Patents by Inventor Hagit Grimberg

Hagit Grimberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds and methods for trans-membrane delivery of molecules
    Patent number: 11230710
    Abstract: A system for delivery of drugs, and especially genetic drugs such as siRNA or antisense oligonucleotides (ASO) across biological membranes is provided. It comprises a trans-membrane delivery moiety, energized by the membrane internal electrical field, and a redox-sensitive disulfide moiety, designed to be reduced at the cytoplasm, thus releasing the cargo drug to exert its pharmaceutical effects at its target sites.
    Type: Grant
    Filed: January 9, 2018
    Date of Patent: January 25, 2022
    Assignee: Aposense Ltd
    Inventors: Ilan Ziv, Joseph Dubrovsky, Hagit Grimberg
  • COMPOUNDS AND METHODS FOR TRANS-MEMBRANE DELIVERY OF MOLECULES
    Publication number: 20210052736
    Abstract: The Invention provides a novel delivery system for delivery of drugs across biological membranes. It provides novel chemical conjugates that comprise said delivery system, methods for synthesis of said compounds, and methods for utilization of said delivery system, among others, for delivery of genetic drugs into tissues and cells, in vitro, ex vivo, and in vivo, for the treatment of various medical disorders.
    Type: Application
    Filed: December 31, 2018
    Publication date: February 25, 2021
    Applicant: APOSENSE LTD
    Inventors: llan ZIV, Hagit GRIMBERG, JOSEPH DUBROVSKY
  • COMPOUNDS AND METHODS FOR TRANS-MEMBRANE DELIVERY OF MOLECULES
    Publication number: 20200392490
    Abstract: A system for delivery of drugs, and especially genetic drugs such as siRNA or antisense oligonucleotides (ASO) across biological membranes is provided. It comprises a trans-membrane delivery moiety, energized by the membrane internal electrical field, and a redox-sensitive disulfide moiety, designed to be reduced at the cytoplasm, thus releasing the cargo drug to exert its pharmaceutical effects at its target sites.
    Type: Application
    Filed: January 9, 2018
    Publication date: December 17, 2020
    Applicant: Aposense LTD.
    Inventors: Ilan ZIV, Joseph DUBROVSKY, Hagit GRIMBERG
  • COMPOUNDS AND METHODS FOR TRANS-MEMBRANE DELIVERY OF MOLECULES
    Publication number: 20190125884
    Abstract: A conjugate for delivery of drugs, such as genetic drugs, (e.g., siRNA or antisense oligonucleotides (ASO) across biological membranes is provided. The conjugates of the Invention are capable of delivering drugs in both presence and absence of plasma proteins.
    Type: Application
    Filed: July 4, 2017
    Publication date: May 2, 2019
    Inventors: Ilan ZIV, Joseph Dubrovsky, Hagit Grimberg
  • Compounds and methods for trans-membrane delivery of molecules
    Patent number: 10195286
    Abstract: A conjugate for delivery of drugs, such as genetic drugs, [e.g., siRNA, dsiRNA, or antisense oligonucleotides (ASO)] across biological membranes is provided. The conjugates of the Invention are capable of delivering drugs in both presence and absence of plasma proteins.
    Type: Grant
    Filed: August 31, 2017
    Date of Patent: February 5, 2019
    Assignee: Aposense Ltd.
    Inventors: Ilan Ziv, Hagit Grimberg, Joseph Dubrovsky
  • COMPOUNDS AND METHODS FOR TRANS-MEMBRANE DELIVERY OF MOLECULES
    Publication number: 20190008976
    Abstract: A conjugate for delivery of drugs, such as genetic drugs, [e.g., siRNA, dsiRNA, or antisense oligonucleotides (ASO)]across biological membranes is provided. The conjugates of the Invention are capable of delivering drugs in both presence and absence of plasma proteins.
    Type: Application
    Filed: August 31, 2017
    Publication date: January 10, 2019
    Applicant: Aposense LTD.
    Inventors: Ilan ZIV, Hagit GRIMBERG, Joseph DUBROVSKY
  • Pharmaceutical compounds
    Patent number: 9192680
    Abstract: Novel compounds and pharmaceutical compositions are provided. In one aspect of the invention the compounds may be utilized in medical practice for treating pancreatic cancer.
    Type: Grant
    Filed: November 13, 2014
    Date of Patent: November 24, 2015
    Assignee: Aposense LTD.
    Inventors: Ilan Ziv, Hagit Grimberg
  • NOVEL PHARMACEUTICAL COMPOUNDS
    Publication number: 20150072949
    Abstract: Novel compounds and pharmaceutical compositions are provided. In one aspect of the invention the compounds may be utilized in medical practice for treating pancreatic cancer.
    Type: Application
    Filed: November 13, 2014
    Publication date: March 12, 2015
    Inventors: Ilan ZIV, Hagit GRIMBERG
  • Pharmaceutical compounds
    Patent number: 8916537
    Abstract: Novel compounds and pharmaceutical compositions are provided. In one aspect of the invention the compounds may be utilized in medical practice, for example, in treatment of cancer and immune disorders.
    Type: Grant
    Filed: August 8, 2013
    Date of Patent: December 23, 2014
    Assignee: Aposense Ltd.
    Inventors: Ilan Ziv, Hagit Grimberg
  • NOVEL PHARMACEUTICAL COMPOUNDS
    Publication number: 20130324494
    Abstract: Novel compounds and pharmaceutical compositions are provided. In one aspect of the invention the compounds may be utilized in medical practice, for example, in treatment of cancer and immune disorders.
    Type: Application
    Filed: August 8, 2013
    Publication date: December 5, 2013
    Applicant: Aposense Ltd.
    Inventors: Ilan ZIV, Hagit Grimberg
  • Pharmaceutical compounds
    Patent number: 8530444
    Abstract: Novel compounds and pharmaceutical compositions are provided. In one aspect of the invention the compounds may be utilized in medical practice, for example, in treatment of cancer and immune disorders.
    Type: Grant
    Filed: June 1, 2010
    Date of Patent: September 10, 2013
    Assignee: Aposense Ltd.
    Inventors: Ilan Ziv, Hagit Grimberg
  • CONJUGATES OF CYTOTOXIC DRUGS
    Publication number: 20120142722
    Abstract: Novel compounds and pharmaceutical compositions are provided. In one aspect of the invention the compounds may be utilized in medical practice, for example, in treatment of cancer and immune disorders. In another aspect of the invention there is provided a conjugate, comprising a cytotoxic agent and a modulating moiety, the modulating moiety serving to target apoptotic cells.
    Type: Application
    Filed: June 23, 2010
    Publication date: June 7, 2012
    Inventors: Ilan Ziv, Anat Shirvan, Hagit Grimberg
  • NOVEL PHARMACEUTICAL COMPOUNDS
    Publication number: 20110294754
    Abstract: Novel compounds and pharmaceutical compositions are provided. In one aspect of the invention the compounds may be utilized in medical practice, for example, in treatment of cancer and immune disorders.
    Type: Application
    Filed: June 1, 2010
    Publication date: December 1, 2011
    Inventors: Ilan ZIV, Hagit Grimberg