaft, to thereby rotate the impeller. Other applications are also described.

Abstract: The present invention is directed to, inter alia, therapeutic compositions comprising therapeutically effective amount of exosomes derived from cells having increased glucose transporter type 4 (GLUT4) activity, and a pharmaceutically acceptable. The invention is further directed to methods for reducing glucose levels in a subject in need thereof.

Abstract: Apparatus and methods are described including a left-ventricular assist device that includes a self-expandable impeller and a pump-outlet tube. The impeller is configured to be deployed in a left ventricle of a subject and to pump blood from the subject's left ventricle to an aorta of the subject via the pump-outlet tube, for a period of more than two days. The impeller is configured to provide blood flow of more than 4.5 L/min, when pumping against a pressure gradient of 50 mmHg. Other applications are also described.

Abstract: Apparatus and methods are described including a left-ventricular assist device. A pump pumps blood from the subject's left ventricle to the subject's aorta, via a tube. A distal-tip element is disposed distally to the pump and defines a straight proximal portion that defines a longitudinal axis, and a curved distal portion that is shaped such as to curve in a first direction with respect to the longitudinal axis of the straight proximal portion before passing through an inflection point and curving in a second direction with respect to the longitudinal axis of the straight proximal portion, such that the curved distal portion defines a bulge on one side of the longitudinal axis of the straight proximal portion. Other applications are also described.

Abstract: Apparatus and methods are described including a blood pump configured to be placed inside a subject's body. The blood pump includes an impeller, a frame disposed around the impeller, a distal-tip portion disposed distally with respect to the frame, and a valve disposed within the distal-tip portion. Other applications are also described.

Abstract: A first request to identify, among a plurality of user accounts, a subset of user accounts that are available to receive a transfer of a messaging conversation with a recipient device is received via a first application programming interface (API) call from a first client device associated with a first user account. A first response identifying the subset of user accounts that are available to receive the transfer of the messaging conversation is sent to the first client device responsive to receiving the first request. A second request to transfer the messaging conversation to a second user account identified among the subset of user accounts is received via a second API call from the first client device. The messaging conversation is transferred to the second user account to facilitate a continuation of the messaging conversation with the recipient device responsive to receiving the second request.

Abstract: Disclosed herein is a system for determining scores that are usable to filter a larger set of metrics (e.g., thousands of metrics) down to a smaller set of relevant metrics (e.g., hundreds of metrics) that can be more efficiently queried and ingested for root-cause analysis of an incident. During a training stage, the system analyzes known incidents and converts the names of the metrics, as described via customer-defined words, into mathematical representations (e.g., word embedding featurization vectors). When a new metric with a new name is received for a new incident, the system implements an incident inference stage during which the new name is converted into a new mathematical representation. The system compares the new mathematical representation to the mathematical representations to identify a similar mathematical representation. The system retrieves the score for the metric associated with the similar mathematical representation and assigns the retrieved score to the new metric.

Abstract: Apparatus and methods are described including a blood pump that includes an impeller configured to pump blood through a subject's body, and a frame disposed around the impeller. In a radially-non-constrained configuration of the frame, the frame defines a proximal conical portion and a cylindrical portion disposed distally to the proximal conical portion. The blood pump is configured such that such that, during at least some of the operation of the blood pump, at least a portion of the impeller is disposed within the proximal conical portion of the frame. Other applications are also described.

Abstract: The disclosure relates to utilizing an anomaly mitigation proposal system to determine root causes, summarize anomalous metrics, and report mitigation actions for service incidents in cloud computing systems. Based on receiving an incident report request, the anomaly mitigation proposal system utilizes a two-layer approach that implements large generative language models to generate incident reports that include clear and concise text narratives summarizing metric anomalies, root causes, and corresponding mitigation actions. For example, the anomaly mitigation proposal system initially utilizes an online generative language model to provide these incident reports and, when unavailable within a time threshold, a fallback model that references root cause datastores.

Abstract: A method, computer program product, and computing system for processing event data associated with a plurality of known operational impact events on a business service and operational data associated with the business service using a supervised machine learning model conditioned on an operational impact parameter associated with the business service. A detection threshold is generated using the supervised machine learning model.

Abstract: Apparatus and methods are described including a left-ventricular assist device that includes a frame that includes proximal and distal frame portions that include struts that define cells, and a central frame portion that includes helical struts. An impeller is disposed inside the frame, the impeller being configured to rotate such as to pump blood from a left ventricle of a subject to an aorta of the subject. Other applications are also described.

Abstract: Techniques for registering carbon sequestration include: receiving carbon sequestration data corresponding portions of a geographic region; comparing entries to a registry; assigning entries to clusters associated with carbon sequestration values; and determining a total carbon sequestration based on an aggregating of carbon sequestration values of the entries. In another aspect, a register-based carbon sequestration may utilize continuous learning, including generating estimates of carbon sequestration based on high-resolution aerial LiDAR, multispectral imagery, or the like. Unsupervised learning and a ground-based calibration procedure are usable to delineate distinct forest types within mixed forest area. Such a calibrated carbon sequestration system demonstrates superior accuracy compared to satellite-based analysis, and is able to estimate carbon sequestration on a grid, enabling generalization across multiple forest types and scales of aggregation within a unified framework.