Abstract: A gemfibrozil salt and composition thereof comprising a gemfibrozil salt having a solubility greater than at least that of free-form gemfibrozil in artificial saliva. A method of making a gemfibrozil salt by combining a free form of gemfibrozil with a pharmacologically acceptable salt former. A pharmaceutical composition and a method of treating a patient in need thereof with a gemfibrozil salt.

Abstract: The present invention provides isolated nucleic acid sequences encoding presenilin stabilization factor (PSF) and PSF-like (PSFL) protein, vectors comprising same, host cells transformed with the vectors, and transgenic animals containing the host cells. The present invention further provides purified PSF and PSFL polypeptides, methods for making same, and pharmaceutical compositions comprising the polypeptides. Also provided are agents reactive with the nucleic acid sequences and polypeptides, kits comprising same, and methods for producing same. The present invention further provides methods for decreasing amyloid-beta (A?) production, destabilizing presenilin or nicastrin, destabilizing a gamma-secretase complex, and inhibiting activity of gamma-secretase, and pharmaceutical compositions for accomplishing same. The present invention further provides methods for treating neurodegeneration in a subject.